Results 261 to 270 of about 1,897,120 (285)

HLA-G transgenic mice

Journal of Reproductive Immunology, 1999
We have generated a number of transgenic mice using DNA segments derived from the HLA-G gene. Using these mice we have examined the pattern of expression dictated by HLA-G promoter elements in mice and shown that HLA-G functions both as a restriction element and a transplantation antigen recognized by murine T cells.
David H. Munn, Min Zhou, Simon J. Conway, Andrew L. Mellor   +3 more
openaire   +3 more sources

Mutations in Transgenic Mice

1989
The induction of mutations in transgenic mice represents a powerful experimental tool as it not only allows the derivation of precise animal models for human hereditary diseases but also permits a systematic genetic dissection of the mammalian genome.
Rudolf Jaenisch, Tetsuo Noda, Douglas A. Gray, Hans Weiher   +3 more
openaire   +2 more sources

Transgenic Mice Modelling

2012
Although the prion protein (PrP) was discovered in the early 1980s, there is still a considerable lack of knowledge of the normal function of the PrP protein and its precise role in the infectious process of transmissible spongiform encephalopathies (TSEs) or prion diseases.
Jean Manson, Enrico Cancellotti, Rona Wilson, Abigail B. Diack, Barry Bradford, Matthew Bishop   +5 more
openaire   +2 more sources

Reporter genes in transgenic mice

Transgenic Research, 1994
Although in vivo models utilizing endogenous reporter genes have been exploited for many years, the use of reporter transgenes to dissect biological issues in transgenic animals has been a relatively recent development. These transgenes are often, but not always, of prokaryotic origin and encode products not normally associated with eukaryotic cells ...
Cunqi Cui, Maqsood A. Wani, David C. Wight, Peter J. Stambrook, John J. Kopchick   +4 more
openaire   +2 more sources

Transgenic RNA Interference in Mice

Physiology, 2007
The discovery that small interfering RNA duplexes (siRNA) can silence gene expression in mammalian cells has revolutionized biomedical research. The most successful application of the discovery has been to study gene function in cultured human or mouse cells. However, the knockdown effect of siRNA is only transient.
Xue Gao, Pumin Zhang
openaire   +3 more sources

Development of btk Transgenic Mice

1995
B cell development is characterized by the orderly expression of cell surface markers and responses to specific activation signals [1]. Tyrosine kinases are involved in signalling pathways that regulate these events [2]. Bruton’s tyrosine kinase (Btk) is a tyrosine kinase expressed in B and myeloid cells [3,4].
E. A. Faust, Owen N. Witte, Douglas C. Saffran, David J. Rawlings   +3 more
openaire   +3 more sources

Transgenic mice

Cell, 1985
R D, Palmiter, R L, Brinster
openaire   +2 more sources

Insertional Mutations in Transgenic Mice

1989
Insertional mutagenesis represents a promising approach to the identification of new genes involved in mammalian development. In this paper, we have presented a brief review of the literature on the analysis of mutations caused by DNA and retroviral insertion into the mouse genome.
James J. Lee, Glenn L. Radice, Hyeung Jin Son, William L. Perry, Frank Costantini, Kiran Chada   +5 more
openaire   +3 more sources

Transgenic RNA Interference in Mice

2008
RNA interference (RNAi) is a powerful tool in deciphering gene function. It has been used extensively, especially in cultured mammalian cells. We have shown that RNAi-induced gene silencing can be generated in mice. With conventional transgenic techniques, shRNA-expressing constructs can be introduced into one-cell mouse embryos. The transgenic animals
openaire   +3 more sources

Transgenic mice and the pathogenesis of poliomyelitis

1994
Transgenic mice expressing the cell receptor for poliovirus have been generated and are susceptible to poliovirus infection. TgPVR mice have been used to answer questions about the pathogenesis of poliovirus infection. Despite the widespread pattern of PVR expression, poliovirus infection in TgPVR mice is restricted to only a few sites, indicating that
R. Ren, Vincent R. Racaniello
openaire   +3 more sources