Results 1 to 10 of about 30,368 (210)

Discovery of New Microbial Collagenase Inhibitors [PDF]

Life, 2022
Bacterial virulence factors are mediating bacterial pathogenesis and infectivity. Collagenases are virulence factors secreted by several bacterial stains, such as Clostridium, Bacillus, Vibrio and Pseudomonas.
Georgiana Nitulescu, Dragos Paul Mihai, Anca Zanfirescu, Miruna Silvia Stan, Daniela Gradinaru, George Mihai Nitulescu   +5 more
doaj   +6 more sources

Safety evaluation of the food enzyme microbial collagenase from the genetically modified Streptomyces violaceoruber strain pCol [PDF]

EFSA Journal
The food enzyme microbial collagenase (EC 3.4.24.3) is produced with the genetically modified Streptomyces violaceoruber strain pCol by Nagase (Europa) GmbH. The genetic modifications do not give rise to safety concerns.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Lieve Herman, Yrjö Roos, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Cristina Fernàndez‐Fraguas, Silvia Peluso, Elsa Nielsen, Karin Nørby, Giulio diPiazza, Laura Sanmartín Cabo, Yi Liu, Andrew Chesson   +29 more
doaj   +9 more sources

Candidates for Repurposing as Anti-Virulence Agents Based on the Structural Profile Analysis of Microbial Collagenase Inhibitors [PDF]

Pharmaceutics, 2021
The pharmacological inhibition of the bacterial collagenases (BC) enzymes is considered a promising strategy to block the virulence of the bacteria without targeting the selection mechanism leading to drug resistance.
Georgiana Nitulescu, George Mihai Nitulescu, Anca Zanfirescu, Dragos Paul Mihai, Daniela Gradinaru   +4 more
doaj   +7 more sources

Microbial Exploitation of Feather Wastes for Sustainable Production of Keratinase and Collagenase Enzymes by Didymella keratinophila AUMC 15399 in Submerged Fermentation [PDF]

Fermentation, 2023
A distinctive isolate was discovered and visually recognized as a member of the genus Didymella during a routine examination of Coelomycetes isolated from diverse fruit juices.
Osama Abdel-Hafeez Mohamed Al-Bedak, Ahmed Mohamed Moharram, Nemmat Abdel-Gawad Hussein, Doaa Mohamed Taha, Steven L. Stephenson, Fuad Ameen   +5 more
doaj   +3 more sources

The action of microbial collagenases in dentinal matrix degradation in root caries and potential strategies for its management: a comprehensive state-of-the-art review [PDF]

Journal of Applied Oral Science
Conventional views associate microbial biofilm with demineralization in root caries (RC) onset, while research on their collagenases role in the breakdown of collagen matrix has been sporadically developed, primarily in vitro. Recent discoveries, however,
Cecília de Brito BARBOSA, Isabela MONICI SILVA, Naile DAME-TEIXEIRA   +2 more
doaj   +5 more sources

Differences in the degradation of native collagen by two microbial collagenases [PDF]

Biochemical Journal, 1979
The early stages of degradation of native collagen by two bacterial collagenases were studied by electron microscopy and by automatic Edman degradation. The purified collagenase from Clostridium histolyticum was shown to cleave native collagen at several sites, but not progressively from the N-terminus, as had been previously suggested. The homogeneous
A. Lecroisey, B. Keil
openalex   +4 more sources

Microbial bioremediation of feather wastes and eco-friendly production of keratinase and collagenase enzymes by Didymella keratinophila, the first-recorded fungus from Assiut, Egypt [PDF]

, 2022
Abstract During a routine examination of Coelomycetes isolated from various fruit juices in Assiut Governorate, Egypt, a unique isolate was discovered and visually identified as a Didymella member. The fungus was confirmed as Didymella keratinophila based on sequencing of the internal transcribed spacer (ITS), since it had 100% identity to the ...
Osama A.M. Al-Bedak, A. M. Moharram, Nemmat A. Hussein, Doaa Mohamed Taha   +3 more
openalex   +2 more sources

Hydrolysis of the Leu-Gly bond of phenylazobenzyl-oxycarbonyl-l-Pro-l-Leu-Gly-l-Pro-D-Arg (a substrate of microbial collagenases) by treponemes isolated from the subgingival plaque of periodontitis patients [PDF]

Current Microbiology, 1990
Cell extracts prepared from several oral treponemes isolated from the subgingival plaque of periodontitis patients showed high enzyme activity toward phenylazobenzyl-oxycarbonyl-l-prolyl-l-leucylglycyl-l-prolyl-d-arginine (a compound used as a substrate for microbial collagenases).
Kauko K. Mäkinen, Salam A. Syed, Sérgio Luiz de Souza Salvador, Pirkko‐Liisa Mäkinen   +3 more
openalex   +4 more sources

An overview on therapeutic potential and various applications of microbial collagenases

Journal of Microbiology and Biotechnology Research, 2017
Collagen is the most widely distributed class of proteins in the human body. Monomers of collagen are constantly being synthesized and degraded throughout the development of a healthy individual to adulthood. The collagenase subfamily found in human matrix (metalloproteinases), are capable of hydrolyzing native collagen under physiological conditions ...
Wamik Azmi, Shikha Chauhan, Manisha Gautam   +2 more
openalex   +2 more sources

Microbial collagenases: challenges and prospects in production and potential applications in food and nutrition

RSC Advances, 2016
Microbial collagenases are promising enzymes in view of their extensive industrial and biological applications.
Gaurav Kumar Pal, Suresh PV
openalex   +2 more sources