Results 91 to 100 of about 1,877,211 (239)
ABSTRACT Post‐transplant cyclophosphamide (PT‐CY) remains the standard of care for graft‐versus‐host disease (GvHD) prophylaxis in haploidentical hematopoietic cell transplantation (HCT), yet relapse, delayed immune reconstitution, infections, and organ toxicity represent persistent and clinically meaningful limitations.
Megan J. Cracchiolo +2 more
wiley +1 more source
Does tolerance to ethanol-induced ataxia explain the sensitized response to ethanol?
Under conditions of repeated exposure to ethanol, a sensitized locomotor stimulant response develops in some strains of mice. It has been hypothesized that the sensitized response is a consequence of tolerance development to the sedative/incoordinating ...
Cheryl Reed +4 more
doaj +1 more source
ABSTRACT Objective This study aims to investigate the effect of sex, anesthesia administration method, lymphatic physiological asymmetry, and strain on popliteal lymphatic collecting vessel contractile function and transport in effort to create a research comparison standard for experimentations using rat popliteal lymphatics.
Sophia Mavris +5 more
wiley +1 more source
Evaluation of an outbred mouse model for Francisella tularensis vaccine development and testing.
Francisella tularensis (Ft) is a biothreat agent for which there is no FDA-approved human vaccine. Currently, there are substantial efforts underway to develop both vaccines and the tools to assess these vaccines.
Raju Sunagar +5 more
doaj +1 more source
Evaluating the Validity of Model Organisms: A Review and a New Framework for Biologists
This article provides an overview on model organisms and proposes a new framework for assessing the extent to which it is justified to generalize the results obtained from a given organism. It covers both studies of human diseases and those focused on general biological processes. The first part of the article is a review on model organisms.
Héloïse Athéa, Nicolas Heck
wiley +1 more source
NONcNZO10/LtJ and TALLY‐HO/JngJ Mice as Novel Models of Diabetic Peripheral Neuropathy
Animal models of diabetic peripheral neuropathy (DPN) are essential for understanding disease mechanisms and evaluating therapies. We characterized two polygenic mouse strains, RCS10 and TH, and found that both developed obesity, hyperglycemia, dyslipidemia, and DPN.
Stéphanie A. Eid +10 more
wiley +1 more source
Normal mandibular morphology of inbred mouse strains
Indiana University-Purdue University Indianapolis (IUPUI)Even though the molecular events and pathways that underlie craniofacial development and morphogenesis are not fully understood, it is accepted that their orchestration is influenced by the ...
Edwards, Michelle Halum
core +1 more source
Standardized nomenclature for inbred strains of mice: sixth listing.
Rules for designating inbred strains of mice are presented, along with a list of strains with their origins and characteristics, a table of biochemical polymorphisms, and standard subline ...
Staats, J
core +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar Typhimurium infection [PDF]
Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated TLR-4) in response to Salmonella infection.
Maskell, Duncan J +4 more
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