Results 1 to 10 of about 29,219 (208)

Discovery of New Microbial Collagenase Inhibitors [PDF]

Life, 2022
Bacterial virulence factors are mediating bacterial pathogenesis and infectivity. Collagenases are virulence factors secreted by several bacterial stains, such as Clostridium, Bacillus, Vibrio and Pseudomonas.
Georgiana Nitulescu, Dragos Paul Mihai, Anca Zanfirescu, Miruna Silvia Stan, Daniela Gradinaru, George Mihai Nitulescu   +5 more
doaj   +4 more sources

Candidates for Repurposing as Anti-Virulence Agents Based on the Structural Profile Analysis of Microbial Collagenase Inhibitors [PDF]

Pharmaceutics, 2021
The pharmacological inhibition of the bacterial collagenases (BC) enzymes is considered a promising strategy to block the virulence of the bacteria without targeting the selection mechanism leading to drug resistance.
Georgiana Nitulescu, George Mihai Nitulescu, Anca Zanfirescu, Dragos Paul Mihai, Daniela Gradinaru   +4 more
doaj   +5 more sources

Safety evaluation of the food enzyme microbial collagenase from the genetically modified Streptomyces violaceoruber strain pCol [PDF]

EFSA Journal
The food enzyme microbial collagenase (EC 3.4.24.3) is produced with the genetically modified Streptomyces violaceoruber strain pCol by Nagase (Europa) GmbH. The genetic modifications do not give rise to safety concerns.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Lieve Herman, Yrjö Roos, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Cristina Fernàndez‐Fraguas, Silvia Peluso, Elsa Nielsen, Karin Nørby, Giulio diPiazza, Laura Sanmartín Cabo, Yi Liu, Andrew Chesson   +29 more
doaj   +7 more sources

Gene expression of bacterial collagenolytic proteases in root caries [PDF]

Journal of Oral Microbiology, 2018
Objective: It is unknown whether bacteria play a role in the collagen matrix degradation that occurs during caries progression. Our aim was to characterize the expression level of genes involved in bacterial collagenolytic proteases in root biofilms with
Nailê Damé-Teixeira, Clarissa Cavalcanti Fatturi Parolo, Marisa Maltz, Ariel Goulart Rup, Deirdre Ann Devine, Thuy Do   +5 more
doaj   +2 more sources

Microbial Exploitation of Feather Wastes for Sustainable Production of Keratinase and Collagenase Enzymes by Didymella keratinophila AUMC 15399 in Submerged Fermentation

Fermentation, 2023
A distinctive isolate was discovered and visually recognized as a member of the genus Didymella during a routine examination of Coelomycetes isolated from diverse fruit juices.
Osama Abdel-Hafeez Mohamed Al-Bedak, Ahmed Mohamed Moharram, Nemmat Abdel-Gawad Hussein, Doaa Mohamed Taha, Steven L. Stephenson, Fuad Ameen   +5 more
doaj   +2 more sources

The action of microbial collagenases in dentinal matrix degradation in root caries and potential strategies for its management: a comprehensive state-of-the-art review [PDF]

Journal of Applied Oral Science
Conventional views associate microbial biofilm with demineralization in root caries (RC) onset, while research on their collagenases role in the breakdown of collagen matrix has been sporadically developed, primarily in vitro. Recent discoveries, however,
Cecília de Brito BARBOSA, Isabela MONICI SILVA, Naile DAME-TEIXEIRA   +2 more
doaj   +3 more sources

Anti-aging potential of Monascus purpureus pigments in skin care [PDF]

Pharmaceutical Biology
Context Natural pigments derived from microbial sources are garnering increasing attention owing to their multifunctional roles in cosmetic and biomedical applications.Objective We investigated the antioxidant and biological activities of biocolor ...
Rittipun Rungruang, Tasanee Panichakul, Napassorn Peasura, Sasithorn Kongruang   +3 more
doaj   +2 more sources

Unlocking the Potential of Collagenases: Structures, Functions, and Emerging Therapeutic Horizons [PDF]

BioDesign Research
Collagenases, a class of enzymes that are specifically responsible for collagen degradation, have garnered substantial attention because of their pivotal roles in tissue repair, remodeling, and medical interventions.
Zhen-Zhen Wang, Kang Wang, Ling-Feng Xu, Chang Su, Jin-Song Gong, Jin-Song Shi, Xu-Dong Ma, Nan Xie, Jian-Ying Qian   +8 more
doaj   +2 more sources

CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN’S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UP [PDF]

Acta Ortopédica Brasileira, 2023
Objectives: This study aims to report our experience with Clostridium Histolyticum collagenase (CCH) to support the importance of its clinical use and assess its clinical efficacy, complications, and recurrences.
Morena Anna Basso, Alessio Bernasconi, Giovanni Balato, Andrea Cozzolino, Giulia Famiglietti, Francesco Smeraglia   +5 more
doaj   +1 more source

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies

Frontiers in Cellular and Infection Microbiology, 2023
Introduction and aimThe presence of host collagenases in the degradation of the protein matrix at later stages of carious dentin lesions development, as well as the potential involvement of bacterial collagenases, have been suggested but lack conclusive ...
Cecília de Brito Barbosa, Isabela Monici Silva, Jéssica Alves de Cena, Cristine Miron Stefani, Naile Dame-Teixeira   +4 more
doaj   +1 more source