Results 91 to 100 of about 24,159 (244)

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer   +24 more
wiley   +1 more source

Beyond goniometry: 3D digital twinning of droplets from a single image

open access: yesDroplet, EarlyView.
We present a method to produce physics‐informed three‐dimensional digital twins of droplets from a single image for wettability analyses. We validate the method with goniometry and demonstrate its capabilities with advancing‐receding contact angle measurements, irregularly shaped droplets, and multi‐droplet systems, indicating strong potential for in ...
Isaac Berk, Emilie Luong, H. Jeremy Cho
wiley   +1 more source

464 Creating Pragmatic Tools for Reliable Kidney Function Measurement in Patients with Kidney Impairment

open access: yesJournal of Clinical and Translational Science
OBJECTIVES/GOALS: Estimating kidney function for drug dosing poses safety and efficacy concerns with critical medications. This study aims to develop a pragmatic method for measuring kidney function, ensuring that critical clinical decision points based ...
Levi Hooper, Amit Pai
doaj   +1 more source

A consensus roadmap for post‐traumatic epilepsy: Clinical biomarkers, research priorities, policy barriers, and pathways to interventional trials

open access: yesEpilepsia, EarlyView.
Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier   +82 more
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of linezolid in plasma/cerebrospinal fluid in patients with cerebral hemorrhage after lateral ventricular drainage by Monte Carlo simulation

open access: yesDrug Design, Development and Therapy, 2018
Xiaofei Wu,1 Yan Tang,1 Xiaohua Zhang,1 Chenchen Wu,2 Lingti Kong3 1Department of Emergency Internal Medicine, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, People’s Republic of China; 2Department of Endocrinology, the ...
Wu X, Tang Y, Zhang X, Wu C, Kong L
doaj  

Path-Aware Knowledge Injection for Fine-Grained Emotion Recognition in Mental Health Counseling

open access: yesIEEE Access
Fine-grained, multi-label emotion recognition in textual dialogues, particularly in contexts like mental health counseling, presents significant challenges due to the complexity and concurrency of human emotions.
Haili Zhang, Dun Niu
doaj   +1 more source

Preliminary Development of Solid Dispersion for an Insoluble Compound ZL006 by Miniaturized Hot Melt Extrusion

open access: yesPharmaceutical Fronts, 2019
The purpose of this study was to develop a solid dispersion (SD) by miniaturized hot-melt extrusion (HME) for an insoluble molecule ZL006 which showed potency of increasing leukocytes.
Lijun Zhang   +3 more
doaj   +1 more source

Bio‐inspired nanophotonics: Structural color, chirality, and resonance metasurfaces

open access: yesInfoMat, EarlyView.
A butterfly‐wing‐inspired anisotropic plasmonic flatband resonant metasurface. Insets, photo of the butterfly, Sasakia charonda, and the SEM image of its wing scale (above); the SEM image of the metasurface (below). Abstract The dazzling colors of butterfly wings and hummingbird feathers are not painted with pigments, but crafted by nature's invisible ...
Weihan Liu, Yao Liang, Din Ping Tsai
wiley   +1 more source

Development of an Efficient and Scalable Process for Preparing Timolol N‐Nitrosamine Impurities B, C, E, H, I, J, and Their ADMET Evaluation

open access: yesJournal of Heterocyclic Chemistry, EarlyView.
N‐nitrosamine impurities (B, C, E, H, I, J) of timolol maleate are easily synthesized from diethyl malonate and 3,4‐dichloro‐1,2,5‐thiadiazole. Good yields and precise impurity profiling are made possible by the effective technique, which also ensures pharmaceutical safety and strengthens regulatory compliance.
Kottolla Sai Prasad   +3 more
wiley   +1 more source

Event-related EEG correlations between physically isolated participants [PDF]

open access: yes, 2008
This thesis is an attempt to evaluate findings previously reported in the research literature which have suggested the presence of event-related correlations in electrical brain activity between physically isolated participants.
Kittenis, Marios D.
core   +1 more source

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