Results 211 to 220 of about 120,729 (267)

Ikeda H, Hideshima T, Fulciniti M, et al. PI3K/p110δ is a novel therapeutic target in multiple myeloma. Blood 2010;116(9):1460-1468.

Blood
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Immune Deficiency in SCID Mice

International Reviews of Immunology, 1996
Since the discovery of SCID mice in 1983, numerous studies utilizing these mice were carried out. These investigations can be classified into two major groups. First, the analysis of the immune defect has revealed defective V(D)J recombination and defective DNA double-strand break repair, and has lead to the identification of the candidate gene for ...
S, Nonoyama, H D, Ochs
openaire   +2 more sources

Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice.

The American journal of pathology, 1995
T and B lymphocyte-deficient mice homozygous for the severe combined immunodeficiency (SCID) mutation can be immunologically engrafted with human lymphocytes. However, low levels of human peripheral blood mononuclear cell engraftment are commonly observed, impeding full use of this model. We now demonstrate that strain background in mice homozygous for
D L, Greiner, L D, Shultz, J, Yates, M C, Appel, G, Perdrizet, R M, Hesselton, I, Schweitzer, W G, Beamer, K L, Shultz, S C, Pelsue   +9 more
openaire   +2 more sources

Pneumocystis carinii Pneumonia in scid/scid Mice

1989
Mice homozygous for the autosomal recessive mutation severe combined immune deficiency (scid) on Chromosome 16 have proved to be a unique resource in many areas of biomedical research. Since the original report that hdmozygosity for scid causes a severe deficiency in numbers of functional T and B cells accompanied by a lack of both humoral and cell ...
Shultz, L D, Schweitzer, P A, Hall, E J, Sundberg, J P, Taylor, S, Walzer, P D   +5 more
openaire   +2 more sources

Human hematolymphoid cells in SCID mice

Current Opinion in Immunology, 1994
The severe combined immunodeficient C.B.-17 scid/scid (SCID) mouse has been widely used to study the normal processes of murine lymphoid differentiation. To create an in vivo model of the human hematolymphoid system, this mouse strain has been engrafted with human organ systems (the SCID-hu mouse) or with human peripheral blood mononuclear cells (the ...
H, Kaneshima, R, Namikawa, J M, McCune
openaire   +2 more sources

Scid Mice in Reproductive Biology

1989
Immunodeficient mice of genotype scid/scid have been used to test two major theories relating immunology to reproduction. The first idea is that fetuses express antigens foreign to the mother and may be aborted by a process analogous to classical allograft rejection, particularly when there is subnormal maternal suppressor cell activity at the ...
D A, Clark, D K, Banwatt, J, Manuel, G, Fulop, B A, Croy   +4 more
openaire   +2 more sources

Humanized SCID Mice Models of SLE

Current Pharmaceutical Design, 2011
The pathological DNA-specific B cells in Systemic lupus erythematosus are a logical target for a selected therapeutic intervention. It has been recently shown that complement receptor type 1 on human B and T-lymphocytes has suppressive activity.
Nikola, Kerekov, Nikolina, Mihaylova, Jozsef, Prechl, Andrey, Tchorbanov   +3 more
openaire   +2 more sources

Spontaneous Abortion in Immunodeficient SCID Mice

American Journal of Reproductive Immunology, 1994
PROBLEM: Immunodeficient SCID mice on the CB‐17 have been used to test the role of “rejection” in a xenogeneic blastocyst transfer model of recurrent miscarriage, but interpretation of the data requires knowing syngeneic within‐species matings have a high success rate and do not require immunotrophic factors expected only in immunocompetent non‐T‐cell ...
D A, Clark, C, Quarrington, D, Banwatt, J, Manuel, G, Fulop   +4 more
openaire   +2 more sources

Islet-Infiltrating Lymphocytes from Prediabetic NOD Mice Rapidly Transfer Diabetes to NOD-scid/scid mice

Diabetes, 1995
In an effort to study the development of diabetes in NOD mice, our laboratory developed a novel adoptive transfer model using NOD-scid/scid (NOD-scid) mice as recipients of islet-infiltrating lymphocytes from donor prediabetic female NOD mice. We first confirmed previous results that demonstrated that splenocytes of diabetic and prediabetic female NOD ...
Rohane, P W, Shimada, A, Kim, D T, Edwards, C T, Charlton, B, Shultz, L D, Fathman, C G   +6 more
openaire   +2 more sources

T Cell Leakiness in Scid Mice

1989
FACS analysis showed that the incidence of leaky T cells increases with age, such that virtually all old scid mice (greater than 1 year) contain detectable CD3+ cells. The number of detectable T cells remained very low; individual old scid mice generally contained less than 10(5) CD3+ cells.
A M, Carroll, R R, Hardy, J, Petrini, M J, Bosma   +3 more
openaire   +2 more sources