Results 71 to 80 of about 185,542 (303)

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Robust gene selection methods using weighting schemes for microarray data analysis

BMC Bioinformatics, 2017
Background A common task in microarray data analysis is to identify informative genes that are differentially expressed between two different states. Owing to the high-dimensional nature of microarray data, identification of significant genes has been ...
Suyeon Kang, Jongwoo Song
doaj   +1 more source

Recovering Sparse Signals Using Sparse Measurement Matrices in Compressed DNA Microarrays [PDF]

, 2008
Microarrays (DNA, protein, etc.) are massively parallel affinity-based biosensors capable of detecting and quantifying a large number of different genomic particles simultaneously.
Hassibi, Babak, Misra, Sidhant, Parvaresh, Farzad, Vikalo, Haris   +3 more
core   +2 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Application of COMPOCHIP Microarray to Investigate the Bacterial Communities of Different Composts [PDF]

, 2009
A microarray spotted with 369 different 16S rRNA gene probes specific to microorganisms involved in the degradation process of organic waste during composting was developed. The microarray was tested with pure cultures, and of the 30,258 individual probe-
A Alfreider, A Loy, A Loy, BEE Buchholz-Cleven, Brigitte A. Knapp, CJF Braak ter, D Guschin, D-Y Lee, DA Stahl, DM Barrett, EW Alm, F Schwieger, F Wintzingerode von, G Muyzer, G Taroncher-Oldenburg, G Varani, H Daims, H Sanguin, H Urakawa, HAJ Hoitink, HAJ Hoitink, HAJ Hoitink, Heribert Insam, HM Dionisi, IH Franke-Whittle, IH Franke-Whittle, Ingrid H. Franke-Whittle, J Peplies, J Ryckeboer, Jacques Fuchs, JG Fuchs, K Nakasaki, K-H Kim, KJ Breslauer, L Bodrossy, L Bodrossy, L Ludwig, M Blanc, M Danon, M Hogardt, MA Elorrieta, MT Suzuki, N Stralis-Pavese, P Legendre, P Schloss, PM Dees, R Amann, Ruediger Kaufmann, S Haruta, SF Altschul, SM Tiquia, SM Tiquia, T Beffa, W-T Liu, Y Koizumi   +54 more
core   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

DNA microarray technology in medical diagnostics

Zdravniški Vestnik, 2007
Background: DNA microarray technology opened a completely new venue in the biomedical research. By allowing to follow the expression of thousands of genes in a single experiment (ideally we can follow the expression of the entire genome), the microarray ...
Damjana Rozman, Peter Juvan
doaj  

Triple-target microarray experiments: a novel experimental strategy

BMC Genomics, 2004
Background High-throughput, parallel gene expression analysis by means of microarray technology has become a widely used technique in recent years. There are currently two main dye-labelling strategies for microarray studies based on custom-spotted cDNA ...
Cooke Howard J, Roy Douglas, Costa Yael, Forster Thorsten, Maratou Klio   +4 more
doaj   +1 more source

Transformation Based Tri-Level Feature Selection Approach Using Wavelets and Swarm Computing for Prostate Cancer Classification

IEEE Access, 2020
Prostate Cancer is a cancer that occurs in the prostate- a small walnut shaped gland in men. This gland helps in the production of seminal fluid which is used to nourish and transport the sperm.
Sunil Kumar Prabhakar, Seong-Whan Lee
doaj   +1 more source