Results 141 to 150 of about 70,603 (247)

TFF1-mediated suppression of the TCA cycle promotes bone metastasis in triple-negative breast cancer. [PDF]

Transl Oncol
Chen H, Xu Y, Liu Y, Tang Y, Qiu J, Lei L, Lin P, Chen Y, Wu X.   +8 more
europepmc   +1 more source

Development of Chimeric Antigen Receptor‐Modified NK Cells for the Immunotherapy of Adult T‐Cell Leukemia/Lymphoma

European Journal of Haematology, Volume 117, Issue 2, Page 481-491, August 2026.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy with a poor prognosis and limited therapeutic options. ATL cells exhibit aberrant surface glycosylation patterns resulting from dysregulated glycosyltransferase expression, representing a potentially tumor‐specific therapeutic target.
Yuichiro Uchida, Seigo Tateo, Masahiro Wakao, Hiroyuki Shinchi, Hayate Sawayama, Akira Fukumoto, Makoto Yoshimitsu, Yasuo Suda   +7 more
wiley   +1 more source

Obesity Accelerates Multiple Myeloma Progression in Certain Mouse Models and in Humans. [PDF]

Cancer Prev Res (Phila)
Fairfield H, Marinac CR, Hamidi H, Knox K, Nestor B, Marques-Mourlet C, Diaz G, Wong CV, Mishra AK, Schimelman A, Qiang YW, Karam M, Farrell M, Jachimowicz E, Stohn JP, Birmann BM, Cornelius P, Reagan MR.   +17 more
europepmc   +1 more source

Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment

Immunology &Cell Biology, Volume 104, Issue 7, Page 711-728, August 2026.
Three interconnected processes in glioblastoma (GBM) biology: initiation, stratification, and immunosuppression. 1) Initiation: GBM initiation is proposed to occur through migration of TERT mutation‐bearing neural stem cells from the subventricular zone to the frontal and temporal cortices, where a subsequent oncogenic transformation drives their ...
Emerson Achari, Farah Ahmady‐Nield, Amit Sharma, Ingo G. H. Schmidt‐Wolf, Jarek Maciaczyk, Rodney B. Luwor, Adrian A. Achuthan   +6 more
wiley   +1 more source

Lipopolysaccharide suppresses lung metastasis by activating CD8⁺ T cells despite promoting effect via cancer-associated fibroblasts. [PDF]

BMC Cancer
Cui W, Li Y, Hu M, Zhang TT, Wang Z, Deng J, Wang T.   +6 more
europepmc   +1 more source

The Structure of Vertebrate Antigen Receptor Repertoires: An Evolutionary Perspective

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT In vertebrate adaptive immune systems, somatically diversified antigen receptors assume a central role in self/nonself discrimination. Attesting to the presence of a unique but unknown selective environment at early stages of vertebrate evolution, this facility emerged twice, in the ancestors of jawless and jawed vertebrates.
Thomas Boehm, Orlando B. Giorgetti
wiley   +1 more source

Intervention timing and disease stage shape tecovirimat and cidofovir efficacy in male SCID mice. [PDF]

Nat Commun
Cao X, Shi N, Qiu X, Tian J, Wang P, Liu B, Ha Z, Zhang H, Shang C, Li X, Xie Y, Shu Y, Lu H.   +12 more
europepmc   +1 more source

Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen‐Driven Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Citrullination and deamidation are post‐translational modifications (PTMs) increasingly recognized as important contributors to neoepitope formation in type 1 diabetes (T1D). Under inflammatory and endoplasmic reticulum stress conditions, beta cells activate calcium‐dependent peptidylarginine deiminase and transglutaminase enzymes, leading to ...
Aïsha Callebaut, Ylke Bruggeman, Chantal Mathieu, Eddie A. James, Lut Overbergh   +4 more
wiley   +1 more source

Advancements in Nanomedicine for Precision Management of Lymphoma: Mechanisms, Diagnostics, and Therapeutic Strategies. [PDF]

Int J Nanomedicine
Wang R, Zhang Z, Wang Q, Gu P, Yang Y, Wang B, Teng Y.   +6 more
europepmc   +1 more source

Dendritic cell‐specific hypoxia‐inducible factor‐1α deficiency protects mice from recurrent retroviral infection

Experimental Physiology, Volume 111, Issue 8, Page 3843-3856, 1 August 2026.
Abstract Antigen‐processing and ‐presenting cells play a pivotal role in initiation of the antiviral immune response. The cellular adaption of dendritic cells to reduced oxygen and nutrition levels at the site of infection is regulated predominantly by the transcription factor complex hypoxia‐inducible factor‐1 (HIF‐1).
Timm Schreiber, Yvonne Hüsecken, Claudia Lodewick, Simone Schimmer, Gennadiy Zelinskyy, Ulf Dittmer, Kathrin Sutter, Joachim Fandrey, Sandra Winning   +8 more
wiley   +1 more source