Results 81 to 90 of about 4,155,608 (362)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus. [PDF]
, 2013 BackgroundThe current study was conducted to establish animal models (including mouse and ferret) for the novel avian-origin H7N9 influenza virus.FindingsA/Anhui/1/2013 (H7N9) virus was administered by intranasal instillation to groups of mice and ...
Bao, Linlin +19 more
core +3 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Tourist behaviors and needs for the development of creative Thai traditional sports tourism marketing for special interest tourism [PDF]
African Journal of Hospitality, Tourism and Leisure, 2020 This study aimed to investigate tourist behaviors and needs for the development of creative Thai traditional sports tourism to support special interest tourism.
Asst. Prof. Dr. Thirachaya Chaigasem +1 more
doaj
Heat shock transcription factor 1 preserves cardiac angiogenesis and adaptation during pressure overload [PDF]
, 2008 To examine how heat shock transcription factor 1 (HSF1) protects against maladaptive hypertrophy during pressure overload, we subjected HSF1 transgenic (TG), knockout (KO) and wild type (WT) mice to a constriction of transverse aorta (TAC), and found ...
Aijun Sun +16 more
core +1 more source
Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome. [PDF]
, 2016 The loss-of-function mutations of serine protease inhibitor, Kazal type 1 (SPINK1) gene are associated with human chronic pancreatitis, but the underlying mechanisms remain unknown. We previously reported that mice lacking Spink3, the murine homologue of
Araki, Kimi +15 more
core +2 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Frontiers in Physiology, 2020 Fascia can become rigid and assume a fibrotic pattern due to inflammatory processes. Manipulation of the fascial system (MFS), manual technique targeting connective tissues, is commonly used in clinical practice in pain management. We aimed to verify MFS
Maria Elisa Duarte França +9 more
doaj +1 more source
Effect of Predators of Juvenile Rodents on the Spread of the Hantavirus Epidemic [PDF]
arXiv, 2005 Effects of predators of juvenile mice on the spread of the Hantavirus are analyzed in the context of a recently proposed model. Two critical values of the predation probability are identified. When the smaller of them is exceeded, the hantavirus infection vanishes without extinguishing the mice population.
arxiv
Regulation of Mouse Learning and Mood by the Anti-Inflammatory Cytokine Interleukin-10 [PDF]
2020. Doctoral dissertation, University of Miami Miller School of
Medicine. University of Miami Research Repository.
https://scholarship.miami.edu/esploro/outputs/991031524489402976 ISBN:
9798698577058, 2023 Major depressive disorder is a widespread mood disorder. One of the most debilitating symptoms patients often experience is cognitive impairment. Recent findings suggest that inflammation is associated with depression and impaired cognition. Pro-inflammatory cytokines are elevated in the blood of depressed patients and impair learning and memory ...
arxiv