Results 101 to 110 of about 106,084 (256)

Learning and memory with neuropathic pain : impact of old age and progranulin deficiency [PDF]

, 2013
Persistent neuropathic pain is a frequent consequence of peripheral nerve injuries, particularly in the elderly. Using the IntelliCage we studied if sciatic nerve injury obstructed learning and memory in young and aged mice, each in wild type and ...
Irmgard eTegeder, Vannoni, Elisabetta, Annett eHäussler, Irmgard Tegeder, Wolfer, David P., Elisabetta Vannoni, David P. Wolfer, Tegeder, Irmgard, Wolfer, David P, Elisabetta eVannoni, Annett Häussler, Häussler, Annett, Boris eAlbuquerque, Boris Albuquerque, Albuquerque, Boris, David P Wolfer, Wolfer, David Paul; id_orcid   +16 more
core   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

The genetic architecture of NAFLD among inbred strains of mice

eLife, 2015
To identify genetic and environmental factors contributing to the pathogenesis of non-alcoholic fatty liver disease, we examined liver steatosis and related clinical and molecular traits in more than 100 unique inbred mouse strains, which were fed a diet
Simon T Hui, Brian W Parks, Elin Org, Frode Norheim, Nam Che, Calvin Pan, Lawrence W Castellani, Sarada Charugundla, Darwin L Dirks, Nikolaos Psychogios, Isaac Neuhaus, Robert E Gerszten, Todd Kirchgessner, Peter S Gargalovic, Aldons J Lusis   +14 more
doaj   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.

PLoS Genetics
The laboratory mouse has served as the premier animal model system for both basic and preclinical investigations for over a century. However, laboratory mice capture only a subset of the genetic variation found in wild mouse populations, ultimately ...
Beth L Dumont, Daniel M Gatti, Mallory A Ballinger, Dana Lin, Megan Phifer-Rixey, Michael J Sheehan, Taichi A Suzuki, Lydia K Wooldridge, Hilda Opoku Frempong, Raman Akinyanju Lawal, Gary A Churchill, Cathleen Lutz, Nadia Rosenthal, Jacqueline K White, Michael W Nachman   +14 more
doaj   +1 more source

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source

High‐Carbohydrate Diet Enhances Peripheral Nerve Regeneration via Hemoglobin Upregulation in Schwann Cells

Food Frontiers, Volume 7, Issue 4, July 2026.
A short‐term high‐carbohydrate diet enhances peripheral nerve regeneration more effectively than high‐protein or high‐fat diets by upregulating hemoglobin genes in Schwann cells. Increased hemoglobin promotes Schwann cell proliferation and migration, facilitating nerve repair.
Shiying Li, Dong Liu, Lin Yu, Yuanyuan Chen, Fuqian Zhang, Xuchao Yan, Yang Qian, Mingwen Zhang, Tianling Song, Jing Zhang, Guifang Wang, Xin Wang, Chunhong Xue, Chen Chen, Guowei Le, Caiping Wang, Dandan Chu   +16 more
wiley   +1 more source

The Genoeconomics of Impulsive Intertemporal Choice: A Critical Review

Journal of the Experimental Analysis of Behavior, Volume 126, Issue 1, July 2026.
Abstract Dr. Warren Bickel tirelessly investigated delay discounting (DD), a behavioral economic index of impulsive decision making, as a determinant of numerous health outcomes. Among the factors that contribute to a person's level of DD, a burgeoning body of research has illuminated its genetic foundations and the extent to which it may be a ...
Wei Q. Deng, Kyla L. Belisario, Amanda Doggett, Mahmoud Elsayed, Alysha Cooper, James MacKillop   +5 more
wiley   +1 more source

Trps1 differentially modulates the bone mineral density between male and female mice and its polymorphism associates with BMD differently between women and men.

PLoS ONE, 2014
The objective of our study was to identify genetic factors that regulate bone mineral density (BMD) in mice using well defined recombinant inbred strains. For this purpose we chose the BXD recombinant inbred (RI) strains derived from progeny of the C57BL/
Lishi Wang, Wenli Lu, Lei Zhang, Yue Huang, Rachel Scheib, Xiaoyun Liu, Linda Myers, Lu Lu, Charles R Farber, Gaifen Liu, Cong-Yi Wang, Hongwen Deng, Robert W Williams, Yongjun Wang, Weikuan Gu, Yan Jiao   +15 more
doaj   +1 more source

WSB.APP/PS1 mice develop age‐dependent cerebral amyloid angiopathy, cerebrovascular dysfunction, and white matter deficits

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Cerebrovascular deficits, including cerebral amyloid angiopathy (CAA), play a key role in Alzheimer's disease (AD) pathogenesis. Here, we characterize the susceptibility of the WSB/EiJ genetic context to human AD‐relevant cerebrovascular phenotypes. METHODS CAA and parenchymal plaque analysis and in vivo neurovascular imaging were
Olivia J. Marola, Asli Uyar, Kelly J. Keezer, Juan Antonio K. Chong Chie, Kevin J. Elk, Abigail E. Cullen, Kierra Eldridge, Scott Persohn, Jonathan Nyandu Kanyinda, Jennifer D. Whitesell, Julie A. Harris, Paul Salama, Ashley E. Walker, Gregory W. Carter, Michael Sasner, Paul R. Territo, Gareth R. Howell, Kristen D. Onos   +17 more
wiley   +1 more source