Results 151 to 160 of about 225,250 (196)

PCBs and PBBs: Biologic and toxic effects on C57BL/6J and DBA/2J inbred mice

Toxicology, 1984
Treatment of genetically inbred "responsive" C57BL/6J and "non-responsive" DBA/2J mice with Aroclor 1254 or fireMaster BP-6 resulted in the induction of hepatic microsomal benzo[a]pyrene hydroxylase only in the former mouse strain and aminopyrine N-demethylase in both strains of mice.
L W, Robertson, A, Parkinson, S, Bandiera, I, Lambert, J, Merrill, S H, Safe   +5 more
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Genotypic differences in mesolimbic enkephalin gene expression in DBA/2J and C57BL/6J inbred mice

European Journal of Pharmacology, 1996
The DBA/2J and C57BL/6J (herein referred to as DBA and C57) inbred mouse strains exhibit low and high predispositions for voluntary ethanol consumption, respectively, but the neurobiological basis underlying this differential drug vulnerability remains poorly understood. Comparison of endogenous brain proenkephalin gene expression showed the C57 mouse,
G Y, Ng, B F, O'Dowd, S R, George
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Neuroanatomical divergence between two substrains of C57BL/6J inbred mice entails differential radial-maze learning

Brain Research, 1994
Compared to the parental strain C57BL/6J, male mice from the mutated substrain C57BL/6JNmg show smaller hippocampal intra- and infrapyramidal mossy fiber projections and a correlated inability to master a simple spatial radial-maze task. Possibly, these two substrains differ for only one single gene, making them a valuable model to investigate the ...
L, Jamot, J Y, Bertholet, W E, Crusio
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Identification of vacuolar autophagic aggregates in the skeletal muscles of inbred C57BL/6NCrl mice

Laboratory Animals, 2023
A comprehensive pathological analysis of inbred strains is essential to define strain-specific spontaneous lesions and to understand whether a specific phenotype results from experimental intervention or reflects a naturally occurring disease. This study aimed to report and describe a novel condition affecting the skeletal muscles of an inbred C57BL ...
De Biase D., Pagano T. B., Malanga D., Russo V., Piegari G., d'Aquino I., Iovane V., Scarfo M., Papparella S., Wojcik S., Paciello O.   +10 more
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Outbred, UM-HET3 mice have greater metabolic and arterial function than inbred, C57BL/6J mice

Physiology, 2023
In recent years, UM-HET3 mice have become more commonly used in biomedical research. UM-HET3 mice are an outbred, genetically diverse strain of mice that is produced by crossing four inbred strains: BALB/cByJ, C57BL/6J, C3H/HeJ, and DBA/2J. Notably, the UM-HET3 strain is used by the National Institute on Aging Interventions Testing Program to ...
Daniel Machin, Jennifer Berg Sen, Zhuoxin Li, Mostafa Sabouri, Christina Deacon, Joseph Bernardo, Xiangyu Zheng   +6 more
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Genetic control of hepatocarcinogenesis in C57BL/6J and C3H/HeJ inbred mice

Carcinogenesis, 1986
Treatment of newborn male C3H/HeJ mice with N,N-diethyl-nitrosamine (DEN) or N-ethyl-N-nitrosourea (ENU) resulted in the induction of hepatocellular adenomas and carcinomas with a mean number of tumors per animal that was approximately 20- to 50-fold higher than that for similarly treated C57BL/6J male mice.
N R, Drinkwater, J J, Ginsler
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Alveolar Process Anabolic Activity in C3H/HeJ and C57BL/6J Inbred Mice

Journal of Periodontology, 2008
Background: The purpose of this study was to characterize bone activity of the alveolar process in C3H/HeJ (C3H) and C57BL/6J (B6) inbred mice. Based on observations in other animal species, we hypothesized that the bone‐formation rate/bone surface (BFR/BS) is greater in the alveolar process compared to the body of the mandible and that the bone ...
Isaac F, Meta, Soledad A, Fernandez, Parul, Gulati, Sarandeep S, Huja   +3 more
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Discriminative Stimulus Effects of Ethanol in C57BL/6J and DBA/2J Inbred Mice

Alcoholism: Clinical and Experimental Research, 2002
Background: Two of the most widely used mouse strains for studying the behavioral effects of ethanol are C57BL/6J (B6) and DBA/2J (D2) mice. These strains exhibit marked differences in behavioral and physiological responses to ethanol. The subjective discriminative stimulus effects of ethanol may play a role in ethanol abuse, but the discriminative ...
Keith L, Shelton, Kathleen A, Grant
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Complete sequence of a hepatic cirrhosis inbred C57BL/6 mice model mitochondrial genome

Mitochondrial DNA Part A, 2014
In the present work we undertook the complete mitochondrial genome sequencing of an important hepatic cirrhosis model inbred C57BL/6 strain for the first time. Its mitogenome was 16,312 bp and coding 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes. A total of 96 SNPs were examined when compared to reference BN sequence.
Xiao-Ling, Jiang, Qiao, Feng, Wei-Hong, Li, Min, Xu, Jun-Sheng, Kang, Li-Xin, Wei   +5 more
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Casein and 3-methylcholanthrene carcinogenesis in inbred C57BL/6Os female mice.

Journal of the National Cancer Institute, 1977
Groups of inbred C57BL/6Os female mice were subjected to one of the following -reatments: 1) subamyloidogenic administration of sodium caseinate (C group); 2) four intragastric intubations of 0.25 mg 3-methylcholanthrene (MCA) (MCA group); 3) a sodium caseinate injection followed by MCA (C-MCA group); or 4) MCA followed by a soidum caseinate injection (
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