Results 261 to 270 of about 241,974 (292)
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Cholesterol metabolism in obese mice
Canadian Journal of Biochemistry, 1980Young male obese mice and their lean litter mates (strain ob/ob) were compared. Serum cholesterol levels were higher in obese than in lean animals. 3-Hydroxy-3-methylglutaryl-CoA reductase activity was lower in brown adipose tissue and liver of obese mice than in tissue from their lean litter mates. However, activity of this enzyme was found to be the
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Diabetes-Obesity Syndromes in Mice
Diabetes, 1982Several different rodent models are available for metabolic studies on the development of diabetes. Although the abnormalities associated with each diabetes type have many features in common, the documentation of several different genes being involved makes it unlikely that the various syndromes will be reduced to a single disturbance in one metabolic ...
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Biological Trace Element Research, 1996
A perturbation of zinc metabolism has been noted in numerous laboratory animals with diabetes and obesity. The effects of zinc supplementation on body fat deposition in two types of experimental obese mice: genetically obese (ob/ob) mice and high-fat diet-induced ICR obese (HF) mice were investigated in this study. Their lean controls were +/?
M D, Chen, P Y, Lin, V, Cheng, W H, Lin
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A perturbation of zinc metabolism has been noted in numerous laboratory animals with diabetes and obesity. The effects of zinc supplementation on body fat deposition in two types of experimental obese mice: genetically obese (ob/ob) mice and high-fat diet-induced ICR obese (HF) mice were investigated in this study. Their lean controls were +/?
M D, Chen, P Y, Lin, V, Cheng, W H, Lin
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Fatty Acid Mobilization in Obese Mice
Nature, 1970PREPARATIONS of adipose tissue from obese hyperglycaemic mice of the C57B1/6J-ob strain have a reduced sensitivity to the fatty acid mobilizing activity of epinephrine1. Epinephrine is believed to exert its lipolytic effect by increasing the production of cyclic AMP2. This activates
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Mitochondrial proton leak in obesity-resistant and obesity-prone mice
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2007We quantified uncoupling proteins (UCPs) in molar amounts and assessed proton conductance in mitochondria isolated from interscapular brown adipose tissue (IBAT) and hindlimb muscle [known from prior work to contain ectopic brown adipose tissue (BAT) interspersed between muscle fibers] of obesity-resistant 129S6/SvEvTac (129) and obesity-prone C57BL/6
Brian D, Fink +5 more
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Regulation of obese gene expression in KK mice and congenic lethal yellow obese KKAy mice
American Journal of Physiology-Endocrinology and Metabolism, 1996To elucidate the regulation of obese (ob) gene expression in obesity and diabetes, we examined ob gene expression in KK mice and congenic lethal yellow obese KKAy mice. Northern blot analysis revealed that the ob mRNA levels are roughly equivalent in each of the epididymal, mesenteric, and subcutaneous white adipose tissue (WAT) from KK and KKAy mice ...
M, Hayase +5 more
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CASTRATION-INDUCED OBESITY IN MICE.
Acta Endocrinologica, 1966ABSTRACT Body composition and histology of the adrenal cortex and the islets of Langerhans were compared in yellow-obese mice, their intact non-obese littermates and their castrated, originally non-obese littermates. In our colony, yellow females were heavier and fatter than males. Obesity developed in yellow mice of both sexes which were fed a
Franz X. Hausberger +1 more
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Wound Collagen Accumulation in Obese Hyperglycemic Mice
Diabetes, 1986We used C57-BL ob/ob mice as a model to study wound healing in type II (adult-onset) diabetes. Planimetry was used to assess rate of closure in standard open skin wounds. In agreement with previous subcutaneous wound collagen-accumulation studies, closure was slower in the ob/ob mice.
W H, Goodson, T K, Hunt
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β-Cell Function in Obese-Hyperglycemic Mice (ob /ob Mice)
2010This review summarizes key aspects of what has been learned about the physiology of pancreatic islets and leptin deficiency from studies in obese ob/ob mice. ob/ob Mice lack functional leptin. They are grossly overweight and hyperphagic particularly at young ages and develop severe insulin resistance with hyperglycemia and hyperinsulinemia.
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Obese Mutant Mice: Obese (ob) and Diabetes (db)
1989Obese (ob/ob) and diabetes (db/db) mutant mice are phenotypically identical both being severely obese, adults weighing from 45–60 g compared with 25–30 g for normal littermates. Most of the excess body weight represents large stores of white adipose tissue located in the axial and inguinal regions.
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