Results 121 to 130 of about 106,084 (256)

Evaluation of Type 1 Error Rates in Duplex Sequencing for Mutagenicity Testing Using Vehicle Control Data and Simulation Analyses

Environmental and Molecular Mutagenesis, Volume 67, Issue 5-7, June‐August 2026.
ABSTRACT Accurate mutation detection and quantification are crucial for understanding mutagenesis and its potential health implications. Traditional in vivo mutagenicity assays, such as the transgenic rodent gene mutation assay, are limited by their focus on single reporter genes and inability to efficiently generate mutation spectra.
Andrew Williams, Shaofei Zhang, Dingzhou Li, Wen Sun, Maik J. Schuler, Francesco Marchetti, Carole L. Yauk   +6 more
wiley   +1 more source

Identifying reliable traits across laboratory mouse exploration arenas: A meta-analysis

, 2012
This study is a meta-analysis of 367 mice from a collection of behaviour neuroscience and behaviour genetic studies run in the same lab in Zurich, Switzerland.
Rime Madani, Michael J. Galsworthy, Hans-Peter Lipp   +2 more
core   +1 more source

Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar Typhimurium infection

, 2003
Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated TLR-4) in response to Salmonella infection.
Maskell, Duncan J, Foster, Neil, Tötemeyer, Sabine, Kaiser, Pete, Bryant, Clare E   +4 more
core  

Vipr2 Gene Expression Is Upregulated in the Nucleus Accumbens of Spontaneous Hypertensive Rats During Early Life

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Expression of the VIP/PACAP receptor gene, Vipr2, was selectively upregulated in the nucleus accumbens of spontaneous hypertensive rats (SHRs), an animal model of ADHD, with no changes observed in DNA methylation levels at the CpG islands of the gene. This region‐specific overexpression may contribute to ADHD‐related behaviors in SHRs.
Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yabe   +3 more
wiley   +1 more source

Strain specific behavioral and physiological responses to constant light in male CBA/J and CBA/CaJ mice

Sleep Science
Objective:: Being visually impaired increases the likelihood of sleep disorders and altered behavior. This study investigated physiological and behavioral differences in two similar mice substrains when exposed to constant light (LL) - CBA/J with retinal
Hannah V Deane, Holly A Concepcion, Avery E Gatewood, Janessa Quintana, Joseph A Seggio   +4 more
doaj   +1 more source

Opposing Association of Lung Neutrophils and PD‐L1+ Monocytes in Age‐Related Severity of SARS‐CoV‐2 Infection

Aging Cell, Volume 25, Issue 6, June 2026.
Aging skews pulmonary myeloid responses during acute SARS‐CoV‐2 infection toward severe disease. Disease progression is characterized by excessive lung neutrophil accumulation together with impaired activation of classical monocytes, including a defect in PD‐L1 upregulation.
Serban Morosan, Clémence Granier, Noëlline Guillou, Selma Bennacer, Eléonore Weber‐Delacroix, Julianne Peronnet, François Lanthiez, Sandrine Barthelemy, Christelle Enond, Jean‐Luc Diehl, Elena Paillaud, Carine El‐Sissy, Anne‐Geneviève Marcelin, Vincent Calvez, Stéphane Marot, Amélie Guihot, Christophe Parizot, Karim Dorgham, Guy Gorochov, Christophe Combadière, Alexandre Boissonnas   +20 more
wiley   +1 more source

The Inflammatory Response in the Murine Ovalbumin‐Induced Skin Inflammation Model Is Robust Despite Major Gut Microbiota Differences

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Valid pre‐clinical animal models are essential for effective drug development in inflammatory skin diseases like atopic dermatitis. Most murine models exhibit low‐to‐moderate inflammatory responses with significant variability, undermining their validity and contributing to high drug attrition rates.
Ida Wang Henriksen, Christina Bartholdy, Janne Koch, Denitsa Vladimirova Stefanova, Camilla Hartmann Friis Hansen, Axel Kornerup Hansen   +5 more
wiley   +1 more source

Genetic Architecture of Addiction‐Relevant Behaviors in Outbred Sprague–Dawley Rats Reveals Loci for Anxiety‐Like and Nociceptive Traits

Genes, Brain and Behavior, Volume 25, Issue 3, June 2026.
Genome‐wide association analyses in outbred Sprague–Dawleys identified loci for anxiety‐like and nociceptive behavior on chromosomes 1, 14, and 17, which are distinct from facets of exploratory locomotion significant in our GWAS of a F2 intercross of selectively bred high‐ and low‐responder (to a novel environment) Sprague–Dawleys.
Apurva S. Chitre, Elaine K. Hebda‐Bauer, Michael A. Emery, Fei Li, Khai‐Minh Nguyen, Yizhi Wang, Riyan Cheng, Oksana Polesskaya, Stanley J. Watson Jr, Jun Li, Huda Akil, Abraham A. Palmer   +11 more
wiley   +1 more source

Infections with a Malaysian dog strain of Ancylostoma ceylanicum in outbred, inbred and immunocompromised mice

, 1983
The course of infection with a Malaysian dog strain of Ancylostoma ceylanicum was investigated in 15 inbred strains of mice, in outbred and inbred mice immunosuppressed with prednisolone, and in immuno-deficient hypothymic mice.
S., H. J., Mitchella, G. F., Grove, D. I., Whitten, L. K., Carroll, S. M.   +4 more
core   +1 more source

The transcription factors TaABI4 and TaNAC‐A1 fine‐tune TaCYP94‐A1 transcription to modulate seed dormancy in wheat

Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1845-1864, June 2026.
A module involving the transcription factors TaABI4 and TaNAC‐A1, and the cytochrome P450 TaCYP94‐A1 precisely regulates seed dormancy levels through plant hormone crosstalk, providing targets for improving resistance to pre‐harvest sprouting in wheat.
Litian Zhang, Yuhui Fang, Yunfei Zhou, Xianlai Nie, Shujun Cao, Wei Gao, Yu Wang, Lianghua Dai, Lin Ye, Jie Lu, Chuanxi Ma, Cheng Chang, Haiping Zhang   +12 more
wiley   +1 more source