Results 231 to 240 of about 120,729 (267)

SCID Mice With HIV Encephalitis Develop Behavioral Abnormalities

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 1998
Severe combined immunodeficient (SCID) mice inoculated intracerebrally (i.c.) with HIV-infected human monocytes develop brain pathology similar to that in humans with HIV encephalitis. This includes HIV-positive macrophages and multinucleated giant cells, astrogliosis, microglial nodules, and neuronal dropout. These xenografts survive about 1 month. To
N, Avgeropoulos, B, Kelley, L, Middaugh, S, Arrigo, Y, Persidsky, H E, Gendelman, W R, Tyor   +6 more
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Growth of Human Lymphoma Cells in SCID Mice

Leukemia & Lymphoma, 1992
Two EBV-negative human lymphoma cell lines raised in this laboratory and peripheral blood cells of a patient with large cell lymphoma in leukemic phase were injected intravenously or intraperitoneally into C.B.17 SCID mice. One line (OCI-LY18) was derived from the pleural fluid of a patient with a large cell, immunoblastic malignant lymphoma.
H, Chang, S, Leeder, V A, Cook, B, Patterson, M, Dosch, M D, Minden, H A, Messner   +6 more
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Spontaneous and experimental infections in scid and scid/beige mice.

Laboratory animal science, 1993
Severe combined immunodeficient (scid) mice are valuable animals to study a variety of physiologic and disease processes. Their capacity to support multiple tissue xenografts permits these mice to be used as intermediate models for host-specific, fastidious organisms for which a small animal model has not been available previously.
D H, Percy, J R, Barta
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Human Humoral Immunity in SCID Mice

1995
In 1983, Bosma and colleagues discovered an autosomal recessive mutation (scid) in the C.B-17 mouse strain that resulted in marked deficiencies in both humoral and cell-mediated immunities.1 The mutant locus was mapped close to the mahoganoid locus, centromeric to the Ig light chain locus on chromosome 16.2 The mutation appears to impair the ...
Mohammad R. Abedi, Lennart Hammarström, Birger Christensson, C. I. Edvard Smith   +3 more
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[Histological and cytofluorometric investigations of immunodeficient CB17 scid/scid mice].

Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1992
Blood cell differentiation and development is under the control of a number of genes, and mutations in one of these genes could result in an immunodefective phenotype. Mice of the CB17 scid/scid ("severe combined imunodeficient") strain are characterized by a mutation which affects early lymphoid differentiation and lack functional T and B lymphocytes.
C H, Ladel, U, Bamberger, H, Püschner
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Defective repair of radiation-induced chromosomal damage in scid/scid mice.

Cytogenetics and cell genetics, 1992
The murine severe combined immunodeficiency (scid) mutation interferes with normal recombination of immunoglobulin and T-cell receptor genes. This immunologic defect results in a lack of fully differentiated B and T cells in scid/scid mice. Animals homozygous for the scid mutation also display increased sensitivity to the damaging effects of ionizing ...
Disney, J E, Barth, A L, Shultz, L D
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Spontaneous nonthymic tumors in SCID mice.

Comparative medicine, 2012
SCID mice provide an excellent platform for cancer research. Because of their lack of immunity, SCID mice readily succumb to infectious pathogens and therefore must be maintained in an SPF, barrier-protected environment. Although SPF and barrier facilities prevent infection, SCID mice remain prone to premature death due in part to a high prevalence of ...
Peigen, Huang, Susan V, Westmoreland, Rakesh K, Jain, Dai, Fukumura   +3 more
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Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 1994
SCID and SCID/beige mice were used to study the pathogenesis of B. catarrhalis administered by intranasal, intraperitoneal or intravenous routes. Challenged adult animals did not appear overtly clinically ill. Similar symptoms were observed regardless of the challenge route, and pretreatment of mice with human transferrin did not enhance clinical ...
R E, Harkness, M J, Guimond, B A, McBey, M H, Klein, D H, Percy, B A, Croy   +5 more
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Human T-Cell Development in SCID-hu Mice

1995
Thymic development proceeds in stages whereby immature T-cell precursors lacking T-cell receptor (TCR) and CD4 and CD8 expression (double negative: DN), progress through a TCRlo CD4+CD8+ (double positive: DP) stage before differentiating into mature TCRhi CD4+CD8− or CD4−CD8+ (single positive: SP) thymocytes.1 DP thymocytes are subjected to positive ...
RONCAROLO , MARIA GRAZIA, Schols D, Namikawa R, de Vries JE   +3 more
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hu-SCID MICE

1998
Gianvito Martino, Luigi M.E. Grimaldi
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