Results 61 to 70 of about 23,939,903 (293)

Identification and Characterization of Differentially Expressed MicroRNAs in Benign Prostatic Hyperplasia

Cancer Reports
Objectives The primary aim of this research is to identify and describe the distinct patterns of microRNAs (miRNAs) that are unusually expressed in benign prostatic hyperplasia (BPH) tissues compared to normal prostatic tissues. Materials and Methods The
Lingmin Song, Xue Wang, Gang Wang, Liwei Zheng, Zhansong Zhou   +4 more
doaj   +1 more source

Aberrations of the number of copies (CNA) in the genome of luminal B breast tumor

Бюллетень сибирской медицины, 2020
Aim. To describe the CNA (Copy Number Aberration) landscape of luminal B breast tumor before treatment.Materials and methods. The study included 100 patients with breast cancer (BC) of luminal B subtype for which a biopsy of the tumor material was ...
M. K. Ibragimova, M. M. Tsyganov, E. M. Slonimskaya, N. V. Litviakov   +3 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Identification of Key Genes and Pathways in Post-traumatic Stress Disorder Using Microarray Analysis

Frontiers in Psychology, 2019
Introduction: Post-traumatic stress disorder (PTSD) is characterized by impaired fear extinction, excessive anxiety, and depression. However, the potential pathogenesis and cause of PTSD are not fully understood.
Yaoyao Bian, Lili Yang, Lili Yang, Min Zhao, Zhengjun Li, Yuying Xu, Guilian Zhou, Wenlin Li, Li Zeng, Li Zeng   +9 more
doaj   +1 more source

Microarray Analysis for Transcriptomic Profiling of Myocardium in Patients with Fatal Myocardial Infarction

Biomedicines, 2023
Transcriptomic evidence from human myocardium in myocardial infarction (MI) is still not sufficient. Thus, there is a need for studies on human cardiac samples in relation to the clinical data of patients.
Vyacheslav Ryabov, Aleksandra Gombozhapova, Nikolai Litviakov, Marina Ibragimova, Matvey Tsyganov, Yulia Rogovskaya, Julia Kzhyshkowska   +6 more
doaj   +1 more source

Serendipitous discoveries in microarray analysis [PDF]

BMC Bioinformatics, 2010
Background Scientists are capable of performing very large scale gene expression experiments with current microarray technologies. In order to find significance in the expression data, it is common to use clustering algorithms to group genes with similar expression patterns. Clusters will often contain related genes, such as co-regulated genes or genes
Sally R. Ellingson, Charles A. Phillips, Randy Glenn, Douglas Swanson, Thomas Ha, Daniel Goldowitz, Michael A. Langston   +6 more
openaire   +2 more sources

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Preparation and Analysis of Glycan Microarrays [PDF]

Current Protocols in Protein Science, 2011
AbstractDetermination of the binding specificity of glycan‐binding proteins (GBPs), such as lectins, antibodies, and receptors, has traditionally been difficult and laborious. The advent of glycan microarrays has revolutionized the field of glycobiology by allowing simultaneous screening of a GBP for interactions with a large set of glycans in a single
Jamie, Heimburg-Molinaro, Xuezheng, Song, David F, Smith, Richard D, Cummings   +3 more
openaire   +2 more sources