Results 141 to 150 of about 259,574 (259)

Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]

, 1995
Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core   +1 more source

Resistance and Aerobic Preconditioning Delays Unloading‐Induced Multisystemic Physiological Changes: The NEBULA Project

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
This graphical abstract illustrates the NEBULA project, which examines combined high intensity preconditioning exercise as a countermeasure to microgravity. Mice underwent 3 weeks of training before 7–21 days of hindlimb unloading. After 7 days of simulated microgravity, trained mice showed positive adaptations related to the prevention of ...
Théo Fovet, Margot Issertine, Pauline Jacob, Stephanie Ghislin, Norbert Laroche, Sandrine Roffino, Claire Camy, Julian Theuil, Christelle Bertrand‐Gaday, Pierre Delobel, Béatrice Chabi, Vincent Ollendorff, Guillaume Py, Jean‐Pol Frippiat, Jean‐Luc Morel, Laurence Vico, Thomas Brioche, Maura Strigini, Angèle Chopard   +18 more
wiley   +1 more source

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

Advanced Science, Volume 12, Issue 26, July 10, 2025.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen   +18 more
wiley   +1 more source

Genetic factors at the enterocyte level account for variations inintestinal cholesterol absorption efficiency among inbred strains of mice1

Journal of Lipid Research, 2001
Interindividual and interstrain variations in cholesterol absorptionefficiency occur in humans and animals. We investigated physiological biliaryand small intestinal factors that might determine variations in cholesterolabsorption efficiency among inbred
David Q-H. Wang, Beverly Paigen, Martin C. Carey   +2 more
doaj  

AK2‐Deficient Mice Recapitulate Impaired Lymphopoiesis of Reticular Dysgenesis Patients, but Also Lack Erythropoiesis

European Journal of Immunology, Volume 55, Issue 7, July 2025.
Ak2 deficiency leads to impaired development of T and B cells in mice, corresponding to impaired lymphopoiesis of reticular dysgenesis (AK2 deficiency) in humans. In contrast to the human pathophysiology, Ak2 deficiency is lethal in mice due to severe anaemia, and murine myelopoiesis is less affected.
Rebekka Waldmann, Franziska Werner, Alpaslan Tasdogan, Felix Immanuel Maier, Ursula Kohlhofer, Irene Gonzalez‐Menendez, Leticia Quintanilla de Fend, Amrit Kaur Puarr, Ruth Maree Arkell, Anselm Enders, Manfred Hoenig, Hubert Schrezenmeier, Hans Joerg Fehling, Klaus Schwarz, Ulrich Pannicke   +14 more
wiley   +1 more source

Induced Pluripotent Stem Cells for the Treatment of Lysosomal Storage Disorders

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Lysosomal disorders (LSDs) are a group of rare metabolic disorders, with an overall incidence of 1:4800 to 1:8000 live births. LSDs are primarily caused by dysfunctional lysosomal enzymes, which typically lead to the progressive accumulation of substrates within cellular lysosomes.
Maryann Lorino, Bei Qiu, Brian Bigger
wiley   +1 more source

In Silico Approaches and the Role of Ontologies in Aging Research [PDF]

, 2013
The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means.
Busch, Hauke, Börries, Melanie, de Grey, Aubrey, Fuellen, Georg, Hahn, Udo, Hiller, Thomas, Hoeflich, Andreas, Jansen, Ludger, Janssens, Georges E., Kaleta, Christoph, Meinema, Anne C., Others, Schofield, Paul N., Schäuble, Sascha, Smith, Barry   +14 more
core  

Gluten‐free breadsticks with Ganoderma‐fermented corncobs: technological and nutritional features

Journal of the Science of Food and Agriculture, Volume 105, Issue 9, Page 4916-4926, July 2025.
Abstract Background This study investigates the use of corncobs before and after fermentation with Ganoderma annularis (G) to enhance the nutritional value of gluten‐free breadsticks. Medicinal mushrooms are known to increase the nutrient profile of substrates through solid‐state fermentation (SSF); nevertheless, using the entire SSF – as adopted in ...
Carola Cappa, Giulia Castorina, Giovanni Fiorillo, Maria Cristina Casiraghi, Manuela Rollini, Gabriella Consonni, Daniela Erba, Noemi Negrini, Alessandra Marti   +8 more
wiley   +1 more source

Strain specific behavioral and physiological responses to constant light in male CBA/J and CBA/CaJ mice

Sleep Science
Objective:: Being visually impaired increases the likelihood of sleep disorders and altered behavior. This study investigated physiological and behavioral differences in two similar mice substrains when exposed to constant light (LL) - CBA/J with retinal
Hannah V Deane, Holly A Concepcion, Avery E Gatewood, Janessa Quintana, Joseph A Seggio   +4 more
doaj   +1 more source

Phenotypic characteristics of commonly used inbred mouse strains

Journal of molecular medicine, 2020
W. Y. Tam, K. Cheung
semanticscholar   +1 more source