Results 51 to 60 of about 860,622 (247)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

SARS-CoV-2 Monitoring in Wastewater Reveals Novel Variants and Biomarkers of Infection

Viruses, 2022
Wastewater-based epidemiology (WBE) is a popular tool for the early indication of community spread of infectious diseases. WBE emerged as an effective tool during the COVID-19 pandemic and has provided meaningful information to minimize the spread of ...
Jenna McGowan, Monica Borucki, Hicham Omairi, Merina Varghese, Shahnaz Vellani, Sukanya Chakravarty, Shumin Fan, Srestha Chattopadhyay, Mashuk Siddiquee, James B. Thissen, Nisha Mulakken, Joseph Moon, Jeffrey Kimbrel, Amit K. Tiwari, Roger Travis Taylor, Dae-Wook Kang, Crystal Jaing, Ritu Chakravarti, Saurabh Chattopadhyay   +18 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Garden compost inoculum leads to microbial bioanodes with potential-independent characteristics [PDF]

, 2013
Garden compost leachate was used to form microbial bioanodes under polarization at 0.4, 0.2 and +0.1 V/SCE. Current densities were 6.3 and 8.9 A m2 on average at 0.4 and +0.1 V/SCE respectively, with acetate 10 mM.
Achouak, Wafa, Bertrand, Marie, Pocaznoi, Diana, Byrne, Nathalie, Bergel, Alain, Bertrand-Huleux, Marie, Rimboud, Mickaël, Cercado Quezada, Bibiana   +7 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

First Evaluation Results of the Water Indication Mask as a By-product of the TanDEM-X DEM [PDF]

, 2012
The main goal of the TanDEM-X mission is the production of a global Digital Elevation Model (DEM). A byproduct is the so-called Water Indication Mask (WAM). The purpose of this supplementary information layer is to support the DEM editing process where
Roth, Achim, Gruber, Astrid, Breunig, Markus, Wessel, Birgit, Wendleder, Anna   +4 more
core  

Early-Life β-Lactam Exposure and the Developing Microbiome: Clinical Relevance and Controversies

Microorganisms
Antibiotic-induced dysbiosis has been increasingly implicated in a range of pediatric outcomes, yet the concept remains variably defined and often inconsistently applied. The purpose of this review is to provide an overview and critical evaluation of the
Nilima Rajpal Kundnani, Abhinav Sharma, Mihaela Codrina Levai, Lucretia Marin-Bancila, Doina Georgescu, Loredana Botas, Sorin Dan Chiriac, Mihaela Valcovici, Mihaela-Diana Popa   +8 more
doaj   +1 more source

Gut microbiome profiles may be related to atypical antipsychotic associated overweight in Asian children with psychiatric disorder: a preliminary study

Frontiers in Cellular and Infection Microbiology, 2023
ObjectiveAtypical antipsychotics (APs) modify the gut microbiome, and weight gain in response to AP could be mediated by the gut microbiome. Thus, the present study aimed to explore the changes in the gut bacterial microbiome in AP-exposed children with ...
Shao-rui Hao, Yuan-yue Zhou, Yuan-yue Zhou, Xue Zhang, Xue Zhang, Hai-yin Jiang   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source