Results 261 to 270 of about 240,716 (309)

Fatty Acid Mobilization in Obese Mice

Nature, 1970
PREPARATIONS of adipose tissue from obese hyperglycaemic mice of the C57B1/6J-ob strain have a reduced sensitivity to the fatty acid mobilizing activity of epinephrine1. Epinephrine is believed to exert its lipolytic effect by increasing the production of cyclic AMP2. This activates
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Mitochondrial proton leak in obesity-resistant and obesity-prone mice

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2007
We quantified uncoupling proteins (UCPs) in molar amounts and assessed proton conductance in mitochondria isolated from interscapular brown adipose tissue (IBAT) and hindlimb muscle [known from prior work to contain ectopic brown adipose tissue (BAT) interspersed between muscle fibers] of obesity-resistant 129S6/SvEvTac (129) and obesity-prone C57BL/6
Brian D, Fink, Judy A, Herlein, Katrine, Almind, Saverio, Cinti, C Ronald, Kahn, William I, Sivitz   +5 more
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Regulation of obese gene expression in KK mice and congenic lethal yellow obese KKAy mice

American Journal of Physiology-Endocrinology and Metabolism, 1996
To elucidate the regulation of obese (ob) gene expression in obesity and diabetes, we examined ob gene expression in KK mice and congenic lethal yellow obese KKAy mice. Northern blot analysis revealed that the ob mRNA levels are roughly equivalent in each of the epididymal, mesenteric, and subcutaneous white adipose tissue (WAT) from KK and KKAy mice ...
M, Hayase, Y, Ogawa, G, Katsuura, H, Shintaku, K, Hosoda, K, Nakao   +5 more
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CASTRATION-INDUCED OBESITY IN MICE.

Acta Endocrinologica, 1966
ABSTRACT Body composition and histology of the adrenal cortex and the islets of Langerhans were compared in yellow-obese mice, their intact non-obese littermates and their castrated, originally non-obese littermates. In our colony, yellow females were heavier and fatter than males. Obesity developed in yellow mice of both sexes which were fed a
Franz X. Hausberger, Brigitte C. Hausberger   +1 more
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Wound Collagen Accumulation in Obese Hyperglycemic Mice

Diabetes, 1986
We used C57-BL ob/ob mice as a model to study wound healing in type II (adult-onset) diabetes. Planimetry was used to assess rate of closure in standard open skin wounds. In agreement with previous subcutaneous wound collagen-accumulation studies, closure was slower in the ob/ob mice.
W H, Goodson, T K, Hunt
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β-Cell Function in Obese-Hyperglycemic Mice (ob /ob Mice)

2010
This review summarizes key aspects of what has been learned about the physiology of pancreatic islets and leptin deficiency from studies in obese ob/ob mice. ob/ob Mice lack functional leptin. They are grossly overweight and hyperphagic particularly at young ages and develop severe insulin resistance with hyperglycemia and hyperinsulinemia.
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Obese Mutant Mice: Obese (ob) and Diabetes (db)

1989
Obese (ob/ob) and diabetes (db/db) mutant mice are phenotypically identical both being severely obese, adults weighing from 45–60 g compared with 25–30 g for normal littermates. Most of the excess body weight represents large stores of white adipose tissue located in the axial and inguinal regions.
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Obesity in Mice and Men

Obesity Research, 2001
B R, Bistrian, K C, McCowen
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Scrapie-Induced Obesity in Mice

Journal of Infectious Diseases, 1987
Y S, Kim, R I, Carp, S M, Callahan, H M, Wisniewski   +3 more
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Obesity Genes: Beneficial Effects in Heterozygous Mice

Science, 1979
The mouse mutant genes obese ( ob ) and diabetes ( db ) cause similar obesity-diabetes states in homozygotes. These obesity syndromes are characterized by a more efficient conversion of food to lipid and, once stored, a slower rate of catabolism on fasting. Heterozygous mice, either
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