Results 1 to 10 of about 252,850 (254)

Virulence Reduction in Yersinia pestis by Combining Delayed Attenuation with Plasmid Curing [PDF]

Biomolecules
Yersinia pestis caused the three plague pandemics that claimed more than two hundred million human lives. There is still no vaccine that meets all WHO requirements, and many researchers continue to develop plague vaccines using various technological ...
Svetlana V. Dentovskaya, Rima Z. Shaikhutdinova, Mikhail E. Platonov, Nadezhda A. Lipatnikova, Elizaveta M. Mazurina, Tat’yana V. Gapel’chenkova, Pavel Kh. Kopylov, Sergei A. Ivanov, Alexandra S. Trunyakova, Anastasia S. Vagaiskaya, Andrey P. Anisimov   +10 more
doaj   +2 more sources

Pneumococcal Gene Complex Involved in Resistance to Extracellular Oxidative Stress [PDF]

, 2012
Streptococcus pneumoniae is a Gram-positive bacterium which is a member of the normal human nasopharyngeal flora but can also cause serious disease such as pneumonia, bacteremia, and meningitis. Throughout its life cycle, S.
Anne de Jong, Barbuti, Battig, Bijlsma, Bogaert, Bortoni, Braun, Brot, Bus, Carlos J. Orihuela, Cecilia A. Hinojosa, Chae, Chen, de Ruyter, Dopazo, Duane, Even, Falord, Haasum, Hendriksen, Hiller, Hirst, Holmgren, Holmgren, Hoshi, Hoskins, Ibrahim, Imlay, Imlay, J. N. Weiser, Jetta J. E. Bijlsma, Kadioglu, Kim, Kloosterman, Kloosterman, Kuipers, Lau, Liu, Liu, Liu, Marchler-Bauer, Margolis, Martner, Matthias, McAllister, Miller, Neef, Novak, Obert, Orihuela, Oscar P. Kuipers, Park, Parra-Lopez, Paterson, Pearce, Pericone, Pericone, Pericone, Pesakhov, Petit, Potter, Ramos-Montanez, Regev-Yochay, Robertson, Rosen, Schaper, Skaar, Spellerberg, Sun, Terzaghi, Tettelin, Tseng, Vahid Farshchi Andisi, Yesilkaya, Ziegelhoffer, Zweers   +75 more
core   +23 more sources

Wzc mutation enhances virulence in CRKP ST11-KL64 via complement-mediated lysis and lipopolysaccharide release [PDF]

Microbiology Spectrum
Carbapenem-resistant Klebsiella pneumoniae (CRKP) ST11-KL64 has emerged as the dominant subclone in China. Mutations in Wzc confer a hypermucoviscous (HMV) phenotype and enhanced virulence, but how these mutations regulate capsular polysaccharide (CPS ...
Huanhuan Yan, Yufeng Dai, Kun Ye, Qiang Zhao, Na Guo, Lifeng Wang, Jiyong Yang   +6 more
doaj   +2 more sources

Attenuation of Yersinia pestis fyuA Mutants Caused by Iron Uptake Inhibition and Decreased Survivability in Macrophages

Frontiers in Cellular and Infection Microbiology, 2022
Yersinia pestis is the etiological agent of plague, a deadly infectious disease that has caused millions of deaths throughout history. Obtaining iron from the host is very important for bacterial pathogenicity. Y.
Yulu Chen, Yulu Chen, Kai Song, Kai Song, Xin Chen, Ye Li, Ruichen Lv, Qingwen Zhang, Qingwen Zhang, Yujun Cui, Yujing Bi, Yanping Han, Yafang Tan, Zongmin Du, Ruifu Yang, Ruifu Yang, Zhizhen Qi, Zhizhen Qi, Yajun Song, Yajun Song, Yajun Song   +20 more
doaj   +1 more source

Borrelia peptidoglycan interacting Protein (BpiP) contributes to the fitness of Borrelia burgdorferi against host-derived factors and influences virulence in mouse models of Lyme disease.

PLoS Pathogens, 2021
The Peptidoglycan (PG) cell wall of the Lyme disease (LD) spirochete, Borrelia burgdorferi (Bb), contributes to structural and morphological integrity of Bb; is a persistent antigen in LD patients; and has a unique pentapeptide with L-Ornithine as the ...
Yue Chen, Sean M Vargas, Trever C Smith, Sai Lakshmi Rajasekhar Karna, Taylor MacMackin Ingle, Karen L Wozniak, Floyd L Wormley, Janakiram Seshu   +7 more
doaj   +1 more source

Rim Pathway-Mediated Alterations in the Fungal Cell Wall Influence Immune Recognition and Inflammation [PDF]

, 2017
ACKNOWLEDGMENTS We acknowledge Jennifer Lodge, Woei Lam, and Rajendra Upadhya for developing and sharing the chitin and chitosan MTBH assay. We thank Todd Brennan of Duke University for providing MyD88-deficient mice.
Carol Munro, Chrissy M. Leopold Wager, Floyd L. Wormley, J. Andrew Alspaugh, Jeanette Wagener, Kyla S. Ost, Louise Walker, Michael Lorenz, Shannon K. Esher   +8 more
core   +6 more sources

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. [PDF]

PLoS Genetics, 2016
TGFβs act through canonical and non-canonical pathways, and canonical signals are transduced via Smad2 and Smad3. However, the contribution of canonical vs.
Weiguang Wang, Buer Song, Teni Anbarchian, Anna Shirazyan, Joshua E Sadik, Karen M Lyons   +5 more
doaj   +1 more source

An novel strategy for brucella differential vaccine combined with colloidal gold immunochromatographic strips based on mutants of brucella melitensis m5-90 [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2017
There is a requirement to develop an novel vaccine to distinguish between vaccinated and infected animals after vaccination. Two mutants of Brucella melitensis M5-90Δbp261 and M5-90Δbp262, knockout of the fragments amino acids 55-152 and 22-185 ...
ZHANG H, GUO L, WEI Q, ZHANG K, ZHAO S, LI H, CHEN C, ZHANG W, ZHANG Y, WANG Y   +9 more
doaj   +1 more source

The effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein. [PDF]

PLoS Pathogens, 2012
The binding of human complement inhibitors to vaccine antigens in vivo could diminish their immunogenicity. A meningococcal ligand for the complement down-regulator, factor H (fH), is fH-binding protein (fHbp), which is specific for human fH.
Peter T Beernink, Jutamas Shaughnessy, Rolando Pajon, Emily M Braga, Sanjay Ram, Dan M Granoff   +5 more
doaj   +1 more source

Global regulator DksA modulates virulence of Acinetobacter baumannii

Virulence, 2021
DksA with (p)ppGpp regulates a wide range of gene transcriptions during the stringent response. The aim of this study was to identify a DksA ortholog in Acinetobacter baumannii and clarify the roles of DksA in bacterial physiology and virulence.
Nayeong Kim, Joo Hee Son, Kyeongmin Kim, Hyo Jeong Kim, Yoo Jeong Kim, Minsang Shin, Je Chul Lee   +6 more
doaj   +1 more source