Results 191 to 200 of about 515,000 (271)

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source

Biofunctionalized patterned platform as microarray biochip to supervise delivery and expression of pDNA nanolipoplexes in stem cells via mechanotransduction. [PDF]

J Nanobiotechnology
Shen M, Hou Y, Xu S, Tan J, Zhou H, Miao Q, Zhang W, Chen Y, Wang N, Wang Y.   +9 more
europepmc   +1 more source

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Cancer classification in high dimensional microarray gene expressions by feature selection using eagle prey optimization. [PDF]

Front Genet
Dhamercherla S, Reddy Edla D, Dara S.
europepmc   +1 more source

PLXDC1+ Tumor‐Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study uncovers the activation, heterogeneity, and regulatory roles of pancreatic stellate cells (PSCs) at single‐cell and spatial levels. It further identifies PLXDC1+ PSCs near aggressive LRRC15+ cancer‐associated myofibroblasts and SPP1+ macrophages, forming a desmoplastic and immunosuppressive tumor niche that promotes CD8+ T cell exhaustion ...
Yanhua Du, Yizhou Zhao, Judong Li, Jiaxin Wang, Shenglan You, Yao Zhang, Li Zhang, Jihong Yang, Hamid Alinejad‐Rokny, Shujie Cheng, Chenghao Shao, Duowu Zou, Youqiong Ye   +12 more
wiley   +1 more source

Generalizability of machine learning models for diabetes detection a study with nordic islet transplant and PIMA datasets. [PDF]

Sci Rep
Chellappan D, Rajaguru H.
europepmc   +1 more source

Multimodal Nanoplasmonic and Fluorescence Imaging for Simultaneous Monitoring of Single‐Cell Secretory and Intracellular Dynamics

Advanced Science, EarlyView.
This study leverages the complementary advantages of label‐free nanoplasmonic biosensing and multichannel fluorescence microscopy to develop a multimodal imaging system for real‐time, spatiotemporal monitoring of cellular activities at the single‐cell level.
Saeid Ansaryan, Yung‐Cheng Chiang, Yen‐Cheng Liu, Patrick Reichenbach, Melita Irving, Hatice Altug   +5 more
wiley   +1 more source

Candidate Biomarkers Associated With Circulating Tumor Cell Status in Metastatic Colorectal Cancer. [PDF]

J Clin Lab Anal
Doğan B, Pirim D, Işık Ö, Evrensel T.   +3 more
europepmc   +1 more source

MISP Suppresses Ferroptosis via MST1/2 Kinases to Facilitate YAP Activation in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
This study explores the role of Mitotic Spindle Positioning (MISP) as a key inhibitor of ferroptosis in non‐small cell lung cancer (NSCLC). MISP upregulation in NSCLC tissues leads to ferroptosis resistance, promoting cell proliferation. Mechanistically, MISP suppresses Hippo signaling via MST1/2 kinases, activating YAP and enhancing SLC7A11 expression,
Fuquan Zhang, Bingtao Huang, Yiming Xu, Guohong Cao, Mingjing Shen, Changmin Liu, Judong Luo   +6 more
wiley   +1 more source

Heterogeneity-preserving discriminative feature selection for disease-specific subtype discovery. [PDF]

Nat Commun
M A Basher AR, Hallinan C, Lee K.
europepmc   +1 more source