Results 131 to 140 of about 364,417 (317)

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Paraboremia selaginellae enhances Salvia miltiorrhiza growth and cadmium tolerance via modulating root architecture and cadmium speciation in contaminated environments

Frontiers in Plant Science
IntroductionDark septate endophytes (DSEs) commonly colonize plant roots in heavy metal-polluted habitats, but little is known about the potential mechanisms driving medicinal plants to adapt to heavy metal-polluted environments.
Yuli Lin, Yuli Lin, Zhenzhou Wang, Zhenzhou Wang, Wenjing Chen, Wenjing Chen, Yunfeng Liu, Yunfeng Liu, Xia Li, Xia Li, Hongliang Tang, Hongliang Tang, Xueli He, Xueli He   +13 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Temperature-driven metabolic adaptation in thermophilic microbial communities of Western Sichuan hot springs

BMC Microbiology
Background Understanding microbial adaptation to extreme environments remains a key challenge in microbial ecology. Geothermal hot springs, characterized by temperature gradients and varying geochemical conditions, represent valuable natural laboratories
Sainan Luo, Xiuzhen Chen, Shunchao Guo, Songnian Hu, Zhiyang Dong, Jianing Geng   +5 more
doaj   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Genome-Wide Landscape of Position Effect Variegation in Pichia pastoris

Journal of Fungi
Exogenous genes are generally expressed by integration into the chromosomes of Pichia pastoris. However, systematic studies on the chromosomal position effect are lacking, and locations that are conducive to the high expression of foreign genes are ...
Xueyan Yao, Baosong Chen, Zhihui Zhang, Wenyan Gao, Qian Zhang, Yongpeng Yao, Yuanyuan Pan, Gang Liu   +7 more
doaj   +1 more source

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

Advanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi, Hannah S. Leese, Benjamin Metcalfe, Mirella Di Lorenzo   +3 more
wiley   +1 more source

THE MICROBIAL DIVERSITY PRESENT IN A TROPICAL, CIRCUMNEUTRAL IRON SPRING IN GRENADA [PDF]

, 2009
Microbial evolution has allowed for microbial adaptation to many diverse and harsh environments. As a result, microbial diversity varies spatially, depending on the environmental pressures that are limiting.
Ravindra Naraine; 1,2St. George’s University, Thomas Smith; Southern Arkansas University, Karsten Pedersen; Gothenburg University, Lotta Hallbeck; Microbial Analytics Sweden AB, Sweden, Sara Jägevall; Microbial Analytics Sweden AB, Sweden, Svetlana V Kotelnikova; St. George’s University   +5 more
core  

Integrative analysis of fungal communities in three types of Baijiu Daqu using third-generation sequencing and culturomics

Frontiers in Microbiology
Daqu, the core fermentation starter for Chinese Baijiu, harbors intricate and functionally important fungal communities. To comprehensively characterize its biodiversity, we employed an integrated approach combining third-generation amplicon sequencing ...
Yu-Hua Wei, Yu-Hua Wei, Da-Yong Han, Liang Song, Liang-Chen Guo, Liang-Chen Guo, Mei Bai, Mei Bai, Pei-Jie Han, Hai-Yan Zhu, Zhang Wen, Zhang Wen   +11 more
doaj   +1 more source