Results 201 to 210 of about 70,603 (247)

T Cell Leakiness in Scid Mice

1989
FACS analysis showed that the incidence of leaky T cells increases with age, such that virtually all old scid mice (greater than 1 year) contain detectable CD3+ cells. The number of detectable T cells remained very low; individual old scid mice generally contained less than 10(5) CD3+ cells.
A M, Carroll, R R, Hardy, J, Petrini, M J, Bosma   +3 more
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Defective repair of radiation-induced chromosomal damage in scid/scid mice

Cytogenetics and Cell Genetics, 2008
The murine severe combined immunodeficiency (scid) mutation interferes with normal recombination of iramunoglobulin and T-cell receptor genes. This immunologic defect results in a lack of fully differentiated B and T cells in scid/scid mice. Animals homozygous for the scid mutation also display increased sensitivity to the damaging effects of ionizing ...
Disney, J E, Barth, A L, Shultz, L D
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Human Hematopoiesis in SCID Mice

1995
The hematopoietic system is organized as a hierarchy where the majority of the cells are mature, and therefore, need to be continuously replenished from a small pool of immature progenitors. Ultimately, the entire hematopoietic system is derived from stem cells that have extensive proliferative and differentiation capacity and give rise to all myeloid ...
Josef Vormoor, Tsvee Lapidot, André Larochelle, John E. Dick   +3 more
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Engraftment of chronic myeloid leukemia in SCID mice

Hematological Oncology, 1998
Chronic myeloid leukemia (CML) is a clonal disorder of primitive hematopoietic stem cells characterized by a reciprocal translocation between chromosomes 9 and 22. Animal models of CML would be useful to study the biology and potential therapies in this disease.
C F, Hoyle, R S, Negrin
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Growth of Human Lymphoma Cells in SCID Mice

Leukemia & Lymphoma, 1992
Two EBV-negative human lymphoma cell lines raised in this laboratory and peripheral blood cells of a patient with large cell lymphoma in leukemic phase were injected intravenously or intraperitoneally into C.B.17 SCID mice. One line (OCI-LY18) was derived from the pleural fluid of a patient with a large cell, immunoblastic malignant lymphoma.
H, Chang, S, Leeder, V A, Cook, B, Patterson, M, Dosch, M D, Minden, H A, Messner   +6 more
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SCID mice as immune system models

Current Opinion in Immunology, 1991
C.B-17 scid/scid mice are born with severe combined immunodeficiency. This defect in the maturation of T and B cells has provided a novel experimental system in which to study normal lymphoid differentiation and function in mouse and man.
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Mucosal and disseminated candidiasis in gnotobiotic SCID mice

Medical Mycology, 1993
The alimentary tracts of germ-free SCID (severe combined immunodeficient) mice were susceptible to colonization with Candida albicans. Large viable populations (10(6)-10(8) colony forming units g-1) of C. albicans, in pure culture, were present in all sections of the intestinal tract.
E, Balish, J, Jensen, T, Warner, J, Brekke, B, Leonard   +4 more
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Enteroviral and Immune Mediated Myocarditis in SCID mice

Herz, 2000
Severe combined immune deficiency (SCID) mice have been used as an animal model to study both the direct cytopathic effect of enteroviruses on the heart in the absence of an effective immune system and to investigate the role of immune mediated processes in the pathogenesis of human myocarditis.
P L, Schwimmbeck, G, Rohn, A, Wrusch, K, Schulze, A, Doerner, U, Kuehl, C, Tschoepe, M, Pauschinger, H P, Schultheiss   +8 more
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Construction of Human‐SCID Chimeric Mice

Current Protocols in Immunology, 1998
AbstractUntil recently, testing of new therapeutic agents has relied extensively upon the use of mice and nonhuman primates for in vivo preclinical studies. Unfortunately, these animal models do not always mimic the physiological and pathophysiological processes that occur in humans.
Maria Grazia, Roncarolo, José M, Carballido   +1 more
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Transfer of Diabetes from Prediabetic NOD Mice to NOD-SCID/SCID Mice: Association with Pancreatic Insulin Content

Hormone and Metabolic Research, 2005
Splenocytes from prediabetic female NOD mice can transfer diabetes to NOD-SCID mice. Whereas the kinetics of disease transfer was shown to be a function of the age of donor splenocytes, information is scarce as to how the stage of autoimmune disease, as evaluated by pancreatic insulin content, is related to the diabetogenic potency of splenic T-cells ...
M, Füchtenbusch, E, Larger, K, Thebault, C, Boitard   +3 more
openaire   +2 more sources