Results 21 to 30 of about 91,659 (259)

New array approaches to explore single cells genomes

Frontiers in Genetics, 2012
Microarray analysis enables the genome wide detection of copy number variations and the investigation of chromosomal instability. Whereas array techniques have been well established for the analysis of unamplified DNA derived from many cells, it has been
Evelyne eVanneste, Lilach eBittman, Niels eVan der Aa, Thierry eVoet, Joris Robert Vermeesch   +4 more
doaj   +1 more source

Optimization of Cyanine Dye Stability and Analysis of FRET Interaction on DNA Microarrays

Biology, 2016
The application of DNA microarrays for high throughput analysis of genetic regulation is often limited by the fluorophores used as markers. The implementation of multi-scan techniques is limited by the fluorophores’ susceptibility to photobleaching when ...
Marcel von der Haar, Christopher Heuer, Martin Pähler, Kathrin von der Haar, Patrick Lindner, Thomas Scheper, Frank Stahl   +6 more
doaj   +1 more source

Evaluation of the Tissue Microarray Technique for Immunohistochemical Analysis in Rectal Cancer

Archives of Pathology & Laboratory Medicine, 2002
Abstract Background. —Immunohistochemical staining for tumor-associated proteins is widely used for the identification of novel prognostic markers. Recently, a tissue-conserving, high-throughput technique, tissue microarray, has been introduced.
Eva, Fernebro, Michael, Dictor, Pär-Ola, Bendahl, Mårten, Fernö, Mef, Nilbert   +4 more
openaire   +2 more sources

Comprehensive Review of Hybrid Feature Selection Methods for Microarray-Based Cancer Detection

IEEE Access
Microarray data-based cancer detection advances early diagnosis and personalized medicine by utilizing gene expression data to develop comprehensive cancer profiles, measuring thousands of genes simultaneously.
Azka Khoirunnisa, Didit Adytia, Mustafa Mat Deris, Adiwijaya   +3 more
doaj   +1 more source

Comparison of different probe-level analysis techniques for oligonucleotide microarrays

BioTechniques, 2004
Three different software packages for the probe-level analysis of high-density oligonucleotide microarray data were compared using an experiment-derived data set that was validated using real-time PCR. The efficiency with which these three programs could identify true positives in this data set was assessed. In addition, estimates of false-positive and
Barbara Rosati, Frederic Grau, Anneke Kuehler, Samantha Rodriguez, David McKinnon   +4 more
openaire   +3 more sources

Application of chromosome microarray analysis and karyotyping in fetal cardiac abnormalities

Frontiers in Genetics
ObjectiveChromosome microarray analysis (CMA) and karyotyping are two important genetic testing techniques used in prenatal diagnosis. This study aims to evaluate the value of chromosome microarray analysis and karyotyping in the diagnosis of fetal ...
Yun Guo, Xiaoqin Xin, Linju Zhou, Jungao Huang   +3 more
doaj   +1 more source

Pro-MAP: a robust pipeline for the pre-processing of single channel protein microarray data

BMC Bioinformatics, 2022
Background The central role of proteins in diseases has made them increasingly attractive as therapeutic targets and indicators of cellular processes. Protein microarrays are emerging as an important means of characterising protein activity.
Metoboroghene Oluwaseyi Mowoe, Shaun Garnett, Katherine Lennard, Jade Talbot, Paul Townsend, Eduard Jonas, Jonathan Michael Blackburn   +6 more
doaj   +1 more source

Analysis with respect to instrumental variables for the exploration of microarray data structures

BMC Bioinformatics, 2006
Background Evaluating the importance of the different sources of variations is essential in microarray data experiments. Complex experimental designs generally include various factors structuring the data which should be taken into account. The objective
Schwager Joseph, Wiegand Jan, Facompré Michaël, Baty Florent, Brutsche Martin H   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Clustering column-mean quantile median: a new methodology for imputing missing data

Journal of Engineering and Applied Science, 2022
DNA microarray data sets have been widely explored and used to analyze data without any previous biological background. However, analyzing them becomes challenging if data are missing.
Nourhan Yehia, Manal Abdel Wahed, Mai Said Mabrouk   +2 more
doaj   +1 more source