Results 221 to 230 of about 256,488 (286)

O‑Island 28 encodes a type I secretion and RTX adhesion system regulated by RstA and required for early EHEC O157:H7 adherence. [PDF]

Gut Microbes
Niu T, Huang M, He F, Yu X, Chen A, Shi Y, Han J, Lian X, Su J, Liu Y, Ru C.   +10 more
europepmc   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Sterol-C4-methyl-oxidase Erg251 governs Candida albicans hypoxic growth, commensalism and virulence. [PDF]

Nat Commun
Liu Z, Yiu B, Basso P, Chen X, Patel D, Davie T, Hossain S, Fu C, Archambault LS, Duncan D, Wright GD, Noble SM, Robbins N, Cowen LE.   +13 more
europepmc   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Identification of the Genetic Basis of Phage Resistance in Sequentially Generated Phage-Resistant <i>Klebsiella pneumoniae</i> Using an Established Phage Library. [PDF]

Antibiotics (Basel)
Zhao W, Du C, Chen Z, Zhao Y, Schwarz S, Yao H, Li C, Xu C, Du XD.   +8 more
europepmc   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Contribution of the different Neisseria gonorrhoeae lipooligosaccharide structural variants to functional responses elicited by GMMA outer membrane vesicles. [PDF]

NPJ Vaccines
Cuffaro R, Buffi G, Romagnoli G, Giuliani M, Proietti D, Zambelli M, Spinsanti M, Manetti AGO, Fabbrini M, Savino S, Giordano G, Delany I, Bartolini E, Ram S, Romano MR, Margarit I, Carboni F.   +16 more
europepmc   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

<i>Lactiplantibacillus plantarum</i> Lp20 Alleviates High Fat Diet-Induced Obesity in Mice via Its Bile Salt Hydrolase Activity. [PDF]

Nutrients
Bai X, Lu F, Jing Y, Wang H, Qian H, Zhang M, Zhai Z, Hao Y.   +7 more
europepmc   +1 more source

NON-MIGRAINE RELATED PAIN BEHAVIOURS IN A TRANSGENIC "MIGRAINE MOUSE" WITH CIRCADIAN DISRUPTION [PDF]

, 2017
Goadsby, Peter J, Holland, Philip R, Holton, Christopher, Lopes, Douglas M, McMahon, Stephen B, Ptacek, Louis J, Strother, Lauren C   +6 more
core   +1 more source