Results 41 to 50 of about 1,877,211 (239)

Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice.

, 2004
Investigation of sequence variation in common inbred mouse strains has revealed a segmented pattern in which regions of high and low variant density are intermixed.
Keays, D, A, Jefferson, A, Brady, S, Flint, J, Copley, RR, Volpi, E., Keays, D.A., Jefferson, A., Mott, R, Bhomra, A, Miller, S., Mott, R., Copley, R.R., Flint, Jonathan, Yalcin, B., Yalcin, B, Bhomra, A., Fullerton, J, Flint, J., Fullerton, J., Keays, DA, Copley, R, R, Miller, S, Volpi, E, Brady, S.   +24 more
core   +1 more source

Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice

Behavioral and Brain Functions, 2011
Background The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both ...
Grabowski-Boase Laura, Eisener-Dorman Amy F, Tarantino Lisa M   +2 more
doaj   +1 more source

Glucose Absorption in Highly Inbred Strains of Mice.

Experimental Biology and Medicine, 1952
Conclusions1. Glucose absorption in the mouse has been studied. Increasing the concentration of administered solution results in an increase in the amount of glucose absorbed. 2. Glucose solutions of 75% concentration were absorbed somewhat more readily by mice of the C57 strain than by those of the A strain (p = 0.015). 3.
P F, FENTON, H M, DICKSON, G R, COWGILL
openaire   +2 more sources

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Individual strategies of aggressive and non-aggressive male mice in encounters with trained aggressive residents [PDF]

, 1992
To determine whether individual differences in offensive behaviour are related to differences in defensive behaviour, the responses of male wild house mice, Mus domesticus, of an aggressive and a non-aggressive line to defeat by physically stronger ...
Koolhaas, Jaap M.,, Oortmerssen, Geert A. van, Benus, Rensina F., Koolhaas, Jaap M., van Oortmerssen, G.A., Benus, R.F., Oortmerssen, Geert A. van,, Benus, Rensina F.,   +7 more
core   +1 more source

Evidence of a Large-Scale Functional Organization of Mammalian Chromosomes. [PDF]

PLoS Genetics, 2005
Evidence from inbred strains of mice indicates that a quarter or more of the mammalian genome consists of chromosome regions containing clusters of functionally related genes.
Petko M Petkov, Joel H Graber, Gary A Churchill, Keith DiPetrillo, Benjamin L King, Kenneth Paigen   +5 more
doaj   +2 more sources

Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus

Neurobiology of Disease, 2012
Mouse strains differ from one another in their susceptibility to seizure-induced excitotoxic cell death. Previously, we have demonstrated that mature inbred strains of mice show remarkable genetic differences in susceptibility to the neuropathological ...
P. Elyse Schauwecker
doaj   +1 more source

Hydronephrosis in inbred strains of mice with particular reference to the BRVR strain [PDF]

Laboratory Animals, 1973
Hydronephrosis occurred in 6 of the 13 inbred mouse strains maintained in the same colony. Its incidence was high only in the BRVR strain, where about half of the cases could only be detected microscopically. There was no concomitant infection even in severely abnormal BRVR kidneys and the incidence of the condition was not influenced by dietary ...
Taylor, D M, Fraser, H
openaire   +2 more sources

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source