Results 61 to 70 of about 106,274 (236)
Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus
Neurobiology of Disease, 2012 Mouse strains differ from one another in their susceptibility to seizure-induced excitotoxic cell death. Previously, we have demonstrated that mature inbred strains of mice show remarkable genetic differences in susceptibility to the neuropathological ...
P. Elyse Schauwecker
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Advanced Science, EarlyView.This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu +7 more
wiley +1 more source
Inbred lab mice are not isogenic:Genetic variation within inbred strains used to infer the mutation rate per nucleotide site [PDF]
, 2020 For over a century, inbred mice have been used in many areas of genetics research to gain insight into the genetic variation underlying traits of interest. The generalizability of any genetic research study in inbred mice is dependent upon all individual
Chebib, Jobran; id_orcid +9 more
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Genetics and Molecular Biology, 2007 The mouse (Mus musculus) bone marrow micronucleus test was carried out using 24 outbred National Institutes of Health (NIH) mice, 24 inbred Swiss Webster (CFW) mice and 20 inbred Bagg albino/color locus Jackson (BALB/cJ) mice.
Ximena C. Abrevaya +2 more
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Advanced Science, EarlyView.This perspective contrasts the historical, linear progression of early AI with the dynamic, iterative nature of AI 4.0; and it describes the real‐world medical applications and the necessary evolution of laboratory infrastructure brought about by AI 4.0.
Weida Liu, Gary Peltz
wiley +1 more source
Individual strategies of aggressive and non-aggressive male mice in encounters with trained aggressive residents [PDF]
, 1992 To determine whether individual differences in offensive behaviour are related to differences in defensive behaviour, the responses of male wild house mice, Mus domesticus, of an aggressive and a non-aggressive line to defeat by physically stronger ...
Koolhaas, Jaap M., +7 more
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Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice
Memorias do Instituto Oswaldo Cruz, 1990 The murine model of chronic Chaga's myocardiopathy was developed in 201 inbred and outbred mice. The experimental groups consisted of 1st: 73 inbred AKR and A/J mice inoculated with one of the following.
Sonia G. Andrade
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Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco +2 more
wiley +1 more source
Placentophagia in Nonpregnant Nulliparous Mice: A Genetic Investigation [PDF]
, 1975 The genetic influence on the response of nonpregnant nulliparous mice to foster placenta was investigated. Two highly inbred strains (BALB/cBy and C57BL/6By), their F1 hybrids, a backcross generation, and seven recombinant-inbred strains derived from the
Kristal, M B +3 more
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Noninvasive determination of intraocular pressure (IOP) in nonsedated mice of 5 different inbred strains [PDF]
, 2007 BACKGROUND: Noninvasive intraocular pressure (IOP) measurement in mice is critically important for understanding the pathophysiology of glaucoma. Rebound tonometry is one of the methods that can be used for obtaining such measurements.
Nissirios, Nicholas +4 more
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