Results 71 to 80 of about 106,274 (236)

SPERMATOGENESIS INDICES IN INBRED STRAINS DD/HE AND BALB/CLAC AND THEIR F1 RECIPROCAL CROSSES

Вавиловский журнал генетики и селекции, 2014
We have shown that among 13 inbred mice strains males the DD/He strain has the lowest proportion of mobile sperm and moderate sperm count and proportion of abnormal sperm heads.
M. A. Kleshchev, L. V. Osadchuk, A. V. Osadchuk   +2 more
doaj  

The collaborative cross strains and their founders vary widely in cocaine-induced behavioral sensitization

Frontiers in Behavioral Neuroscience, 2022
Cocaine use and overdose deaths attributed to cocaine have increased significantly in the United States in the last 10 years. Despite the prevalence of cocaine use disorder (CUD) and the personal and societal problems it presents, there are currently no ...
Sarah A. Schoenrock, Sarah A. Schoenrock, Leona Gagnon, Leona Gagnon, Ashley Olson, Ashley Olson, Michael Leonardo, Michael Leonardo, Vivek M. Philip, Vivek M. Philip, Hao He, Hao He, Laura G. Reinholdt, Laura G. Reinholdt, Stacey J. Sukoff Rizzo, Stacey J. Sukoff Rizzo, Stacey J. Sukoff Rizzo, James D. Jentsch, James D. Jentsch, Elissa J. Chesler, Elissa J. Chesler, Lisa M. Tarantino, Lisa M. Tarantino, Lisa M. Tarantino   +23 more
doaj   +1 more source

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Analysis of energy expenditure and behavioral characteristics in different mouse strains under normal and disease conditions

Animal Models and Experimental Medicine, EarlyView.
Mouse metabolic and behavioral phenotypes are tightly linked to strain, age and disease state, with distinct dysregulation in each disease model, underscoring the need for standardized preclinical experimental conditions. Abstract Background Metabolic and behavioral traits in mice exhibit substantial variability across strains, ages, and disease states,
Jiacheng Zeng, Yuanjun Ji, Yan Zou, Jing Tan, Teng Wu, Conghui Shen, Tongsheng Huang, Shijie Xiong, Mengying Liu, Maoquan Yang, Jingwei Lai, Jiangwei Ma, Junhong Wan, Xinlu Fu, Jiang Qian, Hui Li, Ludong Yuan, Weibin Cai   +17 more
wiley   +1 more source

A Natural Occurring Mouse Model with Adgrv1 Mutation of Usher Syndrome 2C and Characterization of its Recombinant Inbred Strains

Cellular Physiology and Biochemistry, 2018
Background/Aims: Our laboratory discovered a Kunming mouse with enormous electroretinogram (ERG) defects. Its auditory brainstem response (ABR) threshold was significantly elevated and closely resembled the features of Usher syndrome (USH).
Weiming Yan, Pan Long, Tao Chen, Wei Liu, Lu Yao, Ze Ren, Xiangqian Li, Jiancong Wang, Junhui Xue, Ye Tao, Lei Zhang, Zuoming Zhang   +11 more
doaj   +1 more source

Born this way: Does variation in perinatal limb bone morphology predict adult locomotor repertoire in primates?

The Anatomical Record, EarlyView.
Abstract Primates show a high degree of locomotor diversity that engenders similar variance in limb bone cross‐sectional geometry and bending strength: leaping primates have stronger hindlimb bones whereas suspensory species have stronger forelimb bones.
Angela M. Mossor, Jeremy Busken, Lorna Benden, Ethan Mardovin, Andrew Bostick, Grégoire Boulinguez‐Ambroise, Timothy D. Smith, Jesse W. Young   +7 more
wiley   +1 more source

Teratogenesis in Inbred Strains of Mice [PDF]

, 1966
The purpose of this investigation is to determine if differences exist between four inbred strains of mice in susceptibility to the drug ...
Morgan, Robert A.
core  

Elucidating the characteristics of Mx1 and resistance to influenza A virus subtype H1N1 in the newly developed KWM/Hym mice

Laboratory Animal Research, 2022
Background Inbred mice have several advantages, including genetic similarity to humans, a well-established gene manipulation system, and strong tolerance to inbreeding.
Hajin Nam, Boyoung Kim, Avishekh Gautam, Yoo Yeon Kim, Eun Sun Park, Jong Sun Lee, Hyung-Joo Kwon, Je Kyung Seong, Jun Gyo Suh   +8 more
doaj   +1 more source

Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population

G3: Genes, Genomes, Genetics, 2023
Multiparental populations (MPPs) encompass greater genetic diversity than traditional experimental crosses of two inbred strains, enabling broader surveys of genetic variation underlying complex traits. Two such mouse MPPs are the Collaborative Cross (CC)
Gregory R Keele
doaj   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source