From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Ready to be a host?: The potential development guidelines of sport tourism in Buriram Province, Thailand [PDF]
African Journal of Hospitality, Tourism and Leisure, 2020 Tourism is a major industry in the world. Sport tourism is considered to be a part of tourism created through of the integration of sports and tourism.
Asst. Prof. Dr. Thirachaya Chaigasem +1 more
doaj
Automated building image extraction from 360{\deg} panoramas for postdisaster evaluation
, 2019 After a disaster, teams of structural engineers collect vast amounts of images from damaged buildings to obtain new knowledge and extract lessons from the event. However, in many cases, the images collected are captured without sufficient spatial context.
Bilionis, Ilias +3 more
core +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Management for the transformation of a Historical City into a MICE City supporting the idea of MICE business in AEC. [PDF]
African Journal of Hospitality, Tourism and Leisure, 2019 This mixed method research investigated the measures that had been taken in order to transform a historical city into a MICE city in order to cater to MICE business, which has been rampaging under the prevailing AEC.
Asst. Prof. Dr. Thirachaya Chaigasem
doaj
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Policies to Promote Medical Tourism in Korea: A Narrative Review
Iranian Journal of Public Health, 2018 Background: There is a growing global demand for medical tourism while more people are moving across borders in Asia, offering new opportunities to the high-value medical tourism market.
Byung Ro SEO, Sam-Hun PARK
doaj
Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [PDF]
, 2017 TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitialdamage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy(DN).
Birnbaumer, Lutz +5 more
core
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
The effect of environment on post surgical overall well-being and pain sensitivity in an animal model [PDF]
, 2016 With chronic post surgical pain affecting up to one third of patients undergoing surgeries and the price of treatment being astoundingly high there has been a transition in research to investigate and identify risk factors. Through identification of risk
Reddy, Archana
core +1 more source