Results 221 to 230 of about 255,748 (249)
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MHC Class-II Molecules and Autoimmunity
Annual Review of Immunology, 1991Molecular and genetic studies of HLA class-II genes provide new insights into the basis for MHC associations with autoimmunity. Polymorphisms among class-II genes identify specific haplotypes associated with autoimmune diseases such as type-I diabetes, rheumatoid arthritis, celiac disease, and pemphigus vulgaris.
G T, Nepom, H, Erlich
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Regulation of Class II MHC Expression
Critical Reviews™ in Immunology, 1996The class II genes of the major histocompatibility complex (MHC) encode the alpha/beta heterodimeric glycoproteins that play a critical role in the induction of immune responses through presentation of processed antigen to CD4+ T lymphocytes. The constitutive expression of class II MHC antigens is restricted primarily to B cells, dendritic cells ...
W M, Rohn, Y J, Lee, E N, Benveniste
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Mutation of RFXAP, a Regulator of MHC Class II Genes, in Primary MHC Class II Deficiency
New England Journal of Medicine, 1997Major-histocompatibility-complex (MHC) class II deficiency is an autosomal recessive primary immunodeficiency disease in which MHC class II molecules are absent. It is a genetically heterogeneous disease of gene regulation resulting from defects in several transactivating genes that regulate the expression of MHC class II genes.
Villard, Jean +5 more
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MHC class II restricted antigen presentation
Current Opinion in Immunology, 1997Presentation of antigenic peptides by MHC class II molecules to CD4(+) T cells requires many events in both the biosynthetic and endocytic pathways that must all occur in a controlled and coordinated fashion. In recent years the roles of two important chaperones, the invariant chain and the HLA-DM dimer, in promoting the acquisition of peptides by MHC ...
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Identification of MHC Class II Binding Peptides: Microarray and Soluble MHC Class II Molecules
2009CD4+ T-helper cells recognize antigenic peptides presented by MHC class II molecules. The binding of the nominal peptide to the MHC class II allele is dependent on the amino acid sequence of the peptide as well as on amino acid (aa) residues in the peptide binding groove of the MHC class II allele.
Simani, Gaseitsiwe, Markus J, Maeurer
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Class II MHC typing in pemphigoid gestationis
Clinical and Experimental Dermatology, 1995Pemphigoid gestationis (PG) is a rare, autoimmune skin disease associated with pregnancy or the immediate post-partum period, previously shown to be associated with the HLA class II antigens DR3 and DR4. Advances in molecular analytical techniques now allow the identification of HLA alleles previously difficult to define by serological assays ...
J K, Shornick +7 more
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Antigen presentation by MHC class II molecules
Immunology & Cell Biology, 1997The tremendous explosion in the field of MHC research in the last 5 years has significantly advanced our understanding of antigen processing pathways, particularly with regard to details of MHC class II‐mediated antigen presentation. MHC class II molecules at the surface of antigen presenting cells present antigenie peptides to CD4+ T helper cells ...
S M, Weenink, A M, Gautam
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MHC class II expression in lung cancer
Lung Cancer, 2017Immunotherapy is an exciting development in lung cancer research. In this study we described major histocompatibility complex (MHC) Class II protein expression in lung cancer cell lines and patient tissues.We studied MHC Class II (DP, DQ, DR) (CR3/43, Abcam) protein expression in 55 non-small cell lung cancer (NSCLC) cell lines, 42 small cell lung ...
Yayi, He +7 more
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Transcriptional regulation of MHC class II genes
International Journal of Clinical & Laboratory Research, 1995MHC class II molecules play a fundamental role in the homeostasis of the immune response, functioning as receptors for antigenic peptides to be presented to regulatory T cells. Both quantitative and qualitative alterations in the expression of these molecules on the cell surface dramatically affect the onset of the immune response, and may be the basis
SARTORIS, Silvia, R. S. Accolla
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