Results 71 to 80 of about 252,850 (254)

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, EarlyView.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Pathogenicity of Treponema denticola Wild-Type and Mutant Strain Tested by an Active Mode of Periodontal Infection Using Microinjection

International Journal of Dentistry, 2012
The available passive mode of periodontal infections in mice requires high efficiency of bacterial attachment and invasiveness and is not always suitable to test the pathogenicity of genetically engineered mutant strains.
Jacques Izard, Hajime Sasaki, Ralph Kent
doaj   +1 more source

Vat Polymerization 3D Printing for Controlled Drug Release Applications

Advanced Materials Technologies, EarlyView.
ABSTRACT Vat polymerization (VP) 3D printing, a light‐based additive manufacturing technique, has emerged as a promising technique for fabricating complex drug delivery systems with high precision and spatial resolution. This layer‐by‐layer manufacturing process enables the creation of intricate geometries and customizable architectures, which are ...
Hafiz Busari, O. Thompson Mefford, M. Aaron Vaughn   +2 more
wiley   +1 more source

Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence. [PDF]

, 2019
Rickettsia are obligate intracellular bacteria that evade antimicrobial autophagy in the host cell cytosol by unknown mechanisms. Other cytosolic pathogens block different steps of autophagy targeting, including the initial step of polyubiquitin-coat ...
Burke, Thomas P, Cox, Jeffery S, Engström, Patrik, Golovkine, Guillaume, Iavarone, Anthony T, Ingabire, Nadia, Mark, Kevin G, Mitchell, Gabriel, Rape, Michael, Welch, Matthew D   +9 more
core  

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains

Memorias do Instituto Oswaldo Cruz, 2008
In the present study we investigated the flagellin-specific serum (IgG) and fecal (IgA) antibody responses elicited in BALB/c mice immunized with isogenic mutant derivatives of the attenuated Salmonella enterica serovar Typhimurium (S.
LM Massis, CJM Braga, ME Sbrogio-Almeida, C Lauand, SMC Newton, PE Klebba, LCS Ferreira   +6 more
doaj   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis

mSphere, 2018
Nonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a ...
Kiranmai Bhatt, Henrique Machado, Nuno S. Osório, Jeremy Sousa, Filipa Cardoso, Carlos Magalhães, Bing Chen, Mei Chen, John Kim, Albel Singh, Catarina M. Ferreira, António G. Castro, Egidio Torrado, William R. Jacobs, Apoorva Bhatt, Margarida Saraiva   +15 more
doaj   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Testing the Cre-mediated genetic switch for the generation of conditional knock-in mice.

PLoS ONE, 2019
The Cre-mediated genetic switch combines the ability of Cre recombinase to stably invert or excise a DNA fragment depending upon the orientation of flanking mutant loxP sites.
Mattia Capulli, Rossella Costantini, Stephan Sonntag, Antonio Maurizi, Chiara Paganini, Luca Monti, Antonella Forlino, Doron Shmerling, Anna Teti, Antonio Rossi   +9 more
doaj   +1 more source