Results 271 to 280 of about 2,313,243 (300)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Generation of a Transgenic Mouse Model for Investigating Mitochondria in Sperm. [PDF]

Cells
Sarkar H, Batta SR, Wadhwa N, Majumdar SS, Pradhan BS.   +4 more
europepmc   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

An update on mammalian and non-mammalian animal models for biomarker development in neurodegenerative disorders. [PDF]

Cell Mol Life Sci
Mishra R, Upadhyay A.
europepmc   +1 more source

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

Non-viral generation of transgenic non-human primates via the piggyBac transposon system. [PDF]

Nat Commun
Nakaya M, Iwatani C, Tsukiyama-Fujii S, Mieda A, Tarumoto S, Tsujimura T, Yamamoto T, Ichikawa T, Nakamura T, Terakado I, Kawamoto I, Nakagawa T, Itagaki I, Saitou M, Tsuchiya H, Tsukiyama T.   +15 more
europepmc   +1 more source

Murine Non-Transgenic Models of Alzheimer's Disease Pathology: Focus on Risk Factors. [PDF]

Brain Sci
Hernández-Rodríguez M, Vega López JM, Martínez-Rosas M, Nicolás-Vázquez MI, Mera Jiménez E.   +4 more
europepmc   +1 more source

Evaluation of the immunological functions of placental alkaline phosphatase <i>in vivo</i> using ALPP transgenic mice. [PDF]

Front Immunol
Chen TC, Ng KF, Chen N, Pan YL, Cheng CA, Wu HC, Hsueh YJ, Chiang NY, Lin HH.   +8 more
europepmc   +1 more source

Microbiota does not influence tumor development in two models of heritable cancer. [PDF]

mBio
Spring J, Gurbuxani S, Golovkina T.
europepmc   +1 more source

Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study. [PDF]

Proc Natl Acad Sci U S A
Yoon H, Gerdes LA, Beigel F, Sun Y, Kövilein J, Wang J, Kuhlmann T, Flierl-Hecht A, Haller D, Hohlfeld R, Baranzini SE, Wekerle H, Peters A.   +12 more
europepmc   +1 more source