Results 201 to 210 of about 2,313,243 (300)

Epitope specificity of antibody-mediated protection induced in mice by the malaria vaccine RTS,S/AS01. [PDF]

NPJ Vaccines
Flores-Garcia Y, Salgado-Jimenez B, Park M, Mathis-Torres S, Locke E, MacGill RS, Moskovitz R, Wilson IA, Zavala F.   +8 more
europepmc   +1 more source

Case Report: Hypomyelinating Leukodystrophy Type 20 (HLD20) With Novel CNP Gene Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT This case report describes a child with hypomyelinating leukodystrophy type 20 (HLD20), a rare neurodegenerative disorder characterized by impaired myelin formation. The patient presented with multiple neurodevelopmental abnormalities, including delayed motor milestones, seizures, and abnormal facial features.
Malak Alghamdi, Ghaida Alghamdi, Khalid Hundallah, Dima Jamjoom, Naif Almontashiri, Essa Alharbi, Muhammad Umair, Majid Alfadhel   +7 more
wiley   +1 more source

Viral-mediated knockdown of Atxn2 attenuates TDP-43 pathology and muscle dysfunction in the PFN1^C71G ALS mouse model. [PDF]

Acta Neuropathol Commun
Hawley ZCE, Li X, Bodnar D, Gu Y, Luo Y, Ferretti D, Sheehy A, Driscoll R, Zavodszky MI, Cao S, Isaza I, Jandreski L, Liu Y, Carlile T, Lo SC, Grimard A, Bourque S, Utturkar A, Desmarais S, Arnold HM, Huh D, Guilmette E, Kwon DY.   +22 more
europepmc   +1 more source

Repurposing With Purpose: Treatment of Bachmann–Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp, Elizabeth A. VanSickle, Julianne Michael, Chad R. Schultz, Kelly Nguyen, Melissa Hoefer, Surender Rajasekaran, André S. Bachmann   +7 more
wiley   +1 more source

The Beneficial Impact of a Novel Pancreatic Polypeptide Analogue on Islet Cell Lineage. [PDF]

Int J Mol Sci
Zhu W, Tanday N, Flatt PR, Irwin N.
europepmc   +1 more source

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source

The NLRP3 inflammasome pathway contributes to chronic inflammation in experimental autoimmune uveitis

Animal Models and Experimental Medicine, EarlyView.
The present study investigates the role of the NLRP3 inflammasome in the chronicity of ocular inflammation in uveitis using the experimental autoimmune uveitis (EAU) model. Whole eyes collected from EAU mice, 12 weeks post induction, were sectioned and subjected to immunohistochemistry. The confocal images from these sections were then assessed for the
Avik Shome, Ilva D. Rupenthal, Rachael L. Niederer, Odunayo O. Mugisho   +3 more
wiley   +1 more source

Application of Humanized MHC Transgenic Mice in the Screening of HLA-Restricted T Cell Epitopes for Influenza Vaccines. [PDF]

Vaccines (Basel)
Wei Y, Sun K, Han X, Sun Y, Zhang J, Wang Y, Yin Q, Yang T, Yuan K, Li M, Zhao G.   +10 more
europepmc   +1 more source

Green‐to‐red spectral labeling: A novel polysynaptic retrograde tracing strategy in the marker footprint mouse model

Animal Models and Experimental Medicine, EarlyView.
To compensate for the fluorescence loss in rabies virus–derived neuronal tracing tools caused by non‐cytolytic immune clearance (NCLIC) in retrograde tracing, we developed a novel green‐to‐red spectral labeling (GTR) strategy based on the NCLIC phenomenon and developed a novel marker footprints mouse to support the strategy.
Yige Song, Jinyu Zeng, Yunyun Han, Aodi He, Houze Zhu   +4 more
wiley   +1 more source

New Mouse Lines That Drive Tetracycline-Controlled Gene Expression in a Small Subset of Spinal Cord Dorsal Horn Neurons. [PDF]

eNeuro
Fyrberg E, Learnard H, Lee S, Jun YW, Gao FB.   +4 more
europepmc   +1 more source