Results 91 to 100 of about 1,382,076 (243)

pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study

Pharmacology Research & Perspectives, 2019
Despite intensive treatments including temozolomide (TMZ) administration, glioblastoma patient prognosis remains dismal and innovative therapeutic strategies are urgently needed.
Angélique Stéphanou, Annabelle Ballesta   +1 more
doaj   +1 more source

PK-toimialabarometri : Luonnontuoteala, syksy 2016

, 2016
Suomen pk-yritysten suhdannenäkymät ovat kehittyneet myönteisesti syksystä 2015. Koko maan pk-yrityksistä 43 % arvioi suhdanteiden paranevan ja 11 % huononevan (saldoluku +32). Syksyllä 2015 saldoluku oli +9. Luonnontuotealalla uskotaan myös suhdanteiden

core  

From Top to Bottom: Manufacturing Process‐Context Aware Resolution of Energy Device Electrodes Through a 3D Diffusion Generative Model

Advanced Energy Materials, EarlyView.
The application of a generative diffusion model, enhanced with a training data augmentation pipeline retaining the manufacturing process context of electrode microstructures, leads to improved fidelity of the through‐plane tortuosity factor in the AI generated samples.
Victor Ramirez‐Camacho, Siwar Ben Hadj Ali, Maxence Desnoyers, Francisco Fernandez, Nassima Benammar, Alejandro A. Franco   +5 more
wiley   +1 more source

PK-resistant PrP species are responsible for acute synaptotoxicity.

, 2018
(A) PrP immuno-depletion selectively depleted ~77 ± 12% of PrPC (dNBH) from cNBH and ~77 ± 9% total PrP species and 96 ± 4% of PK-resistant PrP (dM1000) from cM1000 relative to the normal rabbit serum (NRS) controls.
Blaine Roberts (2250916), Paul Anthony Adlard (5590958), Matteo Senesi (5614373), Abu Mohammed Taufiqual Islam (5616035), Shannon Sarros (5616038), Steven John Collins (5616041), Victoria Lawson (585860), Feng Chen (25347), David Isaac Finkelstein (5614367), Harold Arthur Coleman (5614370), Simote Totauhelotu Foliaki (5614364), Victoria Lewis (331841)   +11 more
core   +1 more source

When Biology Meets Medicine: A Perspective on Foundation Models

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu, Yuxing Wang, Limin Zou, Jing Huang   +3 more
wiley   +1 more source

PK-toimialabarometri : Elintarviketeollisuus, syksy 2016

, 2016
Suomen pk-yritysten suhdannenäkymät ovat kehittyneet myönteisesti syksystä 2015. Koko maan pk-yrityksistä 43 % arvioi suhdanteiden paranevan ja 11 % huononevan (saldoluku +32, syksyllä 2015 +9).

core   +1 more source

464 Creating Pragmatic Tools for Reliable Kidney Function Measurement in Patients with Kidney Impairment

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Estimating kidney function for drug dosing poses safety and efficacy concerns with critical medications. This study aims to develop a pragmatic method for measuring kidney function, ensuring that critical clinical decision points based ...
Levi Hooper, Amit Pai
doaj   +1 more source

How does the Kids SIPsmartER program impact the sugar‐sweetened beverage intake of students: An investigation beyond total treatment effect in randomized controlled trial

American Journal of Agricultural Economics, EarlyView.
Abstract This study develops and empirically estimates a structural framework to decompose the causal pathways of multilevel behavioral interventions targeting adolescent health behaviors. We apply this framework to the Kids SIPsmartER (KSS) program, a 6‐month, school‐based intervention evaluated through a clustered randomized controlled trial in rural
Naveen Abedin, Wen You, Annie Reid, Kathleen Porter, Brittany Kirkpatrick, Jamie Zoellner   +5 more
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of linezolid in plasma/cerebrospinal fluid in patients with cerebral hemorrhage after lateral ventricular drainage by Monte Carlo simulation

Drug Design, Development and Therapy, 2018
Xiaofei Wu,1 Yan Tang,1 Xiaohua Zhang,1 Chenchen Wu,2 Lingti Kong3 1Department of Emergency Internal Medicine, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, People’s Republic of China; 2Department of Endocrinology, the ...
Wu X, Tang Y, Zhang X, Wu C, Kong L
doaj  

Zebrafish xenograft models as a fast platform for metastasis diagnosis and cisplatin response of head and neck squamous cell carcinoma

Animal Models and Experimental Medicine, EarlyView.
A zebrafish xenograft model accurately distinguishes metastatic from non‐metastatic HNSCC and recapitulates cisplatin sensitivity/resistance patterns. Using patient‐derived tumors, it predicts individual therapeutic responses, offering a rapid, clinically applicable platform for guiding personalized treatment. Abstract Background Head and neck squamous
Lu Chen, Shu Sun, Yujia Liu, Liehao Jiang, Cuiyun Wu, Ting Liu, Yujiao Zhao, Yuwei Liu, Lu Liu, Qi Wang, Xiaowei Zheng, Ping Huang   +11 more
wiley   +1 more source