Results 31 to 40 of about 1,877,211 (239)

Behavioral Profiles of Genetically Selected Aggressive and Nonaggressive Male Wild House Mice in Two Anxiety Tests [PDF]

, 2000
Artificially selected aggressive (SAL) and non-aggressive (LAL) male house mice were tested in a hexagonal tunnel maze and light–dark preference (LD) box to determine if the bidirectional selection for aggressive behavior leads to a coselection for ...
Sluyter, Frans, Hogg, Sandy, Hof, Marleen, Steimer, Thierry, de Ruiter, Anne, Würbel, Hanno, Hogg, Sandy,, Sluyter, Frans,, Koolhaas, Jaap, Hof, Maleen,, Koolhaas, Jaap,, Steimer, Thierry,, Würbel, Hanno,, Ruiter, Anne de,   +13 more
core   +1 more source

The influence of timeshift on ciradian rhythm of sensitivity to X-irradiation in mice [PDF]

, 1984
For two groups of male C3H mice an eastbound transmeridional flight was simulated by inducing a time shift of the L:D schedule of 8 hr. The assumed flight brought about a maxima) reduction of the daily light and dark span, respectively.
Arbogast, B., Gerbes, Alexander L.
core   +1 more source

Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]

, 2000
The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim, Schlöndorff, Detlef   +1 more
core   +1 more source

A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

OncoImmunology, 2022
Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic ...
Justin B. Hackett, James E. Glassbrook, Maria C. Muñiz, Madeline Bross, Abigail Fielder, Gregory Dyson, Nasrin Movahhedin, Jennifer McCasland, Claire McCarthy-Leo, Heather M. Gibson   +9 more
doaj   +1 more source

Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice

Frontiers in Immunology, 2017
Recent work has suggested that current mouse models may underrepresent the complexity of human immune responses. While most mouse immunology studies utilize inbred mouse strains, it is unclear if conclusions drawn from inbred mice can be extended to all ...
Matthew D. Martin, Derek B. Danahy, Stacey M. Hartwig, Stacey M. Hartwig, John T. Harty, John T. Harty, John T. Harty, Vladimir P. Badovinac, Vladimir P. Badovinac, Vladimir P. Badovinac   +9 more
doaj   +1 more source

A Behavioral Comparison of Four Inbred Strains of Mice [PDF]

, 2010
Isogenic, or inbred, mouse strains are currently the experimental subjects of choice in laboratory studies focused on genetics, pharmacology, and psychological issues.
Wood, Erin
core   +1 more source

Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes

Journal of Lipid Research, 1995
A concept proposed by Berg (Berg, K. 1989. Arteriosclerosis. 9: I-50-I-58) is that a combination of level and variability genes determine an individual's overall plasma lipid levels and atherosclerotic risk.
E A Kirk, G L Moe, M T Caldwell, J A Lernmark, D L Wilson, R C LeBoeuf   +5 more
doaj   +1 more source

Of mice and academics: examining the effect of openness on innovation [PDF]

, 2008
Scientific freedom and openness are hallmarks of academia: relative to their counterparts in industry, academics maintain discretion over their research agenda and allow others to build on their discoveries.
Fiona Murray, Aghion, Philippe, Scott Stern, Dewatripont, Mathias, Kolev, Julian, Kolev, J., Dewatripont, M., Stern, Scott, Philippe Aghion, Murray, F., Murray, Fiona, Julian Kolev, Mathias Dewatripont, Stern, S., Aghion, P.   +14 more
core   +1 more source

Variation in Host Resistance to Blastomyces dermatitidis: Potential Use of Genetic Reference Panels and Advances in Immunophenotyping of Diverse Mouse Strains

mBio, 2022
Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating variation in phenotype with allele in founder strains of wild ...
Elaine M. Kohn, Cleison Taira, Hanah Dobson, Lucas Dos Santos Dias, Uju Okaa, Darin L. Wiesner, Marcel Wüthrich, Bruce S. Klein   +7 more
doaj   +1 more source

Susceptibility differences of inbred strains of mice to blastomycosis [PDF]

Infection and Immunity, 1981
The susceptibility of inbred strains of mice to pulmonary blastomycosis was studied to derive information relevant to host resistance and genetic background. Initial studies with eight strains with various H-2 backgrounds revealed the C3H/HeJ strain to be highly susceptible and DBA/1J mice to be resistant. These observations were confirmed with various
Morozumi, P A, Helpern, J W, Stevens, D A   +2 more
openaire   +2 more sources