Results 141 to 150 of about 3,863,409 (286)

Neuronal Overexpression of Glycogen Synthase Kinase-3β Accelerates Age-Related Glial, Vascular, and Inflammatory Remodeling of the Murine Dentate Gyrus. [PDF]

Glia
Prádanos-Senén AV, Rodríguez-Moreno CB, Llorens-Martín M.   +2 more
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Astrocytic EAAT-2 Upregulation Supports Neuro-Axonal Homeostasis in Chronic Inflammatory CNS Lesions. [PDF]

Glia
Reukauf L, Margineanu A, Muinjonov B, Chen J, Cui Y, Rosiewicz K, Radbruch H, Munro I, Alisch M, Siffrin V.   +9 more
europepmc   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1-Dependent Suppression of ROMK. [PDF]

Acta Physiol (Oxf)
Kawarazaki W, Ayuzawa N, Nishimoto M, Hirohama D, Ueda K, Marumo T, Fujita T.   +6 more
europepmc   +1 more source

ACATALASEMIC MICE [PDF]

Proceedings of the National Academy of Sciences, 1964
Feinstein, R N, Seaholm, J E, Howard, J B, Russell, W L   +3 more
openaire   +2 more sources

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Myeloid-Derived Growth Factor Alleviates Diabetic Non-Alcoholic Fatty Liver Disease by Up-Regulating ABCA1 and ABCG1 Expression via the AMPK/PPARγ/LXRα Pathway. [PDF]

J Cell Mol Med
Chen Z, Meng B, Wang B, Ding Y.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Imaging [18F]FDG PET/CT pilot study of nicotinic acetylcholinergic receptor α2 knock-out mice and α2 hypersensitive mice compared to control mice: Male-female differences and nicotine effects. [PDF]

PLoS One
Liang C, Tucker TE, Coronel ADL, Nguyen EHN, Nguyen JL, Intskirveli I, Lazar R, Metherate R, Mukherjee J.   +8 more
europepmc   +1 more source