Results 181 to 190 of about 243,525 (310)

Association of MHC class II β domain polymorphism in channel catfish (Ictalurus punctatus) with natural infection by Ligictaluridus floridanus. [PDF]

Parasitol Res
Roldán GMG, Bracamonte GMP, González FB, Alfaro IOM, Di Carlo Quiroz Velásquez J, De La Rosa-Reyna XF.   +5 more
europepmc   +1 more source

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

Advanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang, Ning Lu, Xin‐Xiu Lin, Xu‐Hui Fang, Yi‐Hui Li, Qing‐Peng Luo, Yu‐Ting Peng, Gil Mor, Ai‐Hua Liao   +8 more
wiley   +1 more source

Case Report: A novel CIITA mutation causing MHC class II deficiency: first reported case in Morocco. [PDF]

Front Immunol
Kattra AB, Ailal F, Benhsaien I, Fahi M, Drissi Bourhanbour A, Elamine A, Aadam Z, Errami A, Bousfiha AA, El Bakkouri J.   +9 more
europepmc   +1 more source

The MHC Class II Antigen-Processing and Presentation Pathway Is Dysregulated in Type 1 Diabetes. [PDF]

J Immunol, 2023
Gilles A, Hu L, Virdis F, Sant'Angelo DB, Dimitrova N, Hedrick JA, Denzin LK.   +6 more
europepmc   +1 more source

Liver Kinase B1 in CD11c+ Cells Inhibits Fibrosis in Chronic Pancreatitis via the Oncostatin M Signaling

Advanced Science, EarlyView.
This study demonstrates significantly reduced Lkb1 expression in CD11c+ cells in chronic pancreatitis (CP) patients and animal models. Lkb1 deletion enhances CD11c+CD206+ macrophage infiltration and reprograms pancreatic stellate cells (PSCs) via OSM signaling.
Wenqing Zhang, Shan Guo, Yu Zhang, He Ren, Ke Lei, Chenyang Zhao, Qian Yu, Hongqing Luo, Yujing Xiao, Xiaoming Feng, Xiaoyu Li   +10 more
wiley   +1 more source

A superantigen-based MHC class II-targeted cancer immunotherapy for the treatment of acute myeloid leukemia. [PDF]

Blood Cancer J
Golick L, Robinson RM, Reyes L, St Thomas N, Klinzing K, O'Connor EC, Ferreira LMR, Dolloff NG.   +7 more
europepmc   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Exploring MHC class II I-Ab blockade as a potential treatment for Sjögren's disease in the mouse model. [PDF]

Immunohorizons
Voigt A, Gupta S, Shen Y, Glenton P, Li D, Ostrov D, Bhattacharyya I, Nguyen CQ.   +7 more
europepmc   +1 more source

Regulation of MHC Class II Gene Expression

Immunobiology, 1995
Reith, Walter, Steimle, Viktor, Durand, Bénédicte, Kobr, M., Mach, Bernard   +4 more
openaire   +3 more sources

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source