Results 181 to 190 of about 190,830 (306)

Microbes and medicines: interrelationships between pharmaceuticals and the gut microbiome. [PDF]

Gut Microbes
Al-Btoosh S, Donnelly RF, Kelly SA.
europepmc   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Phage therapy and the microbiome in hematologic malignancies: opportunities, mechanisms, and early evidence. [PDF]

J Cancer Res Clin Oncol
Zhang J, Liu J, Bayani A.
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Biofilms: from the cradle of life to life support. [PDF]

NPJ Biofilms Microbiomes
Baxter KJ, Sas E, Clark KB, Walsh M, Pradeep N, Batool A, Naney C, Vargas Cruz MA, Kennerdale N, Das K, Shi Z, Kelam A, Verma V, Simões MF, Neefs D, Ravichandran V, Tirumalai MR, Barcenilla BB, Macori G, Gonzalez E, Sikes B, Karouia F, Brereton NJB.   +22 more
europepmc   +1 more source

DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation

Advanced Science, EarlyView.
DR5 knockout exhibits a thinner colonic mucus layer, leading to mild dysbiosis, increased susceptibility to Citrobacter rodentium invasion, and exacerbated epithelial injury. Mechanistically, DR5 binds transcription factor TBP, which regulates the expression of gene Best2 via its promoter.
Ying Wang, Xinyun Li, Yong Wang, Chuhe Yang, Xiaopei Gao, Ke Zhu, Yihang Ren, Jingxin Li, Chuanyong Liu, Bing Xue   +9 more
wiley   +1 more source

ARKbase: Antimicrobial Resistance Knowledgebase1.0. [PDF]

Nucleic Acids Res
Gambhir S, Pandey S, Bajetha H, Kaur J, Das A, Pranavathiyani G, Aggarwal R, Maity U, Dange S, Singh V, Zarkar M, Sankhdher R, Singh B, Seth S, Bhardwaj A.   +14 more
europepmc   +1 more source

Microbial Drug Resistance

, 2008
Cristiana Maria Costa Nascimento de Carvalho, Ticiana Goyanna Lyra, Noraney N. Alves, Renilza M. Caldas, Maria Goreth Barberino, Cristiana Maria Costa Nascimento de Carvalho, Ticiana Goyanna Lyra, Noraney N. Alves, Renilza M. Caldas, Maria Goreth Barberino   +9 more
openalex   +1 more source

Precise Construction of an Antimicrobial Peptide Targeting Bacterial Cell Membranes Derived From Natural Peptides

Advanced Science, EarlyView.
An AMP (P 3‐3R‐8I) based on natural peptides, which can target bacterial cell membranes, was precisely constructed via amino acid mutation. P 3‐3R‐8I exhibits antibacterial capability which could be attributed to the ability of P 3‐3R‐8I to quickly penetrate bacterial cell membranes and then to bind to bacterial DNA.
Jiaqi Huang, Bohao Liu, Xingzhuo Zhu, Deqian Qiao, Sizhe Chen, Xiaoyan Zeng, Qingqing Yang, Zihuan Wei, Yinjuan Huang, Jizhao Wang, Guangjian Zhang, Qiuyu Gong   +11 more
wiley   +1 more source

Cell-to-Cell and Patient-to-Patient Variability in Antimicrobial Resistance. [PDF]

Microorganisms
Huang X, Huang J, Zhong CC, Wong MCS.
europepmc   +1 more source