Results 31 to 40 of about 106,084 (256)

Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice

Frontiers in Immunology, 2017
Recent work has suggested that current mouse models may underrepresent the complexity of human immune responses. While most mouse immunology studies utilize inbred mouse strains, it is unclear if conclusions drawn from inbred mice can be extended to all ...
Matthew D. Martin, Derek B. Danahy, Stacey M. Hartwig, Stacey M. Hartwig, John T. Harty, John T. Harty, John T. Harty, Vladimir P. Badovinac, Vladimir P. Badovinac, Vladimir P. Badovinac   +9 more
doaj   +1 more source

Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice

Genome Biology, 2022
Background The laboratory mouse was domesticated from the wild house mouse. Understanding the genetics underlying domestication in laboratory mice, especially in the widely used classical inbred mice, is vital for studies using mouse models. However, the
Ming Liu, Caixia Yu, Zhichao Zhang, Mingjing Song, Xiuping Sun, Jaroslav Piálek, Jens Jacob, Jiqi Lu, Lin Cong, Hongmao Zhang, Yong Wang, Guoliang Li, Zhiyong Feng, Zhenglin Du, Meng Wang, Xinru Wan, Dawei Wang, Yan-Ling Wang, Hongjun Li, Zuoxin Wang, Bing Zhang, Zhibin Zhang   +21 more
doaj   +1 more source

A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

OncoImmunology, 2022
Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic ...
Justin B. Hackett, James E. Glassbrook, Maria C. Muñiz, Madeline Bross, Abigail Fielder, Gregory Dyson, Nasrin Movahhedin, Jennifer McCasland, Claire McCarthy-Leo, Heather M. Gibson   +9 more
doaj   +1 more source

Inter-strain differences of serotonergic inhibitory pain control in inbred mice

, 2010
Background: Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Albuquerque Boris, Irmgard Tegeder, Tegeder Irmgard, Laura Popp, Wijnvoord, Nina, Myrczek, Thekla, Tegeder, Irmgard, Wijnvoord Nina, Popp, Laura, Annett Häussler, Häussler, Annett, Nina Wijnvoord, Myrczek Thekla, Häussler Annett, Popp Laura, Boris Albuquerque, Albuquerque, Boris, Thekla Myrczek   +17 more
core   +1 more source

Of mice and academics: examining the effect of openness on innovation [PDF]

, 2008
Scientific freedom and openness are hallmarks of academia: relative to their counterparts in industry, academics maintain discretion over their research agenda and allow others to build on their discoveries.
Fiona Murray, Aghion, Philippe, Scott Stern, Dewatripont, Mathias, Kolev, Julian, Kolev, J., Dewatripont, M., Stern, Scott, Philippe Aghion, Murray, F., Murray, Fiona, Julian Kolev, Mathias Dewatripont, Stern, S., Aghion, P.   +14 more
core   +1 more source

Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes

Journal of Lipid Research, 1995
A concept proposed by Berg (Berg, K. 1989. Arteriosclerosis. 9: I-50-I-58) is that a combination of level and variability genes determine an individual's overall plasma lipid levels and atherosclerotic risk.
E A Kirk, G L Moe, M T Caldwell, J A Lernmark, D L Wilson, R C LeBoeuf   +5 more
doaj   +1 more source

Variation in Host Resistance to Blastomyces dermatitidis: Potential Use of Genetic Reference Panels and Advances in Immunophenotyping of Diverse Mouse Strains

mBio, 2022
Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating variation in phenotype with allele in founder strains of wild ...
Elaine M. Kohn, Cleison Taira, Hanah Dobson, Lucas Dos Santos Dias, Uju Okaa, Darin L. Wiesner, Marcel Wüthrich, Bruce S. Klein   +7 more
doaj   +1 more source

Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice

Behavioral and Brain Functions, 2011
Background The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both ...
Grabowski-Boase Laura, Eisener-Dorman Amy F, Tarantino Lisa M   +2 more
doaj   +1 more source

Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice.

, 2004
Investigation of sequence variation in common inbred mouse strains has revealed a segmented pattern in which regions of high and low variant density are intermixed.
Keays, D, A, Jefferson, A, Brady, S, Flint, J, Copley, RR, Volpi, E., Keays, D.A., Jefferson, A., Mott, R, Bhomra, A, Miller, S., Mott, R., Copley, R.R., Flint, Jonathan, Yalcin, B., Yalcin, B, Bhomra, A., Fullerton, J, Flint, J., Fullerton, J., Keays, DA, Copley, R, R, Miller, S, Volpi, E, Brady, S.   +24 more
core   +1 more source

Strain variation in spermatozoal glycosidases in inbred mice

Genetical Research, 1978
SUMMARYTen glycosidases were measured in suspensions of spermatozoa from the vasa deferentia of two inbred mouse strains and their intercrosses. Eight of these glycosidases were associated with the sperm cells and all of these showed genetical variation between the strains except α-l-fucosidase with optimal activity at pH 5·4.
Self, S J, Winchester, B G, Archer, J R
openaire   +2 more sources