Results 211 to 220 of about 70,603 (247)

Branhamella catarrhalispathogenesis in SCID and SCID/beige mice

APMIS, 1993
SCID and SCID/beige mice were used to study the pathogenesis of B. catarrhalis administered by intranasal, intraperitoneal or intravenous routes. Challenged adult animals did not appear overtly clinically ill. Similar symptoms were observed regardless of the challenge route, and pretreatment of mice with human transferrin did not enhance clinical ...
ROBIN E. HARKNESS, MARIE-JOSÉE GUIMOND, BETTY-ANNE McBEY, MICHEL H. KLEIN, DEAN H. PERCY, B. ANNE CROY   +5 more
openaire   +1 more source

Islet-Infiltrating Lymphocytes from Prediabetic NOD Mice Rapidly Transfer Diabetes to NOD-scid/scid mice

Diabetes, 1995
In an effort to study the development of diabetes in NOD mice, our laboratory developed a novel adoptive transfer model using NOD-scid/scid (NOD-scid) mice as recipients of islet-infiltrating lymphocytes from donor prediabetic female NOD mice. We first confirmed previous results that demonstrated that splenocytes of diabetic and prediabetic female NOD ...
Rohane, P W, Shimada, A, Kim, D T, Edwards, C T, Charlton, B, Shultz, L D, Fathman, C G   +6 more
openaire   +2 more sources

Spontaneous and experimental infections in scid and scid/beige mice.

Laboratory animal science, 1993
Severe combined immunodeficient (scid) mice are valuable animals to study a variety of physiologic and disease processes. Their capacity to support multiple tissue xenografts permits these mice to be used as intermediate models for host-specific, fastidious organisms for which a small animal model has not been available previously.
D H, Percy, J R, Barta
openaire   +1 more source

Viral pathogenesis in hu-PBL-SCID mice

Seminars in Immunology, 1996
The transplantation of human cells into immunodeficient mice has provided new models for human immune function, infection by pathogenic viruses that grow in lymphocytes or other hematopoietic cells, and development of hematopoietic lineages. SCID mice reconstituted with adult peripheral blood mononuclear cells (hu-PBL-SCID mice) maintain some ...
openaire   +2 more sources

An Orthotopic Model for Human Uveal Melanoma in SCID Mice

Microvascular Research, 2002
The microcirculation of primary uveal melanomas, their precursors, and their metastases is distinctive. Medium-sized and even large primary uveal melanomas typically lack significant zones of necrosis, suggesting that either these tumors are relatively well perfused or they are capable of growth in a severely blood-deprived microenvironment.
Mueller, Arthur J., Maniotis, Andrew J., Freeman, William R., Bartsch, Dirk-Uwe, Schaller, Ulrich C., Bergeron-Lynn, Germaine, Cheng, Lingyun, Taskintuna, Ibrahim, Chen, Xue, Kan-Mitchell, June, Folberg, Robert   +10 more
openaire   +2 more sources

[Histological and cytofluorometric investigations of immunodeficient CB17 scid/scid mice].

Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1992
Blood cell differentiation and development is under the control of a number of genes, and mutations in one of these genes could result in an immunodefective phenotype. Mice of the CB17 scid/scid ("severe combined imunodeficient") strain are characterized by a mutation which affects early lymphoid differentiation and lack functional T and B lymphocytes.
C H, Ladel, U, Bamberger, H, Püschner
openaire   +1 more source

Of scid mice and men

Journal of Clinical Endocrinology & Metabolism, 1993
openaire   +1 more source

Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 1994
SCID and SCID/beige mice were used to study the pathogenesis of B. catarrhalis administered by intranasal, intraperitoneal or intravenous routes. Challenged adult animals did not appear overtly clinically ill. Similar symptoms were observed regardless of the challenge route, and pretreatment of mice with human transferrin did not enhance clinical ...
R E, Harkness, M J, Guimond, B A, McBey, M H, Klein, D H, Percy, B A, Croy   +5 more
openaire   +1 more source

Spontaneous nonthymic tumors in SCID mice.

Comparative medicine, 2012
SCID mice provide an excellent platform for cancer research. Because of their lack of immunity, SCID mice readily succumb to infectious pathogens and therefore must be maintained in an SPF, barrier-protected environment. Although SPF and barrier facilities prevent infection, SCID mice remain prone to premature death due in part to a high prevalence of ...
Peigen, Huang, Susan V, Westmoreland, Rakesh K, Jain, Dai, Fukumura   +3 more
openaire   +1 more source

Implementation of SCID Screening in Denmark

International Journal of Neonatal Screening, 2021
David Michael Hougaard, Marie Bækvad-Hansen, Jonas Bybjerg-Grauholm   +2 more
exaly