Early microglial response to amyloid plaques drives sleep loss in Alzheimer's disease
Abstract INTRODUCTION Sleep disruption is an early feature of Alzheimer's disease (AD), but the cellular mechanisms linking amyloid pathology to sleep loss remain unclear. METHODS Electroencephalography/electromyography (EEG/EMG) recordings, quantitative EEG analysis, and sleep deprivation were performed in APPswe/PSEN1dE9 (APP/PS1) mice at different ...
Nicholas J. Constantino +9 more
wiley +1 more source
Evaluation of sNfL as a Biomarker for Paclitaxel-Induced Peripheral Neurotoxicity Through an Integrated PKPD Model. [PDF]
Ibrahim EIK +13 more
europepmc +1 more source
The extreme event of climate change (CC) has become more crucial, and under the current context of CC during the last decade. The cropping system (CS) approach is more appropriate than a suitable and established package of practices for individual crops, as CS interrelates with other components and resources related to sustainable farming under the ...
Sagar Maitra +9 more
wiley +1 more source
Pharmacokinetic Changes of Ceftazidime-Avibactam with Veno-Arterial Extracorporeal Membrane Oxygenation in a Critically Ill Patient with Severe Renal Impairment: A Case Report. [PDF]
Shen Z, Qin H, Li Q, Mao X.
europepmc +1 more source
This review provides a comprehensive summary of monoamine neurotransmitter analysis by capillary electrophoresis with amperometric detection. Fundamental principles of amperometric detection, electrode positioning strategies, and approaches to high‐voltage decoupling are described, followed by a critical comparison of electrode materials, selection of ...
Petr Kubáň +3 more
wiley +1 more source
Gabapentin CNS exposure and analgesic response are modulated by OCT2 genotype in patients with chronic neuropathic pain. [PDF]
Zhou L +7 more
europepmc +1 more source
A simple and reliable method for the qualitative and quantitative analysis of nano- and microplastics in organs for controlled preclinical studies. [PDF]
Jeon S +6 more
europepmc +1 more source
Antimicrobial peptides isolated from probiotics as an alternative to antibiotics against <i>Salmonella</i> infection. [PDF]
Bhandari M +4 more
europepmc +1 more source
This paper highlights the role of groundwater inputs to the river system during flood events in diluting suspended sediment concentration, in two small badland catchments with contrasting vegetation cover. The findings underline the importance of isolating the surface runoff component to better understand and prioritise hydrosedimentary processes ...
Ophélie Fischer +4 more
wiley +1 more source
CVE-assisted Co<sub>3</sub>O<sub>4</sub> nanoparticle-coated optical fiber sensor for acetone detection. [PDF]
Sahu B +8 more
europepmc +1 more source

