Results 71 to 80 of about 1,877,211 (239)
British Journal of Haematology, EarlyView.Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi +3 more
wiley +1 more source
Teratogenesis in Inbred Strains of Mice [PDF]
, 1966 The purpose of this investigation is to determine if differences exist between four inbred strains of mice in susceptibility to the drug ...
Morgan, Robert A.
core
Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity
BMC Neuroscience, 2005 Background Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body.
Wu Fangbai +4 more
doaj +1 more source
Modeling the Genetic Basis of Individual Differences in Susceptibility to Gulf War Illness
Brain Sciences, 2020 Between 25% and 30% of the nearly one million military personnel who participated in the 1991 Persian Gulf War became ill with chronic symptoms ranging from gastrointestinal to nervous system dysfunction.
Byron C. Jones +10 more
doaj +1 more source
Induction of Hepatomas by Thiouracil in Inbred Strains of Mice.
Experimental Biology and Medicine, 1963 SummaryFeeding a diet containing 0.3% of thiouracil (TU) by dry weight for 18 months to a subline of C3H mice produced a nearly 100% incidence of hepatoma in both sexes. Controls given no TU had definite but significantly lower incidence of this tumor. When the inbred strain of mice TM was used, no hepatomas were observed in experimental nor in control
openaire +2 more sources
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice.
, 1990 Female mice of 16 inbred mouse strains were fed an atherogenic diet for 14 weeks and were then evaluated for atherosclerotic lesions in the aorta. Strains C57BL/6, C57BR/cd, C57L, and SM were very susceptible to atherosclerosis, with lesion area ...
Ishida, B Y +4 more
core +3 more sources
Cancer Science, EarlyView.Koumine binds IGF2BP3 and promotes its proteasomal degradation, reducing m6A on EED mRNA, accelerating EED decay, lowering H3K27me3, and promoting IRF transcription, thereby restoring MHC‐I and enhancing CD8+ T cell killing. ABSTRACT Resistance to immune checkpoint blockade in gastric cancer often arises from defective antigen presentation due to MHC‐I
Qiu Hongqiang +10 more
wiley +1 more source
European Journal of Translational Myology, 2017 Physical activity has multiple beneficial effects in the physiology and pathology of the organism. In particular, we and other groups have shown that running counteracts cancer cachexia in both humans and rodents.
Dario Coletti +2 more
doaj +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Animal models of prediabetes (Pre‐DM) are essential for studying metabolic disease and testing therapies, yet high‐fat diet (HFD) and HFD‐plus‐streptozotocin (STZ) protocols vary in feeding duration, STZ dose, and diagnostic criteria and rarely account for sex.
Min Xu +7 more
wiley +1 more source