Results 211 to 220 of about 185,542 (303)

Intranasal Wharton's Jelly‐Derived Mesenchymal Stem Cell Therapy, Alone or in Conjunction With Therapeutic Hypothermia, Alleviates Neonatal Hypoxic‐Ischemic Brain Injury in Mice

Annals of Neurology, EarlyView.
This study demonstrates that intranasal Wharton's jelly‐derived mesenchymal stem cell (WJ‐MSC) administration at 3 or 10 days post‐insult reduced the lesion size and sensorimotor impairment following neonatal hypoxic‐ischemic (HI) brain injury in mice. WJ‐MSCs expressed receptors for HI‐upregulated chemokines and migrated from the nasal cavity into the
Caroline G. M. de Theije, Sara T. De Palma, Josine E. G. Vaes, Katiuscia Dallaglio, Giorgia Volpi, Diego Ardigò, Sabine van Rijt, Frank van Bel, Manon J. N. L. Benders, Cora H. A. Nijboer   +9 more
wiley   +1 more source

Identification of potential hub genes and molecular mechanisms in breast cancer microenvironment: A comprehensive transcriptomics approach. [PDF]

Medicine (Baltimore)
Noman AA, Saba AA, Sayem M, Yasmin T, Nabi AHMN.   +4 more
europepmc   +1 more source

Phenotypic Changes in a Monocyte Cluster with High Interleukin‐1 Beta Expression during Long‐Term Anti‐CD20 Therapy

Annals of Neurology, EarlyView.
Graphical abstract illustrating the study design, experimental workflow, and key findings from single‐cell profiling of peripheral mononuclear cells in multiple sclerosis patients undergoing anti‐CD20 therapy, revealing disease‐ and treatment‐associated immune signatures.
Mie Waede, Christina Kingo, Karina Damsbo, Maiken Uhrbrand Joergensen, Mhaned Oubounyt, Morten Gjerstorff, Mads Thomassen, Jan Baumbach, Jesper B. Moeller, Maria L. Elkjaer, Zsolt Illes   +10 more
wiley   +1 more source

What the VAF? A guide to the interpretation of variant allele fraction, percent mosaicism, and copy number in cancer. [PDF]

Mol Cytogenet
Smith AC, Tsui H, Usta S, Capo-Chichi JM.   +3 more
europepmc   +1 more source

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

A High-Throughput ImmunoHistoFluorescence (IHF) Method for Sub-Nuclear Protein Analysis in Tissue. [PDF]

Cells
Oxe KC, Rohrberg KS, Lassen U, Larsen DH.   +3 more
europepmc   +1 more source

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

Advanced NanoBiomed Research, EarlyView.
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong   +7 more
wiley   +1 more source

An interpretable and adaptive autoencoder for efficient tissue deconvolution. [PDF]

Nucleic Acids Res
de la Fuente J, Legarra-Marcos N, Diaz-Mazkiaran A, Serrano G, Marín-Goñi I, Sendin MB, Osta AG, Kalari KR, Fernandez-Granda C, Ochoa I, Hernaez M.   +10 more
europepmc   +1 more source

Interactome Profiling of a Lysine Deacetylase Trapping Probe Library Uncovers Crosstalk Between HDAC6 and NF‐κB Signaling

Angewandte Chemie International Edition, EarlyView.
We designed a peptide probe library containing hydroxamic acids based on putative substrate sites of lysine deacetylase HDAC6. Analyzing substrate selectivity and turnover combined with proteomics profiling resulted in identification of novel HDAC6 interaction partners, such as components of the transcription factor NF‐κB.
Julian Seidel, Caroline Schönfeld, Julia Sindlinger, Jürgen Eirich, Sören Kirchgäßner, Nina Kreienkamp, Klaus Schulze‐Osthoff, Iris Finkemeier, Stephan Hailfinger, Dirk Schwarzer   +9 more
wiley   +1 more source

Derivative Complex Small Supernumerary Marker Chromosomes (sSMC) Involving Chromosomes 2 and 15-A Novel Report. [PDF]

Clin Case Rep
Alayed Y, Mushiba A, Tashkandi S, Almashham Y, Alsaidi K, Albohigan A, Jamhawi A, Alkheilewi M, Alotaibi M.   +8 more
europepmc   +1 more source