Results 41 to 50 of about 106,274 (236)

Behavioral Profiles of Genetically Selected Aggressive and Nonaggressive Male Wild House Mice in Two Anxiety Tests [PDF]

, 2000
Artificially selected aggressive (SAL) and non-aggressive (LAL) male house mice were tested in a hexagonal tunnel maze and light–dark preference (LD) box to determine if the bidirectional selection for aggressive behavior leads to a coselection for ...
Sluyter, Frans, Hogg, Sandy, Hof, Marleen, Steimer, Thierry, de Ruiter, Anne, Würbel, Hanno, Hogg, Sandy,, Sluyter, Frans,, Koolhaas, Jaap, Hof, Maleen,, Koolhaas, Jaap,, Steimer, Thierry,, Würbel, Hanno,, Ruiter, Anne de,   +13 more
core   +1 more source

Genetic analysis of intestinal cholesterol absorption in inbred mice

Journal of Lipid Research, 2001
A genetic mapping strategy was employed to identify chromosomal regions harboring genes that influence the absorption of intestinal cholesterol in the mouse.
Margrit Schwarz, Daphne L. Davis, Bertrand R. Vick, David W. Russell   +3 more
doaj   +1 more source

Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]

, 2000
The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim, Schlöndorff, Detlef   +1 more
core   +1 more source

Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice

Genome Biology, 2022
Background The laboratory mouse was domesticated from the wild house mouse. Understanding the genetics underlying domestication in laboratory mice, especially in the widely used classical inbred mice, is vital for studies using mouse models. However, the
Ming Liu, Caixia Yu, Zhichao Zhang, Mingjing Song, Xiuping Sun, Jaroslav Piálek, Jens Jacob, Jiqi Lu, Lin Cong, Hongmao Zhang, Yong Wang, Guoliang Li, Zhiyong Feng, Zhenglin Du, Meng Wang, Xinru Wan, Dawei Wang, Yan-Ling Wang, Hongjun Li, Zuoxin Wang, Bing Zhang, Zhibin Zhang   +21 more
doaj   +1 more source

A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

OncoImmunology, 2022
Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic ...
Justin B. Hackett, James E. Glassbrook, Maria C. Muñiz, Madeline Bross, Abigail Fielder, Gregory Dyson, Nasrin Movahhedin, Jennifer McCasland, Claire McCarthy-Leo, Heather M. Gibson   +9 more
doaj   +1 more source

A Behavioral Comparison of Four Inbred Strains of Mice [PDF]

, 2010
Isogenic, or inbred, mouse strains are currently the experimental subjects of choice in laboratory studies focused on genetics, pharmacology, and psychological issues.
Wood, Erin
core   +2 more sources

Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice

Frontiers in Immunology, 2017
Recent work has suggested that current mouse models may underrepresent the complexity of human immune responses. While most mouse immunology studies utilize inbred mouse strains, it is unclear if conclusions drawn from inbred mice can be extended to all ...
Matthew D. Martin, Derek B. Danahy, Stacey M. Hartwig, Stacey M. Hartwig, John T. Harty, John T. Harty, John T. Harty, Vladimir P. Badovinac, Vladimir P. Badovinac, Vladimir P. Badovinac   +9 more
doaj   +1 more source

Of mice and academics: examining the effect of openness on innovation [PDF]

, 2008
Scientific freedom and openness are hallmarks of academia: relative to their counterparts in industry, academics maintain discretion over their research agenda and allow others to build on their discoveries.
Fiona Murray, Aghion, Philippe, Scott Stern, Dewatripont, Mathias, Kolev, Julian, Kolev, J., Dewatripont, M., Stern, Scott, Philippe Aghion, Murray, F., Murray, Fiona, Julian Kolev, Mathias Dewatripont, Stern, S., Aghion, P.   +14 more
core   +1 more source

Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes

Journal of Lipid Research, 1995
A concept proposed by Berg (Berg, K. 1989. Arteriosclerosis. 9: I-50-I-58) is that a combination of level and variability genes determine an individual's overall plasma lipid levels and atherosclerotic risk.
E A Kirk, G L Moe, M T Caldwell, J A Lernmark, D L Wilson, R C LeBoeuf   +5 more
doaj   +1 more source

Variation in Host Resistance to Blastomyces dermatitidis: Potential Use of Genetic Reference Panels and Advances in Immunophenotyping of Diverse Mouse Strains

mBio, 2022
Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating variation in phenotype with allele in founder strains of wild ...
Elaine M. Kohn, Cleison Taira, Hanah Dobson, Lucas Dos Santos Dias, Uju Okaa, Darin L. Wiesner, Marcel Wüthrich, Bruce S. Klein   +7 more
doaj   +1 more source