Results 221 to 230 of about 120,729 (267)

Construction of Human‐SCID Chimeric Mice

Current Protocols in Immunology, 1998
AbstractUntil recently, testing of new therapeutic agents has relied extensively upon the use of mice and nonhuman primates for in vivo preclinical studies. Unfortunately, these animal models do not always mimic the physiological and pathophysiological processes that occur in humans.
Maria Grazia, Roncarolo, José M, Carballido   +1 more
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Human Hematopoiesis in SCID Mice

1995
The hematopoietic system is organized as a hierarchy where the majority of the cells are mature, and therefore, need to be continuously replenished from a small pool of immature progenitors. Ultimately, the entire hematopoietic system is derived from stem cells that have extensive proliferative and differentiation capacity and give rise to all myeloid ...
Maria-Grazia Roncarolo, Bruno Péault, Reiko Namikawa   +2 more
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SCID mice as models for parasitic infections

Parasitology Today, 1993
Mice with severe combined immunodeficiency (SCID mice) have become a favored model system for the study of many parasitic diseases. In this review, Samuel Stanley Jr and Herbert Virgin IV provide a brief overview of the biology of the SCID mouse, and review some examples of how the SCID mouse model has been applied to the study of the immunology of a ...
S L, Stanley, H W, Virgin
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Branhamella catarrhalispathogenesis in SCID and SCID/beige mice

APMIS, 1993
SCID and SCID/beige mice were used to study the pathogenesis of B. catarrhalis administered by intranasal, intraperitoneal or intravenous routes. Challenged adult animals did not appear overtly clinically ill. Similar symptoms were observed regardless of the challenge route, and pretreatment of mice with human transferrin did not enhance clinical ...
ROBIN E. HARKNESS, MARIE-JOSÉE GUIMOND, BETTY-ANNE McBEY, MICHEL H. KLEIN, DEAN H. PERCY, B. ANNE CROY   +5 more
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Transfer of Diabetes from Prediabetic NOD Mice to NOD-SCID/SCID Mice: Association with Pancreatic Insulin Content

Hormone and Metabolic Research, 2005
Splenocytes from prediabetic female NOD mice can transfer diabetes to NOD-SCID mice. Whereas the kinetics of disease transfer was shown to be a function of the age of donor splenocytes, information is scarce as to how the stage of autoimmune disease, as evaluated by pancreatic insulin content, is related to the diabetogenic potency of splenic T-cells ...
M, Füchtenbusch, E, Larger, K, Thebault, C, Boitard   +3 more
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SCID mice as immune system models

Current Opinion in Immunology, 1991
C.B-17 scid/scid mice are born with severe combined immunodeficiency. This defect in the maturation of T and B cells has provided a novel experimental system in which to study normal lymphoid differentiation and function in mouse and man.
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Pulmonary alveolar proteinosis in SCID mice.

American Journal of Respiratory Cell and Molecular Biology, 1995
Pulmonary alveolar proteinosis (PAP) is an uncommon disorder of unknown origin in which the alveoli are filled with lipoproteinaceous material, including surfactant. We have characterized a spontaneously occurring lesion in the lungs of CB.17 scid/scid mice which resembles PAP in humans.
V M, Jennings, D L, Dillehay, S K, Webb, L A, Brown   +3 more
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Viral pathogenesis in hu-PBL-SCID mice

Seminars in Immunology, 1996
The transplantation of human cells into immunodeficient mice has provided new models for human immune function, infection by pathogenic viruses that grow in lymphocytes or other hematopoietic cells, and development of hematopoietic lineages. SCID mice reconstituted with adult peripheral blood mononuclear cells (hu-PBL-SCID mice) maintain some ...
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Human Taenia in Severe Combined Immunodeficiency (SCID) Mice

Parasitology Today, 1999
A rodent model for the development of the larval stages of human taeniid tapeworms would help advance immunodiagnosis in human and domestic animals and vaccine development for cysticercosis cellulosae or bovis in domestic animals. Here, Akira Ito and Mamoru Ito review recent results demonstrating the potential of the severe combined immunodeficiency ...
A, Ito, M, Ito
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Engraftment of chronic myeloid leukemia in SCID mice

Hematological Oncology, 1998
Chronic myeloid leukemia (CML) is a clonal disorder of primitive hematopoietic stem cells characterized by a reciprocal translocation between chromosomes 9 and 22. Animal models of CML would be useful to study the biology and potential therapies in this disease.
C F, Hoyle, R S, Negrin
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