Results 201 to 210 of about 256,488 (286)

A critical role of copper homeostasis in the virulence of Klebsiella pneumoniae. [PDF]

Commun Biol
Han M, Chen Q, Xu F, Zhao C, Ma X, Jin Q, Yang J, Wang Y, Qiang R, Hong D, Zhang H.   +10 more
europepmc   +1 more source

Aspergillus fumigatus copper export machinery and reactive oxygen intermediate defense counter host copper-mediated oxidative antimicrobial offense [PDF]

, 2017
Dinauer, Mary C, et al,, Idol, Rachel A
core   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Rodent models of genetic epilepsy and its association with neurocognitive impairment- a systematic review. [PDF]

Front Pharmacol
Foo RYN, Chiew IJL, Arulsamy A, Lee VLL.
europepmc   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Evolutionary Origins and Virulence Determinants of ST25 Hypervirulent <i>Klebsiella pneumoniae</i> in Swine: Genomic Insights and Functional Validation. [PDF]

Transbound Emerg Dis
Chen Z, Liu Y, Du C, Gao S, Zhai L, Schwarz S, Liu W, Li Q, Li L, Yu R, Zhao Y, Yao H, Luo L, Liu X, Xu C, Du XD.   +15 more
europepmc   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

The <i>Candida albicans</i> transcription factor Efg1 governs hyphal morphogenesis independently of the cAMP-protein kinase A pathway. [PDF]

mBio
Kramara J, Wakade RS, Frazer C, Stamnes MA, Bennett RJ, Krysan DJ.   +5 more
europepmc   +1 more source

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

Recent advances in host models in studying virulence factors and pathogenesis of <i>Acinetobacter baumannii</i>. [PDF]

Front Cell Infect Microbiol
Garomsa TL, Shenkutie AM, Leung PHM.
europepmc   +1 more source