Results 261 to 270 of about 256,488 (286)

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

Nature Genetics, 2000
Astrocytomas are the leading cause of brain cancer in humans. Because these tumours are highly infiltrative, current treatments that rely on targeting the tumour mass are often ineffective. A mouse model for astrocytoma would be a powerful tool for dissecting tumour progression and testing therapeutics. Mouse models of astrocytoma have been designed to
K M, Reilly, D A, Loisel, R T, Bronson, M E, McLaughlin, T, Jacks   +4 more
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An abnormality of hepatic lipogenesis in a mutant strain of acatalasemic mice

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973
Abstract Previous work demonstrating a relationship between acatalasemia and hypolipidemia prompted the present investigation, in which an in vitro assessment of rates of sterol and fatty acid synthesis was undertaken. A mutant strain of mice harboring the acatalasemic defect was studied, together with normal control animals and mice heterozygous ...
Cuadrado, R R, Bricker, L A
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Induction of various autoantibodies by mutant gene lpr in several strains of mice.

The Journal of Immunology, 1984
Abstract The effect of the autosomal mutant gene lpr (lymphoproliferation) on the development of various autoantibodies and immune complex (IC) glomerulonephritis was investigated in four genetically distinct strains of mice: MRL/ MpJ , C3H/HeJ, C57BL/6J, and AKR/J.
Izui, S, Kelley, V E, Masuda, K, Yoshida, H, Roths, J B, Murphy, E D   +5 more
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Systemic Infection Following Intravenous Inoculation of Mice with Candida albicans int1 Mutant Strains

Molecular Genetics and Metabolism, 1999
The Candida albicans gene INT1 is associated with epithelial adhesion, hyphal formation, and virulence. C. albicans strains carrying two, one, or no functional INT1 alleles were used to assess the association between mortality and C. albicans persistence in the liver and kidney of intravenously inoculated mice. Mice were injected with 10(5) C. albicans
C M, Bendel, K M, Kinneberg, R P, Jechorek, C A, Gale, S L, Erlandsen, M K, Hostetter, C L, Wells   +6 more
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Xenotropic virus-related restriction patterns of non-H-2 histocompatibility mutant mice strains

Immunogenetics, 1986
The relationship between alteration in the number of xenotropic virus-related sequences and non-H-2 histocompatibility (H) mutations in mice was investigated. Mutant classifications included gain, loss, and loss-gain mutations. Genomic DNA from a panel of non-H-2 H mutant strains on the C57BL/6 and BALB/c backgrounds was digested with a set of ...
P J, Wettstein, R W, Melvold
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Pentylenetetrazol‐Induced Convulsion and Effect of Anticonvulsants in Mutant Inbred Strain El Mice

Epilepsia, 1986
Summary: The El mouse is an inbred strain developed from ddY mice and is very susceptible to seizure. In El mice, convulsions could be induced by 18 mg/kg of pentylenetetrazol, which is an inert dose in ddY mice. The features of the convulsions were the same as those induced by the tossing‐up procedure, a common method to evoke convulsions in El mice.
E, Sugaya, A, Ishige, K, Sekiguchi, S, Iizuka, K, Ito, A, Sugimoto, M, Aburada, E, Hosoya   +7 more
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Early development in mice: V. Sensorimotor development of four coisogenic mutant strains

Physiology & Behavior, 1989
Effects on sensorimotor development of four genes (at, Re, fz, and Wv) involved in coat color differences were investigated by employing four coisogenic strains of mice with the same genetic background C57BL/6JOrl (B6). Compared to wild-type B6, two mutations (fz and Wv) showed pleiotropic effects on development but the direction of these effects ...
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Cerebroside and Sulphatide Deficiency in the Brain of “Jimpy Mice”, a Mutant Strain of Mice exhibiting Neurological Symptoms

Nature, 1968
THERE is a primary defect of brain lipid metabolism in several pathological conditions of the central nervous system in human and animal species.
Galli, C, Galli, D R
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Functionality of cryopreserved juvenile ovaries from mutant mice in different genetic background strains after allotransplantation

Cryobiology, 2010
The rapid expansion of mutant mouse colonies for biomedical research has resulted in lack of space at laboratory animal facilities and increasing risks of losing precious lines. These challenges require cheap and effective methods in addition to freezing embryos and sperm to archive the expanding mutant mouse lines.
Huang, K.Y., de Groot, S.A., Woelders, H., van der Horst, G.T.J., Themmen, A.P.N., Colenbrander, B., Fentener van Vlissingen, J.M.   +6 more
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Biological Methods for Archiving and Maintaining Mutant Laboratory Mice. Part I: Conserving Mutant Strains

2009
The mouse is now firmly established as the model organism of choice for scientists studying mammalian biology and human disease. Consequently, a plethora of novel, genetically altered (GA) mouse lines have been created. In addition, the output from the large scale mutagenesis programmes currently under way around the world will increase the collection ...
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