Results 251 to 260 of about 1,780,625 (304)

Characterization of MCH-mediated obesity in mice

American Journal of Physiology-Endocrinology and Metabolism, 2003
Melanin-concentrating hormone (MCH) is a cyclic orexigenic peptide expressed in the lateral hypothalamus. Recently, we demonstrated that chronic intracerebroventricular infusion of MCH induced obesity accompanied by sustained hyperphagia in mice. Here, we analyzed the mechanism of MCH-induced obesity by comparing animals fed ad libitum with pair-fed ...
Masahiko, Ito, Akira, Gomori, Akane, Ishihara, Zenjun, Oda, Satoshi, Mashiko, Hiroko, Matsushita, Mariko, Yumoto, Makoto, Ito, Hideki, Sano, Shigeru, Tokita, Minoru, Moriya, Hisashi, Iwaasa, Akio, Kanatani   +12 more
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Cholesterol metabolism in obese mice

Canadian Journal of Biochemistry, 1980
Young male obese mice and their lean litter mates (strain ob/ob) were compared. Serum cholesterol levels were higher in obese than in lean animals. 3-Hydroxy-3-methylglutaryl-CoA reductase activity was lower in brown adipose tissue and liver of obese mice than in tissue from their lean litter mates. However, activity of this enzyme was found to be the
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Diabetes-Obesity Syndromes in Mice

Diabetes, 1982
Several different rodent models are available for metabolic studies on the development of diabetes. Although the abnormalities associated with each diabetes type have many features in common, the documentation of several different genes being involved makes it unlikely that the various syndromes will be reduced to a single disturbance in one metabolic ...
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A Virally Induced Obesity Syndrome in Mice

Science, 1982
An obesity syndrome was found in a number of mice infected as young adults with canine distemper virus, a morbillivirus antigenically related to measles. Body weights of obese animals 16 to 20 weeks after infection were comparable to those reported for genetically obese mice and for mice rendered obese by hypothalamic lesions.
M J, Lyons, I M, Faust, R B, Hemmes, D R, Buskirk, J, Hirsch, J B, Zabriskie   +5 more
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Levels of Serum Cholesterol in Obese Mice

Nature, 1958
CHOLESTEROL-levels have been the object of considerable attention lately because of their possible relation to degenerative diseases, atherosclerosis in particular. In a number of experiments hyper-cholesterolaemia has been produced in experimental animals by adding cholesterol to the diet and by making other dietary changes.
C, ZOMZELY, J, MAYER
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Brain myelin of genetically obese mice

Journal of the Neurological Sciences, 1985
Brain myelin was studied in genetically obese (ob/ob) mice and compared with that of normal (+/+) mice from the same strain. The brain from obese mice had a significantly lower amount of myelin, and marked changes in the fatty acid composition of myelin were observed.
A, Sena, L L, Sarliève, G, Rebel
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Cholecystokinin in the Brains of Obese and Nonobese Mice

Science, 1979
Extracts of the cerebral cortex of genetically obese ( ob / ob ) mice with hyperphagia contain 0.05 ± 0.02 microgram (mean ± standard error) of cholecystokinin octapeptide equivalent per gram of wet weight compared to 0.15 ± 0.01 microgram per gram for their nonobese littermates and 0.20 ± 0 ...
Straus, E, Yalow, R S
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Taste loss with obesity in mice and men

International Journal of Obesity, 2019
Our sense of taste is critical in defining our food choices and habits. Located primarily in our tongue, taste buds are small assemblies of constantly renewing sensory cells, tasked with evaluating oral stimuli before the food we eat is consumed.Using both mice and a free-living human population, we tracked taste papilla abundancy with weight gain, to ...
Andrew Kaufman, Jennie Kim, Corinna Noel, Robin Dando   +3 more
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Gastrointestinal apudosis in obese hyperglycaemic mice

Virchows Archiv B Cell Pathology, 1975
Quantitative histological and immunocytochemical studies have been carried out on the endocrine cells of the gastrointestinal tract in genetically obese mice and their heterozygous (lean) litter mates. In the ob/ob mice hyperplasia of most of the endocrine (APUD) cells of the gut was found, a condition which can be described as apudosis.
J M, Polak, A G, Pearse, L, Grimelius, V, Marks   +3 more
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Hyperinsulinism in Mice with Genetically Determined Obesity

Endocrinology, 1969
Blood glucose, plasma insulin and pancreatic insulin content in obese mice (obob) have been measured at various ages and compared to results from normal mice. Plasma insulin of obese mice was 8- to 30-fold higher than controls at all ages and irrespective of concurrent hyperglycemia.
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