Results 81 to 90 of about 106,084 (256)

DNA Methylation Changes More Slowly Than Physiological States in Response to Weight Loss in Genetically Diverse Mouse Strains

Frontiers in Endocrinology, 2019
Responses to a high fat, high sucrose (HFHS) diet vary greatly among inbred strains of mice. We sought to examine the epigenetic (DNA methylation) changes underlying these differences as well as variation in weight loss when switched to a low-fat chow ...
Chantle R. Edillor, Brian W. Parks, Margarete Mehrabian, Aldons J. Lusis, Aldons J. Lusis, Matteo Pellegrini   +5 more
doaj   +1 more source

Improvement of Mouse Spermatozoa Freezing at ‐80°C With Ascorbic Acid 2‐Glucoside at Thawing Phase

Andrology, EarlyView.
ABSTRACT Background Sperm cryopreservation is the most common method to maintain a great number of mutant mouse lines. However, the use of liquid nitrogen (LN2) for freezing presents considerable problems in terms of cost, safety, and accessibility. For this reason, the storage of semen samples at ‐80° in ultra‐freezers has been increasingly used in ...
Alessia Paradiso, Renata Paoletti, Simone Cassetti, Nicola Bernabò, Barbara Barboni, Marcello Raspa, Ferdinando Scavizzi   +6 more
wiley   +1 more source

Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice.

, 2019
During a screen for vascular phenotypes in aged laboratory mice, a unique discrete phenotype of hyaline arteriolosclerosis of the intertubular arteries and arterioles of the testes was identified in several inbred strains.
Alghamdi, Sarah, Silva, Kathleen A, Kennedy, Victoria E, Cooper, Timothy K, Schofield, Paul N, Sundberg, John P, Sundberg, Beth A, Hoehndorf, Robert   +7 more
core   +2 more sources

“Yet the Problem Remains”: Why Genetic Determinism Still Haunts Biomedical Research

Bioethics, EarlyView.
ABSTRACT After the horrors of the Holocaust and its connections to eugenics were revealed to the world, many post‐war population geneticists sought to establish rhetorical distance from the Nazi's state‐led campaigns, without abandoning their belief that actively shaping the population's genetics would produce a prosperous society.
Christopher R. Donohue, Ian A. Myles
wiley   +1 more source

Normal mandibular morphology of inbred mouse strains

, 2004
Indiana University-Purdue University Indianapolis (IUPUI)Even though the molecular events and pathways that underlie craniofacial development and morphogenesis are not fully understood, it is accepted that their orchestration is influenced by the ...
Edwards, Michelle Halum
core   +1 more source

Post‐Transplant Bendamustine as a Platform for Immune Modulation After Allogeneic Hematopoietic Cell Transplantation

European Journal of Haematology, EarlyView.
ABSTRACT Post‐transplant cyclophosphamide (PT‐CY) remains the standard of care for graft‐versus‐host disease (GvHD) prophylaxis in haploidentical hematopoietic cell transplantation (HCT), yet relapse, delayed immune reconstitution, infections, and organ toxicity represent persistent and clinically meaningful limitations.
Megan J. Cracchiolo, Richard J. Simpson, Emmanuel Katsanis   +2 more
wiley   +1 more source

A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2

Journal of Lipid Research, 2000
Dietary cholesterol is known to raise total and low density lipoprotein cholesterol concentrations in humans and experimental animals, but the response among individuals varies greatly.
Aram Mouzeyan, Junghee Choi, Hooman Allayee, Xuping Wang, Janet Sinsheimer, Jack Phan, Lawrence W. Castellani, Karen Reue, Aldons J. Lusis, Richard C. Davis   +9 more
doaj   +1 more source

Stress of Strains: Inbred Mice in Liver Research

Gene Expression, 2019
Inbred mice are the most popular animals used for in vivo liver research. These mice are genetically defined, readily available, less expensive to maintain than larger animals, and enjoy a broad array of commercial reagents for scientific characterization. C57BL/6 mice are the most commonly used strain. However, other strains discussed, including BALB/
openaire   +2 more sources

Shikimate pathway disruption in yeast induces metabolite self‐assembly into toxic aggregates

The FEBS Journal, EarlyView.
In Saccharomyces cerevisiae, shikimate pathway disruption induces toxic metabolite assemblies. Deleting ARO4 plus phenylalanine (Phe) feeding causes Phenylalanine accumulation, lowers ARO3 activity, and triggers amyloid‐like fibril formation. Deleting ARO3 plus tyrosine (Tyr) feeding leads to Tyrosine buildup and similar fibril assembly.
Hanaa Adsi, Myra Gartner, Claris Simovich, Lihi Gershon, Alexander Brandis, Ehud Gazit, Dana Laor Bar‐Yosef   +6 more
wiley   +1 more source

Inherent and antigen-induced airway hyperreactivity in NC mice

Allergology International, 1999
In order to clarify the airway physiology of NC mice, the following experiments were carried out. To investigate inherent airway reactivity, we compared tracheal reactivity to various chemical mediators in NC, BALB/c, C57BL/6 and A/J mice in vitro.
Tetsuto Kobayashi, Toru Miura, Tomoko Haba, Miyuki Sato, Masao Takei, Isao Serizawa   +5 more
doaj   +1 more source