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Proximity-Based Labeling Identifies MHC Class II and CD37 as B Cell Receptor-Proximal Proteins with Immunological Functions. [PDF]
ImmunohorizonsHoeger S, Drake LA, Drake JR.
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Nonclassical MHC Class II Molecules
Annual Review of Immunology, 2000Major histocompatibility complex (MHC) class II molecules are cell surface proteins that present peptides to CD4+T cells. In addition to these wellcharacterized molecules, two other class II–like proteins are produced from the class II region of the MHC, HLA-DM (DM) and HLA-DO (DO) (called H2-M, or H2-DM and H2-O in the mouse).
C, Alfonso, L, Karlsson
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MHC class I and II deficiencies
Journal of Allergy and Clinical Immunology, 2014Deficiencies of MHC complex class I or II are rare primary immunodeficiencies, both of which are inherited in an autosomal recessive pattern. MHC class II deficiency is a prototype of a disease of gene regulation. Defects in transacting regulatory factors required for expression of MHC class II genes, rather than the genes themselves, are responsible ...
Suheir Hanna, Amos Etzioni
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Mice lacking MHC class II molecules
Cell, 1991We have produced mice that lack major histocompatibility complex class II antigens, permitting us to evaluate the role of these molecules in diverse aspects of T and B cell differentiation. The mutant mice show near-complete elimination of CD4+ T lymphocytes from the spleen and lymph nodes; the few remaining CD4-positive cells are preferentially ...
D, Cosgrove +6 more
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Mutations of class II MHC molecules
Immunology Today, 1987It remains unclear how the tertiary interaction of T-cell receptor, la molecule and foreign antigen results in the extensive diversity of the helper T cell repertoire. Here Laurie Glimcher and Irwin Griffith focus on what has been learned about the relationship between structure and function of the la molecule from the use of mouse strains with ...
L H, Glimcher, I J, Griffith
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MHC Class-II Molecules and Autoimmunity
Annual Review of Immunology, 1991Molecular and genetic studies of HLA class-II genes provide new insights into the basis for MHC associations with autoimmunity. Polymorphisms among class-II genes identify specific haplotypes associated with autoimmune diseases such as type-I diabetes, rheumatoid arthritis, celiac disease, and pemphigus vulgaris.
G T, Nepom, H, Erlich
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Regulation of Class II MHC Expression
Critical Reviews™ in Immunology, 1996The class II genes of the major histocompatibility complex (MHC) encode the alpha/beta heterodimeric glycoproteins that play a critical role in the induction of immune responses through presentation of processed antigen to CD4+ T lymphocytes. The constitutive expression of class II MHC antigens is restricted primarily to B cells, dendritic cells ...
W M, Rohn, Y J, Lee, E N, Benveniste
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Mutation of RFXAP, a Regulator of MHC Class II Genes, in Primary MHC Class II Deficiency
New England Journal of Medicine, 1997Major-histocompatibility-complex (MHC) class II deficiency is an autosomal recessive primary immunodeficiency disease in which MHC class II molecules are absent. It is a genetically heterogeneous disease of gene regulation resulting from defects in several transactivating genes that regulate the expression of MHC class II genes.
Villard, Jean +5 more
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MHC class II restricted antigen presentation
Current Opinion in Immunology, 1997Presentation of antigenic peptides by MHC class II molecules to CD4(+) T cells requires many events in both the biosynthetic and endocytic pathways that must all occur in a controlled and coordinated fashion. In recent years the roles of two important chaperones, the invariant chain and the HLA-DM dimer, in promoting the acquisition of peptides by MHC ...
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