Results 191 to 200 of about 902,749 (382)
Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10
Advanced Science, EarlyView.Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract
Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu +16 morewiley +1 more sourceGlobal Tumor RNA Expression in Early Establishment of Experimental Tumor Growth and Related Angiogenesis following Cox-Inhibition Evaluated by Microarray Analysis
Cancer Informatics, 2007 Altered expression of COX-2 and overproduction of prostaglandins, particularly prostaglandin E2, are common in malignant tumors. Consequently, non-steroidal anti-inflammatory drugs (NSAIDs) attenuate tumor net growth, tumor related cachexia, improve ...Kent Lundholm, Christina Lönnroth, Wenhua Wang, Marianne Andersson, Hans Axelsson +4 moredoaj Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies.
American Journal of Human Genetics, 2010 David T. Miller, M. Adam, M. Adam, S. Aradhya, L. Biesecker, A. Brothman, N. Carter, D. Church, J. Crolla, E. Eichler, C. Epstein, W. Faucett, L. Feuk, J. Friedman, A. Hamosh, L. Jackson, E. B. Kaminsky, K. Kok, I. Krantz, R. Kuhn, Charles Lee, J. Ostell, C. Rosenberg, S. Scherer, N. Spinner, D. Stavropoulos, J. Tepperberg, E. Thorland, J. Vermeesch, D. Waggoner, M. Watson, C. Martin, D. Ledbetter +32 moresemanticscholar +1 more sourceSkullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer
Advanced Science, EarlyView.Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.Jing Zhao, Yu‐Bo Ma, Rui‐Hong Xia, Zheng‐Chen Jiang, Ying Zhou, Ya‐Nan Wang, Meng‐Yan Yang, Jing‐Jie Dai, Tao Zhu, Li‐Bin Pan, Li Yuan +10 morewiley +1 more sourceDKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer
Advanced Science, EarlyView.In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger +20 morewiley +1 more source