Results 81 to 90 of about 13,850 (186)

Microbial influences on severity and sex bias of systemic autoimmunity

Immunological Reviews, Volume 325, Issue 1, Page 64-76, August 2024.
Summary Commensal microbes have the capacity to affect development and severity of autoimmune diseases. Germ‐free (GF) animals have proven to be a fine tool to obtain definitive answers to the queries about the microbial role in these diseases. Moreover, GF and gnotobiotic animals can be used to dissect the complex symptoms and determine which are ...
Jean Lee, Derek Reiman, Samara Singh, Anthony Chang, Laurence Morel, Alexander V. Chervonsky   +5 more
wiley   +1 more source

Impaired myoblast differentiation and muscle IGF‐1 receptor signaling pathway activation after N‐glycosylation inhibition

The FASEB Journal, Volume 38, Issue 13, 15 July 2024.
N‐glycosylation inhibitions by Tunicamycin (TUN) or by knockdown of phosphomannomutase 2 (PMM2) gene block the C2C12 myoblast fusion and impair the myogenic program. TUN treatment decreased myogenic markers and increased atrophy markers in muscles of WT and MLC/mIgf‐1 mice, which overexpress muscle Igf‐1Ea mRNA isoform.
Giosuè Annibalini, Laura Di Patria, Giacomo Valli, Matteo Bocconcelli, Roberta Saltarelli, Lorenzo Ferri, Laura Barberi, Fabiana Fanelli, Amelia Morrone, Rita Barone, Renzo Guerrini, Antonio Musarò, Vilberto Stocchi, Elena Barbieri   +13 more
wiley   +1 more source

DBAS: A Deployable Bandwidth Aggregation System [PDF]

arXiv, 2012
The explosive increase in data demand coupled with the rapid deployment of various wireless access technologies have led to the increase of number of multi-homed or multi-interface enabled devices. Fully exploiting these interfaces has motivated researchers to propose numerous solutions that aggregate their available bandwidths to increase overall ...
arxiv  

Adenylyl cyclase 2 expression and function in neurological diseases

CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.
Mutations and expression changes of adenylyl cyclase 2 (Adcy2), a CNS‐enriched enzyme that converts ATP to cAMP, are associated with several neurodegenerative and psychiatric disorders. Abstract Adenylyl cyclases (Adcys) catalyze the formation of cAMP, a secondary messenger essential for cell survival and neurotransmission pathways in the CNS.
Marsilla Gray, Kevin R. Nash, Yao Yao
wiley   +1 more source

Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion

Molecular Metabolism, 2022
Objectives: Glucagon secretion to stimulate hepatic glucose production is the first line of defense against hypoglycemia. This response is triggered by so far incompletely characterized central hypoglycemia-sensing mechanisms, which control autonomous ...
Alexandre Picard, Xavier Berney, Judit Castillo-Armengol, David Tarussio, Maxime Jan, Ana Rodriguez Sanchez-Archidona, Sophie Croizier, Bernard Thorens   +7 more
doaj  

Genetic architecture of atherosclerosis dissected by QTL analyses in three F2 intercrosses of apolipoprotein E-null mice on C57BL6/J, DBA/2J and 129S6/SvEvTac backgrounds.

PLoS ONE, 2017
Quantitative trait locus (QTL) analyses of intercross populations between widely used mouse inbred strains provide a powerful approach for uncovering genetic factors that influence susceptibility to atherosclerosis.
Natalia Makhanova, Andrew P Morgan, Yukako Kayashima, Andrei Makhanov, Sylvia Hiller, Svetlana Zhilicheva, Longquan Xu, Fernando Pardo-Manuel de Villena, Nobuyo Maeda   +8 more
doaj   +1 more source

Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice

Behavioral and Brain Functions, 2011
Background The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both ...
Grabowski-Boase Laura, Eisener-Dorman Amy F, Tarantino Lisa M   +2 more
doaj   +1 more source

Energy Balance in Cell Phone Radiofrequency Radiation Exposed Mice and Rats [PDF]

arXiv, 2019
The National Toxicology Program exposed mice and rats to cell phone radiofrequency radiation. They observer cancers in male rats but not in male mice and different increases in body temperature between mice and rats using identical frequency and intensity exposures.
arxiv  

A Gravitational Redshift Determination of the Mean Mass of White Dwarfs. DBA and DB Stars [PDF]

, 2012
We measure apparent velocities (v_app) of absorption lines for 36 white dwarfs (WDs) with helium-dominated atmospheres -- 16 DBAs and 20 DBs -- using optical spectra taken for the European Southern Observatory SN Ia progenitor survey (SPY). We find a difference of 6.9+/-6.9 km/s in the average apparent velocity of the H-alpha lines versus that of the ...
arxiv   +1 more source

Genetic analysis of cholesterol accumulation in inbred mice

Journal of Lipid Research, 2001
Genetic linkage analysis in the laboratory mouse identified chromosomal regions containing genes that contribute to cholesterol accumulation in the liver and plasma.
Margrit Schwarz, Daphne L. Davis, Bertrand R. Vick, David W. Russell   +3 more
doaj