Results 131 to 140 of about 122,026 (216)

Characterization and Protective Efficacy of a Salmonella Typhimurium ATCC 14028 sptP Mutant as a Live Attenuated Vaccine Candidate. [PDF]

Vaccines (Basel)
Zhou N, Ding Y, He T, Sun Y, Chen H, Huang M, Li T.   +6 more
europepmc   +1 more source

Improved husbandry measures to enhance reproducibility of wound healing studies in the Leprdb/db mouse

Animal Models and Experimental Medicine, EarlyView.
Though the Leprdb/db mouse is a common and well‐studied model of type II diabetes mellitus, there are a few specific guidelines for its husbandry, and wound complications are common. We present a modified husbandry approach for the Leprdb/db mouse that includes increased cage size, decreased housing density, and more frequent cage changes.
May Barakat, Brian P. David, Junhe Shi, Angela Xu, Terry W. Moore, Lin Chen, Luisa A. DiPietro   +6 more
wiley   +1 more source

Capsular polysaccharide enables <i>Klebsiella pneumoniae</i> to evade phagocytosis by blocking host-bacteria interactions. [PDF]

mBio
Liu X, Xu Q, Yang X, Heng H, Yang C, Yang G, Peng M, Chan EW-C, Chen S.   +8 more
europepmc   +1 more source

Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges

Animal Models and Experimental Medicine, EarlyView.
Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley   +1 more source

Endogenous nitric oxide promotes <i>Staphylococcus aureus</i> virulence by activating autophagy. [PDF]

mBio
Nurxat N, Wang Q, Zhao N, Guo Y, Zhang X, Wang Y, Jian Y, Wang H, Yang S, Li M, Liu Q.   +10 more
europepmc   +1 more source

Animal models of lung cancer: Phenotypic comparison of different animal models of lung cancer and their application in the study of mechanisms

Animal Models and Experimental Medicine, EarlyView.
Grafts used to construct lung cancer animal models come from various sources, primarily cell lines, patient‐derived tumor tissues, and circulating tumor cells. Based on the sources of grafts and research objectives, lung cancer animal models can be categorized into several types: chemical‐induced models, orthotopic transplantation models, heterotopic ...
Zixuan Yang, Xianbin Zhao, Lili Tan, Pingxinyi Que, Tong Zhao, Wei Huang, Dejiao Yao, Songqi Tang   +7 more
wiley   +1 more source

Regulation of type 3 fimbria expression by RstA affects biofilm formation and virulence in <i>Klebsiella pneumoniae</i> ATCC43816. [PDF]

Microbiol Spectr
Zhang X, Zhai Y, Zhu J, Zhu Z, Wen Y, Gao Q, Wang L, Lin J, Qian Y, Chen L, Du H.   +10 more
europepmc   +1 more source

Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models

Animal Models and Experimental Medicine, EarlyView.
We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv, Ming Liu, Feifei Qi, Mingya Liu, Fengdi Li, Ran Deng, Xujian Liang, Yanfeng Xu, Zhiqi Song, Yiwei Yan, Shuyue Li, Guocui Mou, Linlin Bao   +12 more
wiley   +1 more source

The global transcriptional regulator MgaSpn affects the virulence of Streptococcus pneumoniae by regulating PcpA. [PDF]

BMC Microbiol
Wang S, Xu T, Tao Y, Lei L, Zhang X, Yin Y, Zheng Y.   +6 more
europepmc   +1 more source

Advances in CRISPR‐Cas9 in lineage tracing of model animals

Animal Models and Experimental Medicine, EarlyView.
Cell lineage tracing is a key technology for describing the developmental history of individual progenitor cells and assembling them to form a lineage development tree. However, traditional methods have limitations of poor stability and insufficient resolution.
Jingchao Cao, Zihang Guo, Xueling Xu, Pan Li, Yi Fang, Shoulong Deng   +5 more
wiley   +1 more source