Results 91 to 100 of about 106,274 (236)

“Yet the Problem Remains”: Why Genetic Determinism Still Haunts Biomedical Research

Bioethics, EarlyView.
ABSTRACT After the horrors of the Holocaust and its connections to eugenics were revealed to the world, many post‐war population geneticists sought to establish rhetorical distance from the Nazi's state‐led campaigns, without abandoning their belief that actively shaping the population's genetics would produce a prosperous society.
Christopher R. Donohue, Ian A. Myles
wiley   +1 more source

Induction of Hepatomas by Thiouracil in Inbred Strains of Mice.

Experimental Biology and Medicine, 1963
SummaryFeeding a diet containing 0.3% of thiouracil (TU) by dry weight for 18 months to a subline of C3H mice produced a nearly 100% incidence of hepatoma in both sexes. Controls given no TU had definite but significantly lower incidence of this tumor. When the inbred strain of mice TM was used, no hepatomas were observed in experimental nor in control
openaire   +2 more sources

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

British Journal of Haematology, EarlyView.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi, Nandakumar Natarajan, Kathryn E. Dickerson, Richard A. Voit   +3 more
wiley   +1 more source

Standardized nomenclature for inbred strains of mice: sixth listing. [PDF]

, 1976
Rules for designating inbred strains of mice are presented, along with a list of strains with their origins and characteristics, a table of biochemical polymorphisms, and standard subline ...
Staats, J
core  

Interactive effects of protein nutrition, genetic growth potential and heligmosomoides bakeri infection pressure on resilience and resistance in mice [PDF]

, 2011
The ability of animals to cope with an increasing parasite load, in terms of resilience and resistance, may be affected by both nutrient supply and demand.
Houdijk, Jos G M, Allen, J.E., JENNIFER C. COLTHERD, Bunger, L., Coltherd, JC, Babayan, SA, Allen, JE, JOS G. M. HOUDIJK, JUDITH E. ALLEN, SIMON A. BABAYAN, Babayan, S.A., Houdijk, JGM; id_orcid, Kyriazakis, I., Allen, Judith E, Coltherd, J.C., Houdijk, J.G.M., Coltherd, Jennifer C, Kyriazakis, Ilias, ILIAS KYRIAZAKIS, Babayan, Simon A, LUTZ BÜNGER, Bunger, L, Kyriazakis, I, Bünger, Lutz   +23 more
core   +1 more source

DNA Methylation Changes More Slowly Than Physiological States in Response to Weight Loss in Genetically Diverse Mouse Strains

Frontiers in Endocrinology, 2019
Responses to a high fat, high sucrose (HFHS) diet vary greatly among inbred strains of mice. We sought to examine the epigenetic (DNA methylation) changes underlying these differences as well as variation in weight loss when switched to a low-fat chow ...
Chantle R. Edillor, Brian W. Parks, Margarete Mehrabian, Aldons J. Lusis, Aldons J. Lusis, Matteo Pellegrini   +5 more
doaj   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Post‐Transplant Bendamustine as a Platform for Immune Modulation After Allogeneic Hematopoietic Cell Transplantation

European Journal of Haematology, EarlyView.
ABSTRACT Post‐transplant cyclophosphamide (PT‐CY) remains the standard of care for graft‐versus‐host disease (GvHD) prophylaxis in haploidentical hematopoietic cell transplantation (HCT), yet relapse, delayed immune reconstitution, infections, and organ toxicity represent persistent and clinically meaningful limitations.
Megan J. Cracchiolo, Richard J. Simpson, Emmanuel Katsanis   +2 more
wiley   +1 more source

Standardized Nomenclature for Inbred Strains of Mice: eighth listing. [PDF]

, 1985
This paper presents a list of inbred strains of mice with their origins and characteristics, and a list of standard subline ...
Staats, J
core  

Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram‐negative septic acute kidney injury

Experimental Physiology, EarlyView.
Abstract Renal arterial infusion of tempol (RAT) at the onset of Gram‐negative sepsis can prevent sepsis‐induced medullary tissue hypoxia and acute kidney injury (AKI). However, it is not known whether treatment with tempol at a clinically relevant time point of sepsis is similarly effective. Thus, we examined whether tempol can reverse renal medullary
Rachel Peiris, Anton Trask‐Marino, Alemayehu Jufar, Ashenafi H. Betrie, Adam Southon, Sally G. Hood, Rinaldo Bellomo, Abraham H. Hulst, Clive N. May, Connie P. C. Ow, Yugeesh R. Lankadeva   +10 more
wiley   +1 more source