Results 41 to 50 of about 252,850 (254)

Increasing protectivity of the smallpox vaccine

Медицинская иммунология, 2022
At the present time, vast majority of human population lacks immunity against orthopoxvirus infections caused by variola (smallpox), monkeypox, cowpox, or buffalopox viruses.
S. N. Shchelkunov, A. A. Sergeev, K. A. Titova, S. A. Pyankov, S. N. Yakubitskiy   +4 more
doaj   +1 more source

In-Vivo Expression Profiling of Pseudomonas aeruginosa Infections Reveals Niche-Specific and Strain-Independent Transcriptional Programs [PDF]

, 2011
Pseudomonas aeruginosa is a threatening, opportunistic pathogen causing disease in immunocompromised individuals. The hallmark of P. aeruginosa virulence is its multi-factorial and combinatorial nature.
Bielecki, Piotr, Puchałka, Jacek, Wos-Oxley, Melissa L, Loessner, Holger, Glik, Justyna, Kawecki, Marek, Nowak, Mariusz, Tümmler, Burkhard, Weiss, Siegfried, dos Santos, Vítor A P Martins   +9 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3 [PDF]

, 2010
The enteric pathogen Salmonella enterica serovar Typhimurium causes food poisoning resulting in gastroenteritis. The S. Typhimurium effector Salmonella invasion protein A (SipA) promotes gastroenteritis by functional motifs that trigger either mechanisms
A. Maldonado-Contreras, B. A. McCormick, Barthel, C. V. Srikanth, Cherayil, Chiu, D. M. Wall, D. Zhou, Deane, H. N. Shi, Hueck, K. L. Mumy, Kim, Lee, Lee, Lee, Lilic, McCormick, McCormick, Nhan, Ohlson, Ramarao, Tran Van Nhieu, Wall, Wood, Z. Demma, Zakeri, Zhang, Zhou   +28 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A D-Alanine auxotrophic live vaccine is effective against lethal infection caused by Staphylococcus aureus

Virulence, 2018
Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections.
Miriam Moscoso, Patricia García, Maria P. Cabral, Carlos Rumbo, Germán Bou   +4 more
doaj   +1 more source

The oncogenic potential of a mutant TP53 gene explored in two spontaneous lung cancer mice models

BMC Cancer, 2020
Background Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune contexture within the tumor ...
Julian Ramelow, Christopher D. Brooks, Li Gao, Abeer A. Almiman, Terence M. Williams, Miguel A. Villalona-Calero, Wenrui Duan   +6 more
doaj   +1 more source

Deficiency of antinociception and excessive grooming induced by acute immobilization stress in Per1 mutant mice. [PDF]

PLoS ONE, 2011
Acute stressors induce changes in numerous behavioral parameters through activation of the hypothalamic-pituitary-adrenal (HPA) axis. Several important hormones in paraventricular nucleus of the hypothalamus (PVN) play the roles in these stress-induced ...
Jing Zhang, Zhouqiao Wu, Linglin Zhou, Huili Li, Huajing Teng, Wei Dai, Yongqing Wang, Zhong Sheng Sun   +7 more
doaj   +1 more source