Results 91 to 100 of about 3,295,358 (263)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Grappling with Proteus: Population level approaches to understanding microbial diversity

Frontiers in Microbiology, 2012
The emerging fields of microbial population genetics and genomics provide an avenue to study the ecological rules that govern how communities form, function, and evolve.
Mallory J. Choudoir, Ashley N. Campbell, Daniel H. Buckley   +2 more
doaj   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Comparative Genomics of Lactobacillus crispatus from the Gut and Vagina Reveals Genetic Diversity and Lifestyle Adaptation

, 2020
Lactobacillus crispatus colonizes the human feces, human vagina, and the crops and ceca of chicken. To explore the genetic characteristics and evolutionary relationships of L. crispatus isolated from different niches, we selected 37 strains isolated from
Paul Ross, Qiuxiang Zhang, Hao Zhang, Wei Chen, Lili Zhang, Jianxin Zhao   +5 more
core   +1 more source

The value of avian genomics to the conservation of wildlife [PDF]

, 2009
Background: Genomic studies in non-domestic avian models, such as the California condor and white-throated sparrow, can lead to more comprehensive conservation plans and provide clues for understanding mechanisms affecting genetic variation, adaptation ...
Hickenbotham, Matthew T, Mardis, Elaine R., Dandekar, Sugandha, Modi, William S, Modi, William S., Jones, Kenneth C., Papp, Jeanette C, Mardis, Elaine R, Glasscock, Jarret, Houck, Marlys L, Green, Eric D, Chemnick, Leona G., Otten, Christie A, Stremel Mork, Emily M., Green, Eric D., Chemnick, Leona G, Stremel Mork, Emily M, Papp, Jeanette C., Romanov, Michael N, Magrini, Vincent, Ryder, Oliver A, Hickenbotham, Matthew T., NISC Comparative Sequencing Program,, Otten, Christie A., Tuttle, Elaina M., Tuttle, Elaina M, Houck, Marlys L., Korody, Marisa L, Renner, Tanya, Jones, Kenneth C, Da, Yang, McGrath, Sean, Korody, Marisa L., Ryder, Oliver A.   +33 more
core   +3 more sources

The effects of extremes of pH on the growth and transcriptomic profiles of three haloarchaea [v2; ref status: indexed, http://f1000r.es/48e]

F1000Research, 2014
The halophilic archaea (haloarchaea) live in saline environments, which are found across the globe.  In addition to salinity, these niches can be quite dynamic and experience extreme conditions such as low oxygen content, radiation (gamma and UV), pH and
Aida Moran-Reyna, James A. Coker
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Investigating the Physiological and Metabolic Requirements of the Tramway Ridge Microbial Community, Mt Erebus, Antarctica [PDF]

, 2012
Mount Erebus is the most active volcano on the Antarctic continent, and has the most geographically and physically isolated geothermal soil on Earth. It is exposed to some of the most extreme environmental conditions on the planet.
Vickers, Chelsea Joy
core  

Impact of timely vaccination and genomic surveillance on controlling consecutive waves of SARS-CoV-2 variants

Scientific Reports
During the global COVID-19 pandemic, different SARS-CoV-2 variants of concern (VOCs) emerged, causing massive transmission waves that affected infection outcomes, economies and public health.
Cecilia Salazar, Nídia S. Trovão, Ignacio Ferrés, Alicia Costábile, Mercedes Paz, Paula Perbolianachis, Ana Moller, Viviana Bortagaray, Rodney Colina, Natalia Rego, Tamara Fernandez-Calero, Lucia Spangenberg, Bernardina Rivera, Martina Alonso, Matías Maidana, Interinstitutional Working Group, Gregorio Iraola, Gonzalo Moratorio, Pilar Moreno   +18 more
doaj   +1 more source

An evolutionarily significant unicellular strategy in response to starvation in Dictyostelium social amoebae [v2; ref status: indexed, http://f1000r.es/4kb]

F1000Research, 2014
The social amoeba Dictyostelium discoideum is widely studied for its multicellular development program as a response to starvation. Aggregates of up to 106 cells form fruiting bodies containing (i) dormant spores (~80%) that can persist for months in the
Darja Dubravcic, Minus van Baalen, Clément Nizak   +2 more
doaj   +1 more source