Results 131 to 140 of about 70,603 (247)

Targeting the NAT1‐ENO1‐Lactate Axis Destabilizes PD‐L1 to Reinvigorate Antitumor Immunity in Colorectal Cancer

MedComm, Volume 7, Issue 8, August 2026.
NAT1 downregulates PD‐L1 protein expression by acetylating ENO1, which inhibits lactate‐fueled TRAF6/PD‐L1 signaling (left). Conversely, NAT1 deficiency in CRC cells enhances ENO1 activation, leading to increased glycolysis and lactate production. The lactate then binds to TRAF6, promoting its oligomerization and activation.
Yi‐Xuan Liu, Wen‐Xin Wu, Yang Zang, Guang Hu, Xin Guo, Yi Wang, Yun Yang, Zhi Jiang, Xiu‐Ming Li, Feng Liu, Yue‐Yue Wu, Zu‐Da Pan, Yuan‐Meng Hu, Ruo‐Yang Zhang, Hai‐Yi Zhang, Ping‐An Chang, Xiao‐Shun He, Wen‐Juan Gan, Hua Wu   +18 more
wiley   +1 more source

Repurposing Hetrombopag for Multiple Myeloma by Targeting PNPO: A Celastrol-Inspired Approach. [PDF]

Basic Clin Pharmacol Toxicol
Yu T, Wang C, Xie J, Wei Y, Cui H, Zhang H, Zhou F, Deng Z, Yang Y, Gu C.   +9 more
europepmc   +1 more source

A single‐view‐based electroacoustic tomography imaging using deep learning for electroporation monitoring

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Electroacoustic tomography (EAT) is an emerging imaging technique with potential for guiding electroporation therapy. However, in clinical applications, EAT scan is typically limited to a single view acquisition, leading to severe artifacts in the reconstruction.
Jie Zhang, Yifei Xu, Leshan Sun, Yankun Lang, Liangzhong Xiang, Lei Ren   +5 more
wiley   +1 more source

Tracing the in vivo behavior of nucleated cultured red blood cells generated from hematopoietic stem and progenitor cells. [PDF]

Stem Cell Res Ther
Xu L, Yang Z, Liang L, Zhang J, Yuan X, Liu P, Dong Q, Pei X, Qu M, Yue W, Xie X.   +10 more
europepmc   +1 more source

Insights Into Genomic Drivers, Transcriptomic Heterogeneity, and Therapeutic Vulnerabilities From Novel Mesothelioma Cell Lines

Thoracic Cancer, Volume 17, Issue 15, August 2026.
Three novel malignant pleural mesothelioma (MPM) cell lines (PUMC‐MESO1, PUMC‐MESO3, and PUMC‐MESO4) were established from patient‐derived pleural effusions. All three cell lines expressed mesothelioma markers (calretinin, WT1, and D2‐40) and showed BAP1 loss of expression.
Yani Wu, Fang Cao, Jiayin Dai, Zhenli Yang, Yanli Zhu, Dongmei Lin, Xiaocui Bian, Yuqin Liu   +7 more
wiley   +1 more source

Immunity beyond borders: non-lethal <i>Plasmodium</i> confers cross-protection against lethal <i>Babesia</i> via macrophage activation. [PDF]

Front Immunol
Zafar I, Li Y, Kondoh D, El-Sayed SAE, Hasan T, Taniguchi T, Li H, Inoue N, Kato K, Xuan X.   +9 more
europepmc   +1 more source

Construction and characterization of novel <i>Mycobacterium tuberculosis</i>-derived triple and quadruple knockout vaccines against tuberculosis. [PDF]

Infect Immun
Garnica O, Veerapandian R, Das K, Mishra A, Rawat V, Carmona A, Chauhan V, Kumar R, Chacon J, Khan A, Ramos EI, Gadad SS, Jagannath C, Dhandayuthapani S.   +13 more
europepmc   +1 more source

The Natural Quassinoid Brusatol Enhances Venetoclax Efficacy and Overcomes Resistance in Myeloid Leukemias

Cancer Science, Volume 117, Issue 8, Page 2274-2288, August 2026.
Schematic illustration of the mechanisms by which the natural quassinoid brusatol induces apoptosis in myeloid leukemias and enhances venetoclax efficacy via p53‐dependent apoptosis and mitochondrial dysfunction. ABSTRACT While venetoclax‐based combinations have shown promising results in acute myeloid leukemia (AML), the remission duration is ...
Shin‐ichiro Kawaguchi, Kazuya Sato, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Ken Suzaki, Susumu Goyama, Chiyoko Kato, Eiji Sakashita, Kaoru Tominaga, Hitoshi Endo, Yoshinobu Kanda   +11 more
wiley   +1 more source

Arctigenin Suppresses Breast Cancer Growth In Vitro and In Vivo Through Subtype-Specific Multi-Targeting Activity. [PDF]

Int J Mol Sci
Yang J, Hao Q, Wu K, Elshimali Y, Andalibi A, Wang P.   +5 more
europepmc   +1 more source

Human Pharmacokinetic Prediction of Antibody‐Drug Conjugates Using Human FcRn Transgenic Mice

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) have progressed significantly in recent years, particularly in the oncology field. However, predicting human pharmacokinetics (PK) of ADCs in the early stages of drug development remains challenging. Human neonatal Fc receptor (FcRn) transgenic mice have been established as a reliable pre‐clinical PK model for ...
Keitaro Nakagawa, Kenta Haraya
wiley   +1 more source