Results 51 to 60 of about 3,863,409 (286)

An entropy-based method to measure phase-locking between LFP and spikes

AIP Advances, 2023
Phase-locking between local field potential and spikes has been widely investigated through neurophysiological analysis. Two indices most frequently adopted traditionally include the mean resultant length and p of the Rayleigh test.
Xing-Yan Dang, Han-Ting Xu, Xin-Yu Bao, Yun-Yong Xie, Jing-Ning Zhu, Xiao-Yang Zhang, Xiao-Lin Huang   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

South Dakota State College Stage Production of 'Two Blind Mice'

, 1959
Scene from the South Dakota State College stage production of 'Two Blind Mice' performed on stage at Doner ...
Spewack, Samuel. 1899-1971. Two Blind Mice
core   +6 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Effect of Aspartame on Histological and Histometrical Structure of Prostate Gland in Adult Mice

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and objectives: Aspartame is a low-calorie synthetic sweetener that is consumed by 200 million subjects worldwide. In recent years, negative effects of aspartame have been shown on various tissues of the body.
Hassan Morovvati, Zabihollah Khaksar, Mohammad-Taghi Sheibani, Hojat Anbara, Mohsen Amini Kafiabad, Hamid Reza Moradi   +5 more
doaj  

Peripheral blood DNA methylation and neuroanatomical responses to HDACi treatment that rescues neurological deficits in a Kabuki syndrome mouse model

Clinical Epigenetics, 2023
Background Recent findings from studies of mouse models of Mendelian disorders of epigenetic machinery strongly support the potential for postnatal therapies to improve neurobehavioral and cognitive deficits. As several of these therapies move into human
Sarah Jessica Goodman, Teresa Romeo Luperchio, Jacob Ellegood, Eric Chater-Diehl, Jason P. Lerch, Hans Tomas Bjornsson, Rosanna Weksberg   +6 more
doaj   +1 more source

Of mice and men [PDF]

The EMBO Reports, 2004
The third biannual Keystone meeting on nuclear factor‐κB biology and pathology took place in Snowbird, Utah, USA, between 11 and 16 January 2004, and was organized by U. Siebenlist, A. Rao and S. Ghosh ![][1] Few signalling molecules attract sufficient attention to warrant their own scientific field, but one such example is nuclear factor‐κB (NF‐κB).
Ben‐Neriah, Yinon, Schmitz, M Lienhard
openaire   +3 more sources