Results 81 to 90 of about 534,915 (376)

Cohesin Regulates MHC Class II Genes through Interactions with MHC Class II Insulators [PDF]

The Journal of Immunology, 2011
Abstract Cohesin is a multiprotein, ringed complex that is most well-known for its role in stabilizing the association of sister chromatids between S phase and M. More recently, cohesin was found to be associated with transcriptional insulators, elements that are associated with the organization of chromatin into regulatory domains.
Parimal, Majumder, Jeremy M, Boss
openaire   +2 more sources

What Is the Role of Giant Endosomal Sorting Complexes Required for Transport (ESCRT) Structures in T Cell Activation?

Advanced Biology, EarlyView.
The article explores the discovery of unusually large, ring‐shaped ESCRT protein structures formed by immune and stromal cells. It investigates their formation, composition, and potential roles in immune synapse formation. The findings challenge assumptions about their function in immunological synapses, suggesting an exclusive role in maintaining ...
Anthi Psoma, Femmy C. Stempels, Rinse de Boer, Geert van den Bogaart   +3 more
wiley   +1 more source

Association between HLA-Class I and HLA-Class II Alleles and Mycobacterium Tuberculosis Infection in Iraqi Patients from Baghdad City

Iranian Journal of Medical Sciences, 2014
Background: Pulmonary tuberculosis (PT) is one of the endemic diseases in Iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (HLA) system.
Nidhal Abdulmohaimen Mohammed, Haitham Qassem, Farouk Hassen   +2 more
doaj  

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex [PDF]

, 2015
Central to adaptive immunity is the interaction between the αβ T cell receptor (TCR) and peptide presented by the major histocompatibility complex (MHC) molecule.
Beringer, Dennis X., Chen, Zhenjun, Dudek, Nadine L., Duinkerken, Gaby, Godfrey, Dale I., Joosten, Antoinette, Kleijwegt, Fleur S., Laban, Sandra, Loh, Khai Lee, McCluskey, James, Nikolic, Tatjana, Petersen, Jan, Price, David A., Purcell, Anthony W., Radford, Kristen J., Reid, Hugh H., Roep, Bart O., Rossjohn, Jamie, Tiganis, Tony, Uldrich, Adam P., van der Slik, Arno R., Vivian, Julian P., Wiede, Florian   +22 more
core   +1 more source

Aberrant Expression of MHC Class II in Melanoma Attracts Inflammatory Tumor-Specific CD4+ T- Cells, Which Dampen CD8+ T-cell Antitumor Reactivity.

Cancer Research, 2015
In the absence of a local inflammatory response, expression of MHC class II molecules is restricted mainly to hematopoietic cells and thymus epithelium. However, certain tumors, such as melanoma, may acquire aberrant constitutive expression of MHC class ...
M. Donia, R. Andersen, J. Kjeldsen, P. Fagone, Shamaila Munir, F. Nicoletti, M. Andersen, P. thor Straten, I. Svane   +8 more
semanticscholar   +1 more source

FOXP3 Polymorphism and Upregulation of the CXCL12‐CXCR4‐SNAIL Axis with High Infiltration of M2TAM by STAT3/NFKB Pathways Influence the Survival of Cervical Cancer Patients

Advanced Biology, EarlyView.
This study highlights how cervical carcinoma progression is shaped by immune–tumor interactions within the TME. M2‐TAM infiltration, regulated through STAT3/NF‐κB and linked to CXCL12–CXCR4, promotes immune suppression, angiogenesis, and poor survival.
George A. Lira, Fábio M. de Azevedo, Ingrid G. S. Lins, Janaína C. O. Crispim, Giovanna A. Lira, Rômulo S. Cavalcante, Ricardo Cobucci, Carolina O. Mendes‐Aguiar, Rafaela Torres Dantas Da Silva, Vinícius E. da Silva, Ryan C. Q. Aquino, Raimundo F. Araújo Júnior   +11 more
wiley   +1 more source

Comparative genome analyses reveal distinct structure in the saltwater crocodile MHC.

PLoS ONE, 2014
The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation.
Weerachai Jaratlerdsiri, Janine Deakin, Ricardo M Godinez, Xueyan Shan, Daniel G Peterson, Sylvain Marthey, Eric Lyons, Fiona M McCarthy, Sally R Isberg, Damien P Higgins, Amanda Y Chong, John St John, Travis C Glenn, David A Ray, Jaime Gongora   +14 more
doaj   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Trypanosoma brucei brucei infection impairs MHC class II antigen presentation capacity of macrophages

, 2000
During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite-related and unrelated antigens. In this study, the ability of macrophages from Trypanosoma b. brucei-infected mice to present exogenous antigens to a
Beschin, A, Brys, L, De Baetselier, P, Magez, Stefan, Namangala, B   +4 more
core   +2 more sources

Equine bone marrow-derived mesenchymal stromal cells are heterogeneous in MHC class II expression and capable of inciting an immune response in vitro

Stem cell research & therapeutics, 2014
The horse is a valuable species to assess the effect of allogeneic mesenchymal stromal cells (MSCs) in regenerative treatments. No studies to date have examined recipient response to major histocompatibility complex (MHC)-mismatched equine MSCs.
L. Schnabel, Lynn M Pezzanite, D. Antczak, M. Julia, B. Felippe, L. Fortier   +5 more
semanticscholar   +1 more source