Results 81 to 90 of about 117,565 (253)

Ex Vivo Conjunctival Retention and Transconjunctival Transport of Poorly Soluble Drugs Using Polymeric Micelles

open access: yesPharmaceutics, 2019
This paper addresses the problem of ocular delivery of lipophilic drugs. The aim of the paper is the evaluation of polymeric micelles, prepared using TPGS (d-α-Tocopheryl polyethylene glycol 1000 succinate), a water-soluble derivative of Vitamin E ...
Silvia Pescina   +7 more
doaj   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

open access: yesAdvanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon   +27 more
wiley   +1 more source

Curcumin-loaded redox response of self-assembled micelles for enhanced antitumor and anti-inflammation efficacy [PDF]

open access: yes, 2017
Shuang Zhao,1,* Litao Ma,1,* Chengwen Cao,1 Qianqian Yu,1 Lanmei Chen,1,2 Jie Liu1 1Department of Chemistry, Jinan University, Guangzhou, 2Department of Chemistry, School of Pharmacy, Guangdong Medical University, Zhanjiang, People’s Republic of ...
Shuang Zhao   +11 more
core   +1 more source

Regulating Droplet Dynamics via Wormlike Micelle Networks: From Splash Suppression to Precise Confined Spreading

open access: yesAdvanced Science, EarlyView.
As displayed in Graphical Abstract image.tif, a molecular‐design strategy precisely tailors high‐speed droplet dynamics through programmed surfactant co‐assembly. The structural transition into an entangled wormlike micelle network completely suppresses stochastic splashing on fibrous substrates.
Shuling Liu   +6 more
wiley   +1 more source

Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin

open access: yesInternational Journal of Nanomedicine, 2012
Jingmou Yu,1 Xin Xie,1 Meirong Zheng,1 Ling Yu,2 Lei Zhang,1 Jianguo Zhao,1 Dengzhao Jiang,1 Xiangxin Che11Key Laboratory of Systems Biology Medicine of Jiangxi Province, College of Basic Medical Science, Jiujiang University, Jiujiang, 2Division of ...
Zhao J   +7 more
doaj  

pH-Sensitive Micelles Based on Double-Hydrophilic Poly(methylacrylic acid)-Poly(ethylene glycol)-Poly(methylacrylic acid) Triblock Copolymer

open access: yesNanoscale Research Letters, 2009
pH-sensitive micelles with hydrophilic core and hydrophilic corona were fabricated by self-assembling of triblock copolymer of poly(methylacrylic acid)-poly(ethylene glycol)-poly(methylacrylic acid) at lower solution pH.
Tao Youhua   +5 more
doaj   +1 more source

The synthesis and ring-opening polymerisation of novel cyclic esters from malic acid [PDF]

open access: yes
The work in this thesis is directed towards the preparation of cyclic ester monomers using malic acid as a renewable resource. Their subsequent controlled ring-opening polymerisation (ROP) to yield functionalised poly(ester)s is studied and ...
Pounder, Ryan J.
core  

Doxorubicin-incorporated polymeric micelles composed of dextran-b-poly(DL-lactide-co-glycolide) copolymer

open access: yes, 2011
Young-Il Jeong1,*, Do Hyung Kim1,2,*, Chung-Wook Chung1, Jin-Ju Yoo1, Kyung Ha Choi1, Cy Hyun Kim1,2, Seung Hee Ha1, Dae Hwan Kang1,2 1National Research and Development Center for Hepatobiliary Cancer, Pusan National University Yangsan Hospital, Yangsan,
Jeong YI   +9 more
core   +1 more source

In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration

open access: yesAdvanced Science, EarlyView.
Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang   +5 more
wiley   +1 more source

Engineering Ultrastable Intrinsic Radicals: Graphene Quantum Dots With NIR‐II Emission for Dynamic Deep‐Tissue Bioimaging

open access: yesAdvanced Science, EarlyView.
Stable radicals are attractive for photonic and quantum information technologies but are often limited by instability. We stabilize intrinsic radicals in graphene quantum dots via 2D polymerization of perylene derivatives, where bilayer defect confinement suppresses quenching (100–500 K).
Qin Xu   +9 more
wiley   +1 more source

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